| Literature DB >> 33750778 |
Lander Willem1, Steven Abrams2,3, Pieter J K Libin2,4,5, Pietro Coletti2, Elise Kuylen6,2, Oana Petrof2, Signe Møgelmose2,7, James Wambua2, Sereina A Herzog6, Christel Faes2, Philippe Beutels6,8, Niel Hens6,2.
Abstract
The COVID-19 pandemic caused many governments to impose policies restricting social interactions. A controlled and persistent release of lockdown measures covers many potential strategies and is subject to extensive scenario analyses. Here, we use an individual-based model (STRIDE) to simulate interactions between 11 million inhabitants of Belgium at different levels including extended household settings, i.e., "household bubbles". The burden of COVID-19 is impacted by both the intensity and frequency of physical contacts, and therefore, household bubbles have the potential to reduce hospital admissions by 90%. In addition, we find that it is crucial to complete contact tracing 4 days after symptom onset. Assumptions on the susceptibility of children affect the impact of school reopening, though we find that business and leisure-related social mixing patterns have more impact on COVID-19 associated disease burden. An optimal deployment of the mitigation policies under study require timely compliance to physical distancing, testing and self-isolation.Entities:
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Year: 2021 PMID: 33750778 PMCID: PMC7943552 DOI: 10.1038/s41467-021-21747-7
Source DB: PubMed Journal: Nat Commun ISSN: 2041-1723 Impact factor: 14.919