Literature DB >> 17101112

Pigment epithelial detachment in polypoidal choroidal vasculopathy.

Akitaka Tsujikawa1, Manabu Sasahara, Atsushi Otani, Norimoto Gotoh, Takanori Kameda, Daisuke Iwama, Yuko Yodoi, Hiroshi Tamura, Michiko Mandai, Nagahisa Yoshimura.   

Abstract

PURPOSE: To study the morphological features of serosanguineous pigment epithelial detachments (PEDs) with accompanying polypoidal lesions in eyes with polypoidal choroidal vasculopathy (PCV).
DESIGN: Retrospective observational case series.
METHODS: For this observational case study, we retrospectively reviewed 93 consecutive eyes of 85 patients with PCV. The lesions in eyes with PCV were examined with indocyanine green angiography (IA) and optical coherence tomography (OCT).
RESULTS: Of 93 eyes with PCV, 51 eyes (55%) had serous or hemorrhagic PEDs. Of these 51 eyes, a notch in the PED was found in 27 eyes (53%) by angiography, most of which showed polypoidal lesions by IA that corresponded in location to the notch observed by angiography. Polypoidal lesions were detected outside the PED in one eye (2%), at the margin of the PED in 33 eyes (65%), and inside the PED in 12 eyes (24%). OCT revealed that PED had a notch observed tomographically in 29 eyes (57%), most of which corresponded in location to polypoidal lesions seen by IA. In eight eyes, polypoidal lesions, which were adherent to the inner surface of the serous PED, appeared to be detached from the Bruch membrane and the choroid.
CONCLUSIONS: Polypoidal lesions are located at the margin of PED and make a notch in the accompanying PED that is visible by angiography and tomographically. When the polypoidal lesions have increased exudate, the fluid from the lesions infiltrates under the polypoidal lesions themselves, which results in the lesions detaching from the Bruch membrane and appearing to be located inside the PED.

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Year:  2006        PMID: 17101112     DOI: 10.1016/j.ajo.2006.08.025

Source DB:  PubMed          Journal:  Am J Ophthalmol        ISSN: 0002-9394            Impact factor:   5.258


  33 in total

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Authors:  Akitaka Tsujikawa; Sotaro Ooto; Kenji Yamashiro; Hiroshi Tamura; Atsushi Otani; Nagahisa Yoshimura
Journal:  Jpn J Ophthalmol       Date:  2010-08-11       Impact factor: 2.447

2.  Baseline polyp size as a potential predictive factor for recurrence of polypoidal choroidal vasculopathy.

Authors:  Hae Min Kang; Hyoung Jun Koh; Sung Chul Lee
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  2015-12-21       Impact factor: 3.117

3.  [Forms of age-related macular degeneration].

Authors:  M Schargus
Journal:  Ophthalmologe       Date:  2015-04       Impact factor: 1.059

4.  Angiographic features of transgenic mice with increased expression of human serine protease HTRA1 in retinal pigment epithelium.

Authors:  Sandeep Kumar; Zachary Berriochoa; Balamurali K Ambati; Yingbin Fu
Journal:  Invest Ophthalmol Vis Sci       Date:  2014-05-22       Impact factor: 4.799

5.  Pigment epithelial tears after ranibizumab injection in polypoidal choroidal vasculopathy and typical age-related macular degeneration.

Authors:  Joo Youn Shin; Moonjung Choi; Byunghoon Chung; Suk Ho Byeon
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  2015-03-07       Impact factor: 3.117

6.  Detecting abnormalities in choroidal vasculature in a mouse model of age-related macular degeneration by time-course indocyanine green angiography.

Authors:  Sandeep Kumar; Zachary Berriochoa; Alex D Jones; Yingbin Fu
Journal:  J Vis Exp       Date:  2014-02-19       Impact factor: 1.355

7.  [Differential diagnosis and therapy of pigment epithelial detachment].

Authors:  M A Gamulescu; H Helbig; J Wachtlin
Journal:  Ophthalmologe       Date:  2014-01       Impact factor: 1.059

8.  Baseline data from a multicenter, 5-year, prospective cohort study of Japanese age-related macular degeneration: an AMD2000 report.

Authors:  Akitaka Tsujikawa; Yumiko Akagi-Kurashige; Mitsuko Yuzawa; Tatsuro Ishibashi; Hideo Nakanishi; Eiji Nakatani; Satoshi Teramukai; Masanori Fukushima; Nagahisa Yoshimura
Journal:  Jpn J Ophthalmol       Date:  2017-12-21       Impact factor: 2.447

9.  Variability of subfoveal choroidal thickness measurements in patients with age-related macular degeneration and central serous chorioretinopathy.

Authors:  J H Kim; S W Kang; J R Kim; S J Kim
Journal:  Eye (Lond)       Date:  2013-04-19       Impact factor: 3.775

10.  A case of polypoidal choroidal vasculopathy. Periphery is equally important for such patients.

Authors:  Dimitrios A Karagiannis; Vasilios Soublis; Artemios Kandarakis
Journal:  Clin Interv Aging       Date:  2009-06-29       Impact factor: 4.458

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