| Literature DB >> 33730321 |
Tomoko Horinouchi1, Kaori Maeyama1,2, Masashi Nagai1,3, Masami Mizobuchi4, Yasuko Takagi5, Yuka Okada6, Takeshi Kato7, Mio Nishimura8, Yoko Kawasaki8, Mieko Yoshioka5, Satoshi Takada5, Hisayuki Matsumoto9, Yuji Nakamachi9, Jun Saegusa9, Sachiyo Fukushima1, Kazumichi Fujioka1, Kazumi Tomioka1, Hiroaki Nagase1, Kandai Nozu1, Kazumoto Iijima1, Noriyuki Nishimura10.
Abstract
Neonatal jaundice has been suggested as a perinatal risk factor for autism spectrum disorder (ASD). We examined UGT1A1 polymorphisms to assess the potential of neonatal jaundice as a risk factor for ASD in children by using DNA extracted from preserved umbilical cord. In total, 79 children with ASD were genotyped for UGT1A1*28 (c.-41-40dup), UGT1A1*6 (c.211 G > A), and UGT1A1*27 (c.686 C > A). The allele frequency of UGT1A1*6 (OR = 1.34, p = 0.26) and UGT1A1*28 (OR = 0.80, p = 0.54) and the prevalence of UGT1A1*28/*6 diplotypes did not differ significantly from those in the control population. No UGT1A1*27 allele was detected in the subjects. ASD symptom assessment scores were not associated with UGT1A1*28/*6/*27 genotypes or UGT1A1*28/*6 diplotypes. These results suggest that neonatal jaundice is not significantly associated with ASD.Entities:
Keywords: Autism spectrum disorder; Dried umbilical cord; Neonatal jaundice; Polymorphism; UGT1A1
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Year: 2021 PMID： 33730321 DOI： 10.1007/s10803-021-04941-w
Source DB: PubMed Journal: J Autism Dev Disord ISSN： 0162-3257