| Literature DB >> 33268447 |
Jian Carrot-Zhang1,2,3, Giovanny Soca-Chafre4, Nick Patterson2,3, Aaron R Thorner1, Anwesha Nag1, Jacqueline Watson1,2, Giulio Genovese2,3, July Rodriguez5, Maya K Gelbard1, Luis Corrales-Rodriguez6,7, Yoichiro Mitsuishi8, Gavin Ha9, Joshua D Campbell10, Geoffrey R Oxnard1, Oscar Arrieta11,12, Andres F Cardona13,14, Alexander Gusev15,2,16, Matthew Meyerson15,2,3.
Abstract
Inherited lung cancer risk, particularly in nonsmokers, is poorly understood. Genomic and ancestry analysis of 1,153 lung cancers from Latin America revealed striking associations between Native American ancestry and their somatic landscape, including tumor mutational burden, and specific driver mutations in EGFR, KRAS, and STK11. A local Native American ancestry risk score was more strongly correlated with EGFR mutation frequency compared with global ancestry correlation, suggesting that germline genetics (rather than environmental exposure) underlie these disparities. SIGNIFICANCE: The frequency of somatic EGFR and KRAS mutations in lung cancer varies by ethnicity, but we do not understand why. Our study suggests that the variation in EGFR and KRAS mutation frequency is associated with genetic ancestry and suggests further studies to identify germline alleles that underpin this association.See related commentary by Gomez et al., p. 534.This article is highlighted in the In This Issue feature, p. 521. ©2020 American Association for Cancer Research.Entities:
Mesh：
Substances：
Year: 2020 PMID： 33268447 PMCID： PMC7933062 DOI： 10.1158/2159-8290.CD-20-1165
Source DB: PubMed Journal: Cancer Discov ISSN： 2159-8274 Impact factor: 38.272