| Literature DB >> 32015526 |
Jianbin Chen1, Hechuan Yang1,2, Audrey Su Min Teo1, Lidyana Bte Amer1, Faranak Ghazi Sherbaf1, Chu Quan Tan1, Jacob Josiah Santiago Alvarez1, Bingxin Lu1, Jia Qi Lim1, Angela Takano3, Rahul Nahar1, Yin Yeng Lee1, Cheryl Zi Jin Phua1, Khi Pin Chua1, Lisda Suteja4, Pauline Jieqi Chen1, Mei Mei Chang1, Tina Puay Theng Koh5, Boon-Hean Ong6, Devanand Anantham7, Anne Ann Ling Hsu7, Apoorva Gogna8, Chow Wei Too8, Zaw Win Aung9, Yi Fei Lee1,10, Lanying Wang9, Tony Kiat Hon Lim3, Andreas Wilm1, Poh Sum Choi1, Poh Yong Ng1, Chee Keong Toh4, Wan-Teck Lim4,11, Siming Ma1, Bing Lim1, Jin Liu12, Wai Leong Tam1,10,13,14, Anders Jacobsen Skanderup1, Joe Poh Sheng Yeong3,11, Eng-Huat Tan4,9, Caretha L Creasy15, Daniel Shao Weng Tan16,17,18, Axel M Hillmer19,20, Weiwei Zhai21,22,23,24.
Abstract
Lung cancer is the world's leading cause of cancer death and shows strong ancestry disparities. By sequencing and assembling a large genomic and transcriptomic dataset of lung adenocarcinoma (LUAD) in individuals of East Asian ancestry (EAS; n = 305), we found that East Asian LUADs had more stable genomes characterized by fewer mutations and fewer copy number alterations than LUADs from individuals of European ancestry. This difference is much stronger in smokers as compared to nonsmokers. Transcriptomic clustering identified a new EAS-specific LUAD subgroup with a less complex genomic profile and upregulated immune-related genes, allowing the possibility of immunotherapy-based approaches. Integrative analysis across clinical and molecular features showed the importance of molecular phenotypes in patient prognostic stratification. EAS LUADs had better prediction accuracy than those of European ancestry, potentially due to their less complex genomic architecture. This study elucidated a comprehensive genomic landscape of EAS LUADs and highlighted important ancestry differences between the two cohorts.Entities:
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Year: 2020 PMID： 32015526 DOI： 10.1038/s41588-019-0569-6
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330