OBJECTIVE: We examined the effects of zinc supplementation on serum zinc and C-reactive protein concentrations in hemodialysis patients. DESIGN: This was a randomized, double-blinded, placebo-controlled clinical trial. SETTING: This study was conducted at the Shahid Faghihi and Namazi Dialysis Centers in Shiraz, Iran. PATIENTS: Fifty-five hemodialysis patients (32 men and 23 women) participated after meeting the following criteria: zinc deficiency, treated for a minimum of 6 months; no record of hospitalizations in the preceding 3 months; and hemodialysis treatment 2 to 3 times per week. INTERVENTION: Patients were randomly divided into two groups. The zinc supplementation group (n=28) received a 220-mg zinc sulfate capsule, and the control group (n=27) received a placebo capsule (220 mg corn starch), for 42 days. MAIN OUTCOME MEASURES: Fasting, predialysis serum samples were collected on days 0 and 42 to determine serum zinc and C-reactive protein levels. RESULTS: After supplementation, subjects in the zinc-supplemented group showed significant increases in serum zinc concentrations, from 57.4+/-2.4 microg/dL SEM on day 0 to 88.4+/-4.8 microg/dL SEM on day 42. Serum C-reactive protein concentrations were initially high among subjects in the control (15.1+/-3.9 mg/L SEM) and zinc-supplemented (13.5+/-3.8 mg/L SEM) groups. Serum C-reactive protein concentrations in the control group increased throughout the study period, but did not reach statistical significance. A progressive decrease in serum C-reactive protein concentrations was observed in the zinc-supplemented group from the beginning (13.5+/-3.8mg/L SEM) to the end (10.5+/-3.5mg/L SEM) of the study, but this event was not significant. CONCLUSION:Zinc supplementation intake may cause an increase in serum zinc concentrations, leading to a decrease of inflammation in hemodialysis patients.
RCT Entities:
OBJECTIVE: We examined the effects of zinc supplementation on serum zinc and C-reactive protein concentrations in hemodialysis patients. DESIGN: This was a randomized, double-blinded, placebo-controlled clinical trial. SETTING: This study was conducted at the Shahid Faghihi and Namazi Dialysis Centers in Shiraz, Iran. PATIENTS: Fifty-five hemodialysis patients (32 men and 23 women) participated after meeting the following criteria: zinc deficiency, treated for a minimum of 6 months; no record of hospitalizations in the preceding 3 months; and hemodialysis treatment 2 to 3 times per week. INTERVENTION: Patients were randomly divided into two groups. The zinc supplementation group (n=28) received a 220-mg zinc sulfate capsule, and the control group (n=27) received a placebo capsule (220 mg corn starch), for 42 days. MAIN OUTCOME MEASURES: Fasting, predialysis serum samples were collected on days 0 and 42 to determine serum zinc and C-reactive protein levels. RESULTS: After supplementation, subjects in the zinc-supplemented group showed significant increases in serum zinc concentrations, from 57.4+/-2.4 microg/dL SEM on day 0 to 88.4+/-4.8 microg/dL SEM on day 42. Serum C-reactive protein concentrations were initially high among subjects in the control (15.1+/-3.9 mg/L SEM) and zinc-supplemented (13.5+/-3.8 mg/L SEM) groups. Serum C-reactive protein concentrations in the control group increased throughout the study period, but did not reach statistical significance. A progressive decrease in serum C-reactive protein concentrations was observed in the zinc-supplemented group from the beginning (13.5+/-3.8mg/L SEM) to the end (10.5+/-3.5mg/L SEM) of the study, but this event was not significant. CONCLUSION: Zinc supplementation intake may cause an increase in serum zinc concentrations, leading to a decrease of inflammation in hemodialysis patients.
Authors: Jakob Voelkl; Rashad Tuffaha; Trang T D Luong; Daniel Zickler; Jaber Masyout; Martina Feger; Nicolas Verheyen; Florian Blaschke; Makoto Kuro-O; Andreas Tomaschitz; Stefan Pilz; Andreas Pasch; Kai-Uwe Eckardt; Juergen E Scherberich; Florian Lang; Burkert Pieske; Ioana Alesutan Journal: J Am Soc Nephrol Date: 2018-04-13 Impact factor: 10.121
Authors: Razieh Hosseini; Farzaneh Montazerifar; Elham Shahraki; Mansour Karajibani; Ali Mohammad Mokhtari; Ali Reza Dashipour; Gordon A Ferns; Mohammad Jalali Journal: Biol Trace Elem Res Date: 2021-03-03 Impact factor: 3.738
Authors: Marcello Tonelli; Natasha Wiebe; Stephanie Thompson; David Kinniburgh; Scott W Klarenbach; Michael Walsh; Aminu K Bello; Labib Faruque; Catherine Field; Braden J Manns; Brenda R Hemmelgarn Journal: BMC Nephrol Date: 2015-04-11 Impact factor: 2.388