Haci Hasan Ozkan1, Mustafa Koc2, Hasan Kiziltoprak3, Kemal Tekin4, Emre Aydemir5. 1. Ophthalmology Department, Ankara Occupational and Environmental Diseases Hospital, Ankara, Turkey. drhacihasanozkan@gmail.com. 2. Ophthalmology Department, Kayseri Mayagoz Hospital, Kayseri, Turkey. 3. Ophthalmology Department, Adiyaman University Faculty of Medicine, Adiyaman, Turkey. 4. Ophthalmology Department, Hatay Mustafa Kemal University Faculty of Medicine, Hatay, Turkey. 5. Ophthalmology Department, Adıyaman Training and Research Hospital, Adıyaman, Turkey.
Abstract
PURPOSE: To investigate topographic, tomographic, topometric, densitometric, and aberrometric parameters in subclinical keratoconus with the Pentacam HR imaging system. METHODS: Data of 3128 patients were evaluated, finding in 108 patients clinical keratoconus in one eye and subclinical keratoconus in the other. Corneal topographic, tomographic, topometric, densitometric, and aberrometric values obtained using the Pentacam HR imaging system were compared between clinical keratoconus, subclinical keratoconus, and normal eyes. RESULTS: Comparing eyes with subclinical keratoconus and the control group, while flat K, horizontal coma, horizontal trefoil, and vertical trefoil values were similar (p > 0.05 for each), all other parameters were significantly different (p < 0.05 for each). Densitometry values of eyes with subclinical keratoconus were significantly higher in all layers of the 0-2 mm annular area and in the anterior and central layers of the 2-6 mm annular area compared to the control group (p < 0.05 for each). According to the receiver operating characteristic curve analysis, the densitometry region with the largest area under the curve was the anterior layer of the 0-2 mm annular area. The sensitivity in this region was 79.4% and the specificity 73.2% in distinguishing eyes with subclinical keratoconus from normal eyes when 19.3 GSU was considered the threshold. CONCLUSION: Corneal densitometry values in the 0-2 and 2-6 mm annular areas, especially in the anterior layers, are parameters that can be used to predict and distinguish subclinical keratoconus from normal eyes.
PURPOSE: To investigate topographic, tomographic, topometric, densitometric, and aberrometric parameters in subclinical keratoconus with the Pentacam HR imaging system. METHODS: Data of 3128 patients were evaluated, finding in 108 patients clinical keratoconus in one eye and subclinical keratoconus in the other. Corneal topographic, tomographic, topometric, densitometric, and aberrometric values obtained using the Pentacam HR imaging system were compared between clinical keratoconus, subclinical keratoconus, and normal eyes. RESULTS: Comparing eyes with subclinical keratoconus and the control group, while flat K, horizontal coma, horizontal trefoil, and vertical trefoil values were similar (p > 0.05 for each), all other parameters were significantly different (p < 0.05 for each). Densitometry values of eyes with subclinical keratoconus were significantly higher in all layers of the 0-2 mm annular area and in the anterior and central layers of the 2-6 mm annular area compared to the control group (p < 0.05 for each). According to the receiver operating characteristic curve analysis, the densitometry region with the largest area under the curve was the anterior layer of the 0-2 mm annular area. The sensitivity in this region was 79.4% and the specificity 73.2% in distinguishing eyes with subclinical keratoconus from normal eyes when 19.3 GSU was considered the threshold. CONCLUSION: Corneal densitometry values in the 0-2 and 2-6 mm annular areas, especially in the anterior layers, are parameters that can be used to predict and distinguish subclinical keratoconus from normal eyes.
Authors: Keith M Meek; Stephen J Tuft; Yifei Huang; Paulvinder S Gill; Sally Hayes; Richard H Newton; Anthony J Bron Journal: Invest Ophthalmol Vis Sci Date: 2005-06 Impact factor: 4.799
Authors: Rafael Vidal Merola; Sebastião Cronemberger; Artur William Veloso; Alberto Diniz-Filho Journal: Int J Ophthalmol Date: 2022-01-18 Impact factor: 1.779