| Literature DB >> 33824913 |
Ambroise Ahouidi1, Mozam Ali2, Jacob Almagro-Garcia2,3, Alfred Amambua-Ngwa2,4, Chanaki Amaratunga5, Roberto Amato2,3, Lucas Amenga-Etego6,7, Ben Andagalu8, Tim J C Anderson9, Voahangy Andrianaranjaka10, Tobias Apinjoh11, Cristina Ariani2, Elizabeth A Ashley12, Sarah Auburn13,14, Gordon A Awandare7,15, Hampate Ba16, Vito Baraka17,18, Alyssa E Barry19,20,21, Philip Bejon22, Gwladys I Bertin23, Maciej F Boni14,24, Steffen Borrmann25, Teun Bousema26,27, Oralee Branch28, Peter C Bull22,29, George B J Busby3, Thanat Chookajorn30, Kesinee Chotivanich30, Antoine Claessens4,31, David Conway26, Alister Craig32,33, Umberto D'Alessandro4, Souleymane Dama34, Nicholas Pj Day12, Brigitte Denis33, Mahamadou Diakite34, Abdoulaye Djimdé34, Christiane Dolecek14, Arjen M Dondorp12, Chris Drakeley26, Eleanor Drury2, Patrick Duffy5, Diego F Echeverry35,36, Thomas G Egwang37, Berhanu Erko38, Rick M Fairhurst39, Abdul Faiz40, Caterina A Fanello12, Mark M Fukuda41, Dionicia Gamboa42, Anita Ghansah43, Lemu Golassa38, Sonia Goncalves2, William L Hamilton2,44, G L Abby Harrison21, Lee Hart3, Christa Henrichs3, Tran Tinh Hien24,45, Catherine A Hill46, Abraham Hodgson47, Christina Hubbart48, Mallika Imwong30, Deus S Ishengoma17,49, Scott A Jackson50, Chris G Jacob2, Ben Jeffery3, Anna E Jeffreys48, Kimberly J Johnson3, Dushyanth Jyothi2, Claire Kamaliddin23, Edwin Kamau51, Mihir Kekre2, Krzysztof Kluczynski3, Theerarat Kochakarn2,30, Abibatou Konaté52, Dominic P Kwiatkowski2,3,48, Myat Phone Kyaw53,54, Pharath Lim5,55, Chanthap Lon41, Kovana M Loua56, Oumou Maïga-Ascofaré34,57,58, Cinzia Malangone2, Magnus Manske2, Jutta Marfurt13, Kevin Marsh14,59, Mayfong Mayxay60,61, Alistair Miles2,3, Olivo Miotto2,3,12, Victor Mobegi62, Olugbenga A Mokuolu63, Jacqui Montgomery64, Ivo Mueller21,65, Paul N Newton66, Thuy Nguyen2, Thuy-Nhien Nguyen24, Harald Noedl67, Francois Nosten14,68, Rintis Noviyanti69, Alexis Nzila70, Lynette I Ochola-Oyier22, Harold Ocholla71,72, Abraham Oduro6, Irene Omedo22, Marie A Onyamboko73, Jean-Bosco Ouedraogo74, Kolapo Oyebola75,76, Richard D Pearson2,3, Norbert Peshu22, Aung Pyae Phyo12,68, Chris V Plowe77, Ric N Price12,13,45, Sasithon Pukrittayakamee30, Milijaona Randrianarivelojosia78,79, Julian C Rayner2, Pascal Ringwald80, Kirk A Rockett2,48, Katherine Rowlands48, Lastenia Ruiz81, David Saunders41, Alex Shayo82, Peter Siba83, Victoria J Simpson3, Jim Stalker2, Xin-Zhuan Su5, Colin Sutherland26, Shannon Takala-Harrison84, Livingstone Tavul83, Vandana Thathy22,85, Antoinette Tshefu86, Federica Verra87, Joseph Vinetz42,88, Thomas E Wellems5, Jason Wendler48, Nicholas J White12, Ian Wright3, William Yavo52,89, Htut Ye90.
Abstract
MalariaGEN is a data-sharing network that enables groups around the world to work together on the genomic epidemiology of malaria. Here we describe a new release of curated genome variation data on 7,000 Plasmodium falciparum samples from MalariaGEN partner studies in 28 malaria-endemic countries. High-quality genotype calls on 3 million single nucleotide polymorphisms (SNPs) and short indels were produced using a standardised analysis pipeline. Copy number variants associated with drug resistance and structural variants that cause failure of rapid diagnostic tests were also analysed. Almost all samples showed genetic evidence of resistance to at least one antimalarial drug, and some samples from Southeast Asia carried markers of resistance to six commonly-used drugs. Genes expressed during the mosquito stage of the parasite life-cycle are prominent among loci that show strong geographic differentiation. By continuing to enlarge this open data resource we aim to facilitate research into the evolutionary processes affecting malaria control and to accelerate development of the surveillance toolkit required for malaria elimination. Copyright:Entities:
Keywords: data resource; drug resistance; evolution; genomic epidemiology; genomics; malaria; plasmodium falciparum; population genetics; rapid diagnostic test failure
Year: 2021 PMID： 33824913 PMCID： PMC8008441.2 DOI： 10.12688/wellcomeopenres.16168.2
Source DB: PubMed Journal: Wellcome Open Res ISSN： 2398-502X