Bisphenols exert detrimental effects on neuronal signaling in mature vertebrate brains.

Bisphenols are important plasticizers currently in use and are released at rates of hundreds of tons each year into the biosphere1-3. However, for any bisphenol it is completely unknown if and how it affects the intact adult brain4-6, whose powerful homeostatic mechanisms could potentially compensate any effects bisphenols might have on isolated neurons. Here we analyzed the effects of one month of exposition to BPA or BPS on an identified neuron in the vertebrate brain, using intracellular in vivo recordings in the uniquely suited Mauthner neuron in goldfish. Our findings demonstrate an alarming and uncompensated in vivo impact of both BPA and BPS-at environmentally relevant concentrations-on essential communication functions of neurons in mature vertebrate brains and call for the rapid development of alternative plasticizers. The speed and resolution of the assay we present here could thereby be instrumental to accelerate the early testing phase of next-generation plasticizers.