Marwa Hajji1,2, Rania Khedher1,3, Mehdi Mrad1,4, Hammami Mohamed Bassem1,2, Nawel Rafrafi5, Salma Chouchi6, Moncef Feki1,2, Afef Bahlous1,4, Karim Zouaghi1,3, Hayet Fellah1,2. 1. University of Tunis El Manar, Faculty of Medicine of Tunis, Tunis, Tunisia. 2. Rabta University Hospital, Laboratory of Biochemistry, Tunis, Tunisia. 3. Rabta University Hospital, Department of Nephrology, Tunis, Tunisia. 4. Pasteur Institute, Laboratory of Biochemistry, Tunis, Tunisia. 5. Radial Hemodialysis Clinic, Manouba, Tunisia. 6. Udial Hemodialysis Clinic, Tunis, Tunisia.
Abstract
BACKGROUND: Zinc (Zn) deficiency is a common condition and could contribute to poor outcomes in hemodialysis (HD) patients. The aim of this study was to evaluate the effects of Zn supplementation on serum copper (Cu) to Zn and C-reactive protein (CRP) to albumin ratios (CAR) in HD patients. METHODS: Seventy-seven HD patients were enrolled in a multicentre simple-blind randomized clinical trial. Only 37 HD patients completed the study; they were randomly divided into two groups and supplemented with zinc sulphate (n=17) or placebo (n=20) for two months. Serum Zn and Cu were measured by atomic absorption spectrophotometry. Serum albumin and hypersensitive-CRP were assessed by colorimetric and immunoturbidimetric method, respectively. Determinations were performed before and after supplementation. RESULTS: After two months of supplementation, serum Zn significantly increased, and Cu to Zn ratio decreased in Zn supplemented group, but remained unchanged in the placebo group. In parallel, serum albumin concentrations significantly increased, and CAR decreased in Zn supplemented group only. CONCLUSIONS: Zn supplementation reduces Cu to Zn and CRP to albumin ratios in HD patients. These changes point towards an improvement in nutritional, oxidative and inflammatory status. The study findings suggest that correcting Zn deficiency reduces poor outcomes in HD patients. 2021 Marwa Hajji, Rania Khedher, Mehdi Mrad, Hammami Mohamed Bassem, Nawel Rafrafi, Salma Chouchi, Moncef Feki, Afef Bahlous, Karim Zouaghi, Hayet Fellah, published by CEON/CEES.
BACKGROUND: Zinc (Zn) deficiency is a common condition and could contribute to poor outcomes in hemodialysis (HD) patients. The aim of this study was to evaluate the effects of Zn supplementation on serum copper (Cu) to Zn and C-reactive protein (CRP) to albumin ratios (CAR) in HD patients. METHODS: Seventy-seven HD patients were enrolled in a multicentre simple-blind randomized clinical trial. Only 37 HD patients completed the study; they were randomly divided into two groups and supplemented with zinc sulphate (n=17) or placebo (n=20) for two months. Serum Zn and Cu were measured by atomic absorption spectrophotometry. Serum albumin and hypersensitive-CRP were assessed by colorimetric and immunoturbidimetric method, respectively. Determinations were performed before and after supplementation. RESULTS: After two months of supplementation, serum Zn significantly increased, and Cu to Zn ratio decreased in Zn supplemented group, but remained unchanged in the placebo group. In parallel, serum albumin concentrations significantly increased, and CAR decreased in Zn supplemented group only. CONCLUSIONS: Zn supplementation reduces Cu to Zn and CRP to albumin ratios in HD patients. These changes point towards an improvement in nutritional, oxidative and inflammatory status. The study findings suggest that correcting Zn deficiency reduces poor outcomes in HD patients. 2021 Marwa Hajji, Rania Khedher, Mehdi Mrad, Hammami Mohamed Bassem, Nawel Rafrafi, Salma Chouchi, Moncef Feki, Afef Bahlous, Karim Zouaghi, Hayet Fellah, published by CEON/CEES.
Entities:
Keywords:
C-reactive protein to albumin ratio; copper to zinc ratio; hemodialysis; zinc supplement
Authors: Frank Fung; Donald J Sherrard; Daniel L Gillen; Craig Wong; Bryan Kestenbaum; Steven Seliger; Adrianne Ball; Catherine Stehman-Breen Journal: Am J Kidney Dis Date: 2002-08 Impact factor: 8.860
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