Christina Cordero1, Laura A Schieve2, Lisa A Croen3, Stephanie M Engel4, Anna Maria Siega-Riz4,5, Amy H Herring4,6, Catherine J Vladutiu4, Carl J Seashore7, Julie L Daniels4. 1. Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA. c.cordero@med.miami.edu. 2. National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA, USA. 3. Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA. 4. Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA. 5. Department of Family, Community & Mental Health Systems, University of Virginia, Charlottesville, VA, USA. 6. Department of Statistical Science, Duke University, Durham, NC, USA. 7. Department of Pediatrics, University of North Carolina, Chapel Hill, NC, USA.
Abstract
OBJECTIVE: To examine the association between neonatal jaundice and autism spectrum disorder (ASD) and non-ASD developmental disorder (DD). STUDY DESIGN: We analyzed data from the Study to Explore Early Development, a US multisite, case-control study conducted from 2007 to 2011. Developmental assessment classified children aged 2-5 years into: ASD (n = 636), DD (n = 777), or controls (POP; n = 926). Neonatal jaundice (n = 1054) was identified from medical records and maternal interviews. We examined associations between neonatal jaundice and ASD and DD using regression models to obtain adjusted odds ratios (aOR). RESULTS: Our results showed interaction between gestational age and neonatal jaundice. Neonatal jaundice was associated with ASD at 35-37 weeks (aOR = 1.83, 95%CI 1.05, 3.19), but not ≥38 weeks gestation (aOR = 0.97, 95%CI 0.76, 1.24). Similar results were observed with DD. CONCLUSIONS: Further exploration of timing and severity of neonatal jaundice and ASD/DD is warranted.
OBJECTIVE: To examine the association between neonatal jaundice and autism spectrum disorder (ASD) and non-ASD developmental disorder (DD). STUDY DESIGN: We analyzed data from the Study to Explore Early Development, a US multisite, case-control study conducted from 2007 to 2011. Developmental assessment classified children aged 2-5 years into: ASD (n = 636), DD (n = 777), or controls (POP; n = 926). Neonatal jaundice (n = 1054) was identified from medical records and maternal interviews. We examined associations between neonatal jaundice and ASD and DD using regression models to obtain adjusted odds ratios (aOR). RESULTS: Our results showed interaction between gestational age and neonatal jaundice. Neonatal jaundice was associated with ASD at 35-37 weeks (aOR = 1.83, 95%CI 1.05, 3.19), but not ≥38 weeks gestation (aOR = 0.97, 95%CI 0.76, 1.24). Similar results were observed with DD. CONCLUSIONS: Further exploration of timing and severity of neonatal jaundice and ASD/DD is warranted.
Authors: Ekomobong E Eyoh; Michelle D Failla; Zachary J Williams; Kyle L Schwartz; Laurie E Cutting; Bennett A Landman; Carissa J Cascio Journal: J Autism Dev Disord Date: 2021-12-01