Marie S Sandvei1,2, Signe Opdahl1, Marit Valla3,4, Pagona Lagiou5,6, Ellen Veronika Vesterfjell4, Tor Vikan Rise3,4, Tina Syvertsen Overrein4, Anette H Skjervold3, Monica J Engstrøm3,7, Anna M Bofin3, Lars J Vatten8. 1. Faculty of Medicine and Health Sciences, Department of Public Health and Nursing, Norwegian University of Science and Technology, Post box 8905, N-7491, Trondheim, Norway. 2. The Cancer Clinic, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway. 3. NTNU, Faculty of Medicine and Health Sciences, Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Post box 8905, N-7491, Trondheim, Norway. 4. Department of Pathology, St. Olavs Hospital HF, Trondheim University Hospital, Postboks 3250 Torgarden, 7006, Trondheim, Norway. 5. Department of Hygiene, Epidemiology and Medical Statistics, School of Medicine, National and Kapodistrian University of Athens, 75 M. Asias Street, Goudi, GR-115 27, Athens, Greece. 6. Department of Epidemiology, Harvard School of Public Health, Boston, USA. 7. Department of Breast and Endocrine Surgery, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway. 8. Faculty of Medicine and Health Sciences, Department of Public Health and Nursing, Norwegian University of Science and Technology, Post box 8905, N-7491, Trondheim, Norway. lars.vatten@ntnu.no.
Abstract
BACKGROUND: Because birth size appears to be positively associated with breast cancer risk, we have studied whether this risk may differ according to molecular breast cancer subtypes. METHODS: A cohort of 22,931 women born 1920-1966 were followed up for breast cancer occurrence from 1961 to 2012, and 870 were diagnosed during follow-up. Archival diagnostic material from 537 patients was available to determine molecular breast cancer subtype, specified as Luminal A, Luminal B (human epidermal growth factor receptor 2 (HER2)-), Luminal B (HER2+), HER2 type, and Triple negative (TN) breast cancer. Information on the women's birth weight, birth length and head circumference at birth was used to estimate hazard ratios (HR) with 95% confidence intervals (CI) for each molecular subtype, applying Cox regression, and stratified by maternal height. RESULTS: Birth length (per 2 cm increments) was positively associated with Luminal A (HR = 1.2, 95% CI, 1.0-1.3), Luminal B (HER2+) (HR = 1.3, 95% CI, 1.0-1.7), and TN breast cancer (HR = 1.4, 95% CI, 1.0-1.9). No clear association was found for birth weight and head circumference. The positive associations of birth length were restricted to women whose mothers were relatively tall (above population median). CONCLUSION: We found a positive association of birth length with risk of Luminal A, Luminal B (HER2+) and TN breast cancer that appears to be restricted to women whose mothers were relatively tall. This may support the hypothesis that breast cancer risk is influenced by determinants of longitudinal growth and that this finding deserves further scrutiny.
BACKGROUND: Because birth size appears to be positively associated with breast cancer risk, we have studied whether this risk may differ according to molecular breast cancer subtypes. METHODS: A cohort of 22,931 women born 1920-1966 were followed up for breast cancer occurrence from 1961 to 2012, and 870 were diagnosed during follow-up. Archival diagnostic material from 537 patients was available to determine molecular breast cancer subtype, specified as Luminal A, Luminal B (humanepidermal growth factor receptor 2 (HER2)-), Luminal B (HER2+), HER2 type, and Triple negative (TN) breast cancer. Information on the women's birth weight, birth length and head circumference at birth was used to estimate hazard ratios (HR) with 95% confidence intervals (CI) for each molecular subtype, applying Cox regression, and stratified by maternal height. RESULTS: Birth length (per 2 cm increments) was positively associated with Luminal A (HR = 1.2, 95% CI, 1.0-1.3), Luminal B (HER2+) (HR = 1.3, 95% CI, 1.0-1.7), and TN breast cancer (HR = 1.4, 95% CI, 1.0-1.9). No clear association was found for birth weight and head circumference. The positive associations of birth length were restricted to women whose mothers were relatively tall (above population median). CONCLUSION: We found a positive association of birth length with risk of Luminal A, Luminal B (HER2+) and TN breast cancer that appears to be restricted to women whose mothers were relatively tall. This may support the hypothesis that breast cancer risk is influenced by determinants of longitudinal growth and that this finding deserves further scrutiny.
Authors: Rulla M Tamimi; Graham A Colditz; Aditi Hazra; Heather J Baer; Susan E Hankinson; Bernard Rosner; Jonathan Marotti; James L Connolly; Stuart J Schnitt; Laura C Collins Journal: Breast Cancer Res Treat Date: 2011-08-10 Impact factor: 4.872
Authors: Robert N Hoover; Marianne Hyer; Ruth M Pfeiffer; Ervin Adam; Brian Bond; Andrea L Cheville; Theodore Colton; Patricia Hartge; Elizabeth E Hatch; Arthur L Herbst; Beth Y Karlan; Raymond Kaufman; Kenneth L Noller; Julie R Palmer; Stanley J Robboy; Robert C Saal; William Strohsnitter; Linda Titus-Ernstoff; Rebecca Troisi Journal: N Engl J Med Date: 2011-10-06 Impact factor: 91.245
Authors: Marit Valla; Lars Johan Vatten; Monica Jernberg Engstrøm; Olav Anton Haugen; Lars Andreas Akslen; Johan Håkon Bjørngaard; Anne Irene Hagen; Borgny Ytterhus; Anna Mary Bofin; Signe Opdahl Journal: Cancer Epidemiol Biomarkers Prev Date: 2016-09-26 Impact factor: 4.254
Authors: Renée T Fortner; Julia Sisti; Boyang Chai; Laura C Collins; Bernard Rosner; Susan E Hankinson; Rulla M Tamimi; A Heather Eliassen Journal: Breast Cancer Res Date: 2019-03-12 Impact factor: 6.466
Authors: P Lagiou; C C Hsieh; L Lipworth; E Samoli; W Okulicz; R Troisi; B Xu; P Hall; A Ekbom; H O Adami; D Trichopoulos Journal: Br J Cancer Date: 2009-05-05 Impact factor: 7.640
Authors: Sue Kyung Park; Daehee Kang; Katherine A McGlynn; Montserrat Garcia-Closas; Yeonju Kim; Keun Young Yoo; Louise A Brinton Journal: Breast Cancer Res Date: 2008-01-21 Impact factor: 6.466