Literature DB >> 26545405

Body Mass Index at Diagnosis and Breast Cancer Survival Prognosis in Clinical Trial Populations from NRG Oncology/NSABP B-30, B-31, B-34, and B-38.

Reena S Cecchini1, Sandra M Swain2, Joseph P Costantino3, Priya Rastogi4, Jong-Hyeon Jeong3, Stewart J Anderson3, Gong Tang3, Charles E Geyer5, Barry C Lembersky4, Edward H Romond6, Alexander H G Paterson7, Norman Wolmark8.   

Abstract

BACKGROUND: Body mass index (BMI) has been associated with breast cancer outcomes. However, few studies used clinical trial settings where treatments and outcomes are consistently evaluated and documented. There are also limited data assessing how patient/disease characteristics and treatment may alter the BMI-breast cancer association.
METHODS: We evaluated 15,538 breast cancer participants from four NSABP protocols. B-34 studied early-stage breast cancer patients (N = 3,311); B-30 and B-38 included node-positive breast cancer patients (N = 5,265 and 4,860); and B-31 studied node-positive and HER2-positive breast cancer patients (N = 2,102). We used Cox proportional hazards regression to calculate adjusted hazards ratios (HR) for risk of death and recurrence, and conducted separate analyses by estrogen receptor (ER) status and treatment group.
RESULTS: In B-30, increased BMI was significantly related to survival. Compared with BMI < 25, HRs were 1.04 for BMI 25 to 29.9 and 1.18 for BMI ≥ 30 (P = 0.02). Separate analyses indicated the significant relationship was only in ER-positive disease (P = 0.002) and the subgroup treated with doxorubicin/cyclophosphamide (P = 0.005). There were no significant trends across BMI for the other three trials. Similar results were found for recurrence. Increased BMI was significantly related to recurrence in B-30 (P = 0.03); and the significant relationship was only in ER-positive breast cancers (P = 0.001). Recurrence was also significant among ER-positive disease in B-38 (P = 0.03).
CONCLUSIONS: In our investigation, we did not find a consistent relationship between BMI at diagnosis and breast cancer recurrence or death. IMPACT: This work demonstrates that the heterogeneity of breast cancer between different breast cancer populations and the different therapies used to treat them may modify any association that exists between BMI and breast cancer outcome. ©2015 American Association for Cancer Research.

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Year:  2015        PMID： 26545405      PMCID： PMC4713289          DOI： 10.1158/1055-9965.EPI-15-0334-T

Source DB:  PubMed          Journal:  Cancer Epidemiol Biomarkers Prev        ISSN： 1055-9965            Impact factor:   4.254


  38 in total

1.  Obesity and breast cancer survival in ethnically diverse postmenopausal women: the Multiethnic Cohort Study.

Authors:  Shannon M Conroy; Gertraud Maskarinec; Lynne R Wilkens; Kami K White; Brian E Henderson; Laurence N Kolonel
Journal:  Breast Cancer Res Treat       Date:  2011-04-16       Impact factor: 4.872

2.  Effects of obesity and race on prognosis in lymph node-negative, estrogen receptor-negative breast cancer.

Authors:  James J Dignam; Kelly Wieand; Karen A Johnson; Peter Raich; Stewart J Anderson; Carol Somkin; D Lawrence Wickerham
Journal:  Breast Cancer Res Treat       Date:  2005-12-06       Impact factor: 4.872

3.  Body size and risk of breast cancer.

Authors:  A Trentham-Dietz; P A Newcomb; B E Storer; M P Longnecker; J Baron; E R Greenberg; W C Willett
Journal:  Am J Epidemiol       Date:  1997-06-01       Impact factor: 4.897

4.  Obesity, diabetes, and survival outcomes in a large cohort of early-stage breast cancer patients.

Authors:  S Jiralerspong; E S Kim; W Dong; L Feng; G N Hortobagyi; S H Giordano
Journal:  Ann Oncol       Date:  2013-06-21       Impact factor: 32.976

5.  The impact of obesity on breast cancer: a retrospective review.

Authors:  Danielle J Haakinson; Steven G Leeds; Amylou C Dueck; Richard J Gray; Nabil Wasif; Chee-Chee H Stucky; Donald W Northfelt; Heidi A Apsey; Barbara Pockaj
Journal:  Ann Surg Oncol       Date:  2012-03-27       Impact factor: 5.344

6.  Effect of obesity on prognosis after early-stage breast cancer.

Authors:  Marianne Ewertz; Maj-Britt Jensen; Katrín Á Gunnarsdóttir; Inger Højris; Erik H Jakobsen; Dorte Nielsen; Lars E Stenbygaard; Ulla B Tange; Søren Cold
Journal:  J Clin Oncol       Date:  2010-11-29       Impact factor: 44.544

7.  Longitudinal study on the role of body size in premenopausal breast cancer.

Authors:  Karin B Michels; Kathryn L Terry; Walter C Willett
Journal:  Arch Intern Med       Date:  2006-11-27

8.  Obesity and weight change in relation to breast cancer survival.

Authors:  Xiaoli Chen; Wei Lu; Wei Zheng; Kai Gu; Zhi Chen; Ying Zheng; Xiao Ou Shu
Journal:  Breast Cancer Res Treat       Date:  2010-01-08       Impact factor: 4.872

9.  The effect of body mass index on overall and disease-free survival in node-positive breast cancer patients treated with docetaxel and doxorubicin-containing adjuvant chemotherapy: the experience of the BIG 02-98 trial.

Authors:  Evandro de Azambuja; Worta McCaskill-Stevens; Prudence Francis; Emmanuel Quinaux; John P A Crown; Malou Vicente; Rosa Giuliani; Bo Nordenskjöld; Jorge Gutiérez; Michael Andersson; Mireia Margeli Vila; Raimund Jakesz; Jan Demol; Joanna Dewar; Armando Santoro; Ana Lluch; Steven Olsen; Richard D Gelber; Angelo Di Leo; Martine Piccart-Gebhart
Journal:  Breast Cancer Res Treat       Date:  2010-01       Impact factor: 4.872

10.  Definitive results of a phase III adjuvant trial comparing three chemotherapy regimens in women with operable, node-positive breast cancer: the NSABP B-38 trial.

Authors:  Sandra M Swain; Gong Tang; Charles E Geyer; Priya Rastogi; James N Atkins; Paul P Donnellan; Louis Fehrenbacher; Catherine A Azar; André Robidoux; Jonathan A Polikoff; Adam M Brufsky; David D Biggs; Edward A Levine; John L Zapas; Louise Provencher; Donald W Northfelt; Soonmyung Paik; Joseph P Costantino; Eleftherios P Mamounas; Norman Wolmark
Journal:  J Clin Oncol       Date:  2013-08-12       Impact factor: 44.544
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  16 in total

Review 1.  The Impact of Diet on Breast Cancer Outcomes.

Authors:  Lai Xu; Lindsay L Peterson
Journal:  Curr Nutr Rep       Date:  2019-09

2.  Longitudinal patterns and associated factors of postdiagnosis weight changes in Korean breast cancer survivors with normal body mass index.

Authors:  Yul Ha Min; Jong Won Lee; Il Yong Chung; Sei Hyun Ahn
Journal:  Support Care Cancer       Date:  2017-04-04       Impact factor: 3.603

3.  Vascular density of histologically benign breast tissue from women with breast cancer: associations with tissue composition and tumor characteristics.

Authors:  Ashley M Fuller; Linnea T Olsson; Bentley R Midkiff; Erin L Kirk; Kirk K McNaughton; Benjamin C Calhoun; Melissa A Troester
Journal:  Hum Pathol       Date:  2019-07-02       Impact factor: 3.466

4.  Impact of body composition on outcome in patients with early breast cancer.

Authors:  Elise Deluche; Sophie Leobon; Jean Claude Desport; Laurence Venat-Bouvet; Julie Usseglio; Nicole Tubiana-Mathieu
Journal:  Support Care Cancer       Date:  2017-09-25       Impact factor: 3.603

5.  Interaction between body mass index and hormone-receptor status as a prognostic factor in lymph-node-positive breast cancer.

Authors:  Il Yong Chung; Jong Won Lee; Ji Sung Lee; Yu Rang Park; Yul Ha Min; Yura Lee; Tae In Yoon; Guiyun Sohn; Sae Byul Lee; Jisun Kim; Hee Jeong Kim; Beom Seok Ko; Byung Ho Son; Sei Hyun Ahn
Journal:  PLoS One       Date:  2017-03-01       Impact factor: 3.240

6.  Body mass index and breast cancer survival: a Mendelian randomization analysis.

Authors:  Qi Guo; Stephen Burgess; Constance Turman; Manjeet K Bolla; Qin Wang; Michael Lush; Jean Abraham; Kristiina Aittomäki; Irene L Andrulis; Carmel Apicella; Volker Arndt; Myrto Barrdahl; Javier Benitez; Christine D Berg; Carl Blomqvist; Stig E Bojesen; Bernardo Bonanni; Judith S Brand; Hermann Brenner; Annegien Broeks; Barbara Burwinkel; Carlos Caldas; Daniele Campa; Federico Canzian; Jenny Chang-Claude; Stephen J Chanock; Suet-Feung Chin; Fergus J Couch; Angela Cox; Simon S Cross; Cezary Cybulski; Kamila Czene; Hatef Darabi; Peter Devilee; W Ryan Diver; Alison M Dunning; Helena M Earl; Diana M Eccles; Arif B Ekici; Mikael Eriksson; D Gareth Evans; Peter A Fasching; Jonine Figueroa; Dieter Flesch-Janys; Henrik Flyger; Susan M Gapstur; Mia M Gaudet; Graham G Giles; Gord Glendon; Mervi Grip; Jacek Gronwald; Lothar Haeberle; Christopher A Haiman; Per Hall; Ute Hamann; Susan Hankinson; Jaana M Hartikainen; Alexander Hein; Louise Hiller; Frans B Hogervorst; Bernd Holleczek; Maartje J Hooning; Robert N Hoover; Keith Humphreys; David J Hunter; Anika Hüsing; Anna Jakubowska; Arja Jukkola-Vuorinen; Rudolf Kaaks; Maria Kabisch; Vesa Kataja; Julia A Knight; Linetta B Koppert; Veli-Matti Kosma; Vessela N Kristensen; Diether Lambrechts; Loic Le Marchand; Jingmei Li; Annika Lindblom; Sara Lindström; Jolanta Lissowska; Jan Lubinski; Mitchell J Machiela; Arto Mannermaa; Siranoush Manoukian; Sara Margolin; Federik Marme; John W M Martens; Catriona McLean; Primitiva Menéndez; Roger L Milne; Anna Marie Mulligan; Taru A Muranen; Heli Nevanlinna; Patrick Neven; Sune F Nielsen; Børge G Nordestgaard; Janet E Olson; Jose I A Perez; Paolo Peterlongo; Kelly-Anne Phillips; Christopher J Poole; Katri Pylkäs; Paolo Radice; Nazneen Rahman; Thomas Rüdiger; Anja Rudolph; Elinor J Sawyer; Fredrick Schumacher; Petra Seibold; Caroline Seynaeve; Mitul Shah; Ann Smeets; Melissa C Southey; Rob A E M Tollenaar; Ian Tomlinson; Helen Tsimiklis; Hans-Ulrich Ulmer; Celine Vachon; Ans M W van den Ouweland; Laura J Van't Veer; Hans Wildiers; Walter Willett; Robert Winqvist; M Pilar Zamora; Georgia Chenevix-Trench; Thilo Dörk; Douglas F Easton; Montserrat García-Closas; Peter Kraft; John L Hopper; Wei Zheng; Marjanka K Schmidt; Paul D P Pharoah
Journal:  Int J Epidemiol       Date:  2017-12-01       Impact factor: 7.196

7.  The obesity paradox in early and advanced HER2 positive breast cancer: pooled analysis of clinical trial data.

Authors:  Natansh D Modi; Jin Quan Eugene Tan; Andrew Rowland; Bogda Koczwara; Ahmad Y Abuhelwa; Ganessan Kichenadasse; Ross A McKinnon; Michael D Wiese; Michael J Sorich; Ashley M Hopkins
Journal:  NPJ Breast Cancer       Date:  2021-03-22

8.  Association of Obesity With Survival Outcomes in Patients With Cancer: A Systematic Review and Meta-analysis.

Authors:  Fausto Petrelli; Alessio Cortellini; Alice Indini; Gianluca Tomasello; Michele Ghidini; Olga Nigro; Massimiliano Salati; Lorenzo Dottorini; Alessandro Iaculli; Antonio Varricchio; Valentina Rampulla; Sandro Barni; Mary Cabiddu; Antonio Bossi; Antonio Ghidini; Alberto Zaniboni
Journal:  JAMA Netw Open       Date:  2021-03-01

9.  Impact of baseline BMI and weight change in CCTG adjuvant breast cancer trials.

Authors:  R Yerushalmi; B Dong; J W Chapman; P E Goss; M N Pollak; M J Burnell; M N Levine; V H C Bramwell; K I Pritchard; T J Whelan; J N Ingle; L E Shepherd; W R Parulekar; L Han; K Ding; K A Gelmon
Journal:  Ann Oncol       Date:  2017-07-01       Impact factor: 32.976

10.  Impact of Body Mass Index on Local Recurrence according to Intrinsic Subtype Approximation in Korean Women with Early Stage Invasive Breast Cancer Receiving Contemporary Treatments.

Authors:  Sang-Won Kim; Mison Chun; Yong Sik Jung; Young-Taek Oh; O Kyu Noh; Oyeon Cho
Journal:  J Cancer       Date:  2021-06-01       Impact factor: 4.207
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