Literature DB >> 33828259

Towards the understanding of the genetics of somatic mutations.

Xiwei Sun1,2, Jian Yang3,4.   

Abstract

A recent study from Sun et al. reveals a polygenic architecture for pan-cancer tumour mutational burden (TMB) and shows the identification of genes underpinning the associations between germline genetic variants and TMB in specific cancer types. Here we discuss the main findings of the Sun et al. study and the implications for further studies.
© 2021. The Author(s), under exclusive licence to Cancer Research UK.

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Year:  2021        PMID： 33828259      PMCID： PMC8405720          DOI： 10.1038/s41416-021-01369-y

Source DB:  PubMed          Journal:  Br J Cancer        ISSN： 0007-0920            Impact factor:   7.640


  11 in total

1.  Nivolumab plus Ipilimumab in Lung Cancer with a High Tumor Mutational Burden.

Authors:  Matthew D Hellmann; Tudor-Eliade Ciuleanu; Adam Pluzanski; Jong Seok Lee; Gregory A Otterson; Clarisse Audigier-Valette; Elisa Minenza; Helena Linardou; Sjaak Burgers; Pamela Salman; Hossein Borghaei; Suresh S Ramalingam; Julie Brahmer; Martin Reck; Kenneth J O'Byrne; William J Geese; George Green; Han Chang; Joseph Szustakowski; Prabhu Bhagavatheeswaran; Diane Healey; Yali Fu; Faith Nathan; Luis Paz-Ares
Journal:  N Engl J Med       Date:  2018-04-16       Impact factor: 91.245

2.  Genomic landscape of lung adenocarcinoma in East Asians.

Authors:  Jianbin Chen; Hechuan Yang; Audrey Su Min Teo; Lidyana Bte Amer; Faranak Ghazi Sherbaf; Chu Quan Tan; Jacob Josiah Santiago Alvarez; Bingxin Lu; Jia Qi Lim; Angela Takano; Rahul Nahar; Yin Yeng Lee; Cheryl Zi Jin Phua; Khi Pin Chua; Lisda Suteja; Pauline Jieqi Chen; Mei Mei Chang; Tina Puay Theng Koh; Boon-Hean Ong; Devanand Anantham; Anne Ann Ling Hsu; Apoorva Gogna; Chow Wei Too; Zaw Win Aung; Yi Fei Lee; Lanying Wang; Tony Kiat Hon Lim; Andreas Wilm; Poh Sum Choi; Poh Yong Ng; Chee Keong Toh; Wan-Teck Lim; Siming Ma; Bing Lim; Jin Liu; Wai Leong Tam; Anders Jacobsen Skanderup; Joe Poh Sheng Yeong; Eng-Huat Tan; Caretha L Creasy; Daniel Shao Weng Tan; Axel M Hillmer; Weiwei Zhai
Journal:  Nat Genet       Date:  2020-02-03       Impact factor: 38.330

3.  Signatures of negative selection in the genetic architecture of human complex traits.

Authors:  Jian Zeng; Ronald de Vlaming; Yang Wu; Matthew R Robinson; Luke R Lloyd-Jones; Loic Yengo; Chloe X Yap; Angli Xue; Julia Sidorenko; Allan F McRae; Joseph E Powell; Grant W Montgomery; Andres Metspalu; Tonu Esko; Greg Gibson; Naomi R Wray; Peter M Visscher; Jian Yang
Journal:  Nat Genet       Date:  2018-04-16       Impact factor: 38.330

4.  Tumor mutational load predicts survival after immunotherapy across multiple cancer types.

Authors:  Robert M Samstein; Chung-Han Lee; Alexander N Shoushtari; Matthew D Hellmann; Ronglai Shen; Yelena Y Janjigian; David A Barron; Ahmet Zehir; Emmet J Jordan; Antonio Omuro; Thomas J Kaley; Sviatoslav M Kendall; Robert J Motzer; A Ari Hakimi; Martin H Voss; Paul Russo; Jonathan Rosenberg; Gopa Iyer; Bernard H Bochner; Dean F Bajorin; Hikmat A Al-Ahmadie; Jamie E Chaft; Charles M Rudin; Gregory J Riely; Shrujal Baxi; Alan L Ho; Richard J Wong; David G Pfister; Jedd D Wolchok; Christopher A Barker; Philip H Gutin; Cameron W Brennan; Viviane Tabar; Ingo K Mellinghoff; Lisa M DeAngelis; Charlotte E Ariyan; Nancy Lee; William D Tap; Mrinal M Gounder; Sandra P D'Angelo; Leonard Saltz; Zsofia K Stadler; Howard I Scher; Jose Baselga; Pedram Razavi; Christopher A Klebanoff; Rona Yaeger; Neil H Segal; Geoffrey Y Ku; Ronald P DeMatteo; Marc Ladanyi; Naiyer A Rizvi; Michael F Berger; Nadeem Riaz; David B Solit; Timothy A Chan; Luc G T Morris
Journal:  Nat Genet       Date:  2019-01-14       Impact factor: 38.330

5.  Blood-based tumor mutational burden as a predictor of clinical benefit in non-small-cell lung cancer patients treated with atezolizumab.

Authors:  David R Gandara; Sarah M Paul; Marcin Kowanetz; Erica Schleifman; Wei Zou; Yan Li; Achim Rittmeyer; Louis Fehrenbacher; Geoff Otto; Christine Malboeuf; Daniel S Lieber; Doron Lipson; Jacob Silterra; Lukas Amler; Todd Riehl; Craig A Cummings; Priti S Hegde; Alan Sandler; Marcus Ballinger; David Fabrizio; Tony Mok; David S Shames
Journal:  Nat Med       Date:  2018-08-06       Impact factor: 53.440

6.  Mutational signatures associated with tobacco smoking in human cancer.

Authors:  Ludmil B Alexandrov; Young Seok Ju; Kerstin Haase; Peter Van Loo; Iñigo Martincorena; Serena Nik-Zainal; Yasushi Totoki; Akihiro Fujimoto; Hidewaki Nakagawa; Tatsuhiro Shibata; Peter J Campbell; Paolo Vineis; David H Phillips; Michael R Stratton
Journal:  Science       Date:  2016-11-04       Impact factor: 47.728

7.  Tumor Mutational Burden Is Polygenic and Genetically Associated with Complex Traits and Diseases.

Authors:  Xiwei Sun; Angli Xue; Ting Qi; Dan Chen; Dandan Shi; Yang Wu; Zhili Zheng; Jian Zeng; Jian Yang
Journal:  Cancer Res       Date:  2021-01-08       Impact factor: 12.701

8.  Genetic Ancestry Contributes to Somatic Mutations in Lung Cancers from Admixed Latin American Populations.

Authors:  Jian Carrot-Zhang; Giovanny Soca-Chafre; Nick Patterson; Aaron R Thorner; Anwesha Nag; Jacqueline Watson; Giulio Genovese; July Rodriguez; Maya K Gelbard; Luis Corrales-Rodriguez; Yoichiro Mitsuishi; Gavin Ha; Joshua D Campbell; Geoffrey R Oxnard; Oscar Arrieta; Andres F Cardona; Alexander Gusev; Matthew Meyerson
Journal:  Cancer Discov       Date:  2020-12-02       Impact factor: 38.272

9.  A Compendium of Mutational Signatures of Environmental Agents.

Authors:  Jill E Kucab; Xueqing Zou; Sandro Morganella; Madeleine Joel; A Scott Nanda; Eszter Nagy; Celine Gomez; Andrea Degasperi; Rebecca Harris; Stephen P Jackson; Volker M Arlt; David H Phillips; Serena Nik-Zainal
Journal:  Cell       Date:  2019-04-11       Impact factor: 41.582

10.  A role for kinesin-1 subunits KIF5B/KLC1 in regulating epithelial mesenchymal plasticity in breast tumorigenesis.

Authors:  Alaa Moamer; Ibrahim Y Hachim; Najat Binothman; Ni Wang; Jean-Jacques Lebrun; Suhad Ali
Journal:  EBioMedicine       Date:  2019-06-14       Impact factor: 8.143
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