Yuwei Wang1,2, Qiyu Bo1,2, Huixun Jia1,2, Mengsha Sun1,2, Yang Yu1, Peirong Huang1,2, Jing Wang1,2, Nana Xu1,2, Fenghua Wang3,4,5, Hong Wang6,7,8, Xiaodong Sun1,2,9. 1. Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 2. National Clinical Research Center for Eye Diseases, Shanghai, China. 3. Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. shretina@sjtu.edu.cn. 4. National Clinical Research Center for Eye Diseases, Shanghai, China. shretina@sjtu.edu.cn. 5. Shanghai Key Laboratory of Fundus Diseases, Shanghai, China. shretina@sjtu.edu.cn. 6. Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. wanghong700520@126.com. 7. National Clinical Research Center for Eye Diseases, Shanghai, China. wanghong700520@126.com. 8. Shanghai Key Laboratory of Fundus Diseases, Shanghai, China. wanghong700520@126.com. 9. Shanghai Key Laboratory of Fundus Diseases, Shanghai, China.
Abstract
PURPOSE: To evaluate the diagnostic accuracy of spectral-domain optical coherence tomography (SD-OCT) and swept-source optical coherence tomographic angiography (SS-OCTA) to identify polypoidal lesions in serous or serosanguinous maculopathy. MATERIALS AND METHODS: A retrospective review of patients presenting pigment epithelial detachments (PEDs) with the diagnosis of polypoidal choroidal vasculopathy (PCV), neovascular age-related macular degeneration (nAMD), and central serous chorioretinopathy (CSC), all of which underwent SD-OCT, SS-OCTA, and indocyanine green angiography (ICGA). Typical features of polypoidal lesions on SD-OCT included sharply peaked PED, notched PED, and hyperreflective ring underneath PED. SS-OCTA feature was vascularized PEDs on cross-sectional images corresponding to cluster-like structures on en face images. The parameters of PEDs were measured for analysis. RESULTS: Of 72 eyes, 30 had PCV, 22 had nAMD, and 20 had CSC. A total of 128 localized PEDs were detected on SD-OCT. Typical features on SD-OCT had a high specificity (94.0%) but a limited sensitivity (73.8%). SS-OCTA features provided a higher sensitivity (96.7%). PEDs of the polypoidal lesions unrecognized by SD-OCT were dome-shaped, with smaller ratio of height to base diameter and less area, and almost had heterogeneous internal reflectivity and a connected double-layer sign. Some lesions misidentified by SS-OCTA developed into ICGA-proven polypoidal lesions at follow-up visits. CONCLUSION: A small dome-shaped PED with heterogeneous internal reflectivity and a connected double-layer sign on SD-OCT may suggest a polypoidal lesion of PCV. SS-OCTA may be a helpful tool to investigate preclinical PCV and observe the formation of polypoidal lesions.
PURPOSE: To evaluate the diagnostic accuracy of spectral-domain optical coherence tomography (SD-OCT) and swept-source optical coherence tomographic angiography (SS-OCTA) to identify polypoidal lesions in serous or serosanguinous maculopathy. MATERIALS AND METHODS: A retrospective review of patients presenting pigment epithelial detachments (PEDs) with the diagnosis of polypoidal choroidal vasculopathy (PCV), neovascular age-related macular degeneration (nAMD), and central serous chorioretinopathy (CSC), all of which underwent SD-OCT, SS-OCTA, and indocyanine green angiography (ICGA). Typical features of polypoidal lesions on SD-OCT included sharply peaked PED, notched PED, and hyperreflective ring underneath PED. SS-OCTA feature was vascularized PEDs on cross-sectional images corresponding to cluster-like structures on en face images. The parameters of PEDs were measured for analysis. RESULTS: Of 72 eyes, 30 had PCV, 22 had nAMD, and 20 had CSC. A total of 128 localized PEDs were detected on SD-OCT. Typical features on SD-OCT had a high specificity (94.0%) but a limited sensitivity (73.8%). SS-OCTA features provided a higher sensitivity (96.7%). PEDs of the polypoidal lesions unrecognized by SD-OCT were dome-shaped, with smaller ratio of height to base diameter and less area, and almost had heterogeneous internal reflectivity and a connected double-layer sign. Some lesions misidentified by SS-OCTA developed into ICGA-proven polypoidal lesions at follow-up visits. CONCLUSION: A small dome-shaped PED with heterogeneous internal reflectivity and a connected double-layer sign on SD-OCT may suggest a polypoidal lesion of PCV. SS-OCTA may be a helpful tool to investigate preclinical PCV and observe the formation of polypoidal lesions.
Authors: K Takayama; Y Ito; H Kaneko; K Kataoka; T Sugita; R Maruko; K Hattori; E Ra; F Haga; H Terasaki Journal: Eye (Lond) Date: 2016-11-04 Impact factor: 3.775
Authors: Ian C Holmen; Sri Meghana Konda; Jeong W Pak; Kyle W McDaniel; Barbara Blodi; Kimberly E Stepien; Amitha Domalpally Journal: JAMA Ophthalmol Date: 2020-02-01 Impact factor: 7.389
Authors: Min Wang; Yao Zhou; Simon S Gao; Wei Liu; Yongheng Huang; David Huang; Yali Jia Journal: Invest Ophthalmol Vis Sci Date: 2016-07-01 Impact factor: 4.799