| Literature DB >> 33753745 |
Natansh D Modi1, Jin Quan Eugene Tan2, Andrew Rowland2, Bogda Koczwara2,3, Ahmad Y Abuhelwa2, Ganessan Kichenadasse2, Ross A McKinnon2, Michael D Wiese4, Michael J Sorich2, Ashley M Hopkins2.
Abstract
While many studies have evaluated the relationship between BMI and breast cancer outcomes, it is unclear whether this relationship is consistent between early breast cancer (BC) and advanced BC. The study included 5099 patients with HER2 positive early BC (EBC) and 3496 with HER2 positive advanced BC (ABC). In the EBC cohort, higher BMI was associated with worse overall survival (OS) (HR [95% CI]: overweight = 1.30 [1.13-1.51]; obese = 1.37 [1.14-1.64], P = < 0.001), and worse disease-free survival (overweight = 1.10 [0.98-1.24]; obese = 1.20 [1.04-1.39], P = 0.061). In contrast, for the ABC cohort, higher BMI was significantly associated with improved OS (overweight = 0.85 [0.76-0.96]; obese = 0.82 [0.72-0.95], P = 0.014), and progression-free survival (overweight = 0.91 [0.83-1.01]; obese = 0.87 [0.77-0.98], P = 0.034). In this large high-quality dataset, higher BMI was independently associated with worse survival in EBC, paradoxically in ABC higher BMI was independently associated with improved survival.Entities:
Year: 2021 PMID： 33753745 PMCID： PMC7985140 DOI： 10.1038/s41523-021-00241-9
Source DB: PubMed Journal: NPJ Breast Cancer ISSN： 2374-4677