Literature DB >> 33821788

Likelihood approximation networks (LANs) for fast inference of simulation models in cognitive neuroscience.

Alexander Fengler1,2, Lakshmi N Govindarajan1,2, Tony Chen3, Michael J Frank1,2.   

Abstract

In cognitive neuroscience, computational modeling can formally adjudicate between theories and affords quantitative fits to behavioral/brain data. Pragmatically, however, the space of plausible generative models considered is dramatically limited by the set of models with known likelihood functions. For many models, the lack of a closed-form likelihood typically impedes Bayesian inference methods. As a result, standard models are evaluated for convenience, even when other models might be superior. Likelihood-free methods exist but are limited by their computational cost or their restriction to particular inference scenarios. Here, we propose neural networks that learn approximate likelihoods for arbitrary generative models, allowing fast posterior sampling with only a one-off cost for model simulations that is amortized for future inference. We show that these methods can accurately recover posterior parameter distributions for a variety of neurocognitive process models. We provide code allowing users to deploy these methods for arbitrary hierarchical model instantiations without further training.
© 2021, Fengler et al.

Entities:  

Keywords:  approximate bayesian computation; cognitive neuroscience; computational models; human; mouse; neural networks; neuroscience; rat; rhesus macaque; sequential sampling models

Mesh:

Year:  2021        PMID: 33821788      PMCID: PMC8102064          DOI: 10.7554/eLife.65074

Source DB:  PubMed          Journal:  Elife        ISSN: 2050-084X            Impact factor:   8.140


  46 in total

1.  Subthalamic nucleus stimulation reverses mediofrontal influence over decision threshold.

Authors:  James F Cavanagh; Thomas V Wiecki; Michael X Cohen; Christina M Figueroa; Johan Samanta; Scott J Sherman; Michael J Frank
Journal:  Nat Neurosci       Date:  2011-09-25       Impact factor: 24.884

2.  Towards end-to-end likelihood-free inference with convolutional neural networks.

Authors:  Stefan T Radev; Ulf K Mertens; Andreas Voss; Ullrich Köthe
Journal:  Br J Math Stat Psychol       Date:  2019-02-22       Impact factor: 3.380

3.  Cortico-striatal connections predict control over speed and accuracy in perceptual decision making.

Authors:  Birte U Forstmann; Alfred Anwander; Andreas Schäfer; Jane Neumann; Scott Brown; Eric-Jan Wagenmakers; Rafal Bogacz; Robert Turner
Journal:  Proc Natl Acad Sci U S A       Date:  2010-08-23       Impact factor: 11.205

4.  Individual Differences and Fitting Methods for the Two-Choice Diffusion Model of Decision Making.

Authors:  Roger Ratcliff; Russ Childers
Journal:  Decision (Wash D C )       Date:  2015

5.  Revealing Neurocomputational Mechanisms of Reinforcement Learning and Decision-Making With the hBayesDM Package.

Authors:  Woo-Young Ahn; Nathaniel Haines; Lei Zhang
Journal:  Comput Psychiatr       Date:  2017-10-01

6.  A causal role for right frontopolar cortex in directed, but not random, exploration.

Authors:  Wojciech K Zajkowski; Malgorzata Kossut; Robert C Wilson
Journal:  Elife       Date:  2017-09-15       Impact factor: 8.140

7.  HDDM: Hierarchical Bayesian estimation of the Drift-Diffusion Model in Python.

Authors:  Thomas V Wiecki; Imri Sofer; Michael J Frank
Journal:  Front Neuroinform       Date:  2013-08-02       Impact factor: 4.081

8.  Causal contribution and dynamical encoding in the striatum during evidence accumulation.

Authors:  Michael M Yartsev; Timothy D Hanks; Alice Misun Yoon; Carlos D Brody
Journal:  Elife       Date:  2018-08-24       Impact factor: 8.140

9.  Prepaid parameter estimation without likelihoods.

Authors:  Merijn Mestdagh; Stijn Verdonck; Kristof Meers; Tim Loossens; Francis Tuerlinckx
Journal:  PLoS Comput Biol       Date:  2019-09-09       Impact factor: 4.475

Review 10.  SciPy 1.0: fundamental algorithms for scientific computing in Python.

Authors:  Pauli Virtanen; Ralf Gommers; Travis E Oliphant; Matt Haberland; Tyler Reddy; David Cournapeau; Evgeni Burovski; Pearu Peterson; Warren Weckesser; Jonathan Bright; Stéfan J van der Walt; Matthew Brett; Joshua Wilson; K Jarrod Millman; Nikolay Mayorov; Andrew R J Nelson; Eric Jones; Robert Kern; Eric Larson; C J Carey; İlhan Polat; Yu Feng; Eric W Moore; Jake VanderPlas; Denis Laxalde; Josef Perktold; Robert Cimrman; Ian Henriksen; E A Quintero; Charles R Harris; Anne M Archibald; Antônio H Ribeiro; Fabian Pedregosa; Paul van Mulbregt
Journal:  Nat Methods       Date:  2020-02-03       Impact factor: 28.547

View more
  3 in total

Review 1.  Advances in modeling learning and decision-making in neuroscience.

Authors:  Anne G E Collins; Amitai Shenhav
Journal:  Neuropsychopharmacology       Date:  2021-08-27       Impact factor: 7.853

2.  Flexible and efficient simulation-based inference for models of decision-making.

Authors:  Jan Boelts; Jan-Matthis Lueckmann; Richard Gao; Jakob H Macke
Journal:  Elife       Date:  2022-07-27       Impact factor: 8.713

3.  Persistent activity in human parietal cortex mediates perceptual choice repetition bias.

Authors:  Anne E Urai; Tobias H Donner
Journal:  Nat Commun       Date:  2022-10-12       Impact factor: 17.694

  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.