Jonathan M Holmes1, Amra Hercinovic2, B Michele Melia2, David A Leske3, Sarah R Hatt3, Danielle L Chandler2, Trevano W Dean2, Raymond T Kraker2, Laura B Enyedi4, David K Wallace5, Brian G Mohney3, Susan A Cotter6. 1. Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota; Department of Ophthalmology and Vision Science, University of Arizona-Tucson, Tucson, Arizona. Electronic address: jmholmes@arizona.edu. 2. Jaeb Center for Health Research, Tampa, Florida. 3. Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota. 4. Duke University Eye Center, Durham, North Carolina. 5. Glick Eye Institute, Indiana University School of Medicine, Indianapolis, Indiana. 6. Southern California College of Optometry at Marshall B. Ketchum University, Fullerton, California.
Abstract
PURPOSE: To determine whether health-related quality of life (HRQOL) scores improved or worsened over 3 years of observation in childhood intermittent exotropia without treatment. METHODS: A total of 111 children aged 3-11 years with intermittent exotropia were assigned to observation in a previously reported randomized trial comparing patching with observation. The intermittent exotropia questionnaire (IXTQ) was administered at baseline, 6 months, and 36 months. Rasch-calibrated IXTQ domain scores (Child, Proxy, Parent-psychosocial, Parent-function, and Parent-surgery) were compared between time points. The Child IXTQ was administered only to children ≥5 years of age (n = 78). RESULTS: Overall, Child IXTQ and Proxy IXTQ scores showed no significant change over 36 months (mean improvement from baseline to 36 months of 3.2 points [95% CI, -1.9 to 8.2] and -2.4 points [95% CI: -7.9 to 3.1], resp.). By contrast, Parent-psychosocial, Parent-function, and Parent-surgery domain scores all improved over 36 months (mean improvements of 12.8 points [95% CI, 5.9-19.6] and 14.2 points [95% CI, 8.0-20.3] and 18.5 points [95% CI, 9.7-27.3], resp.). CONCLUSIONS: HRQOL of children with intermittent exotropia remains stable with observation over 3 years (by both child and proxy report), whereas parental HRQOL improves.
PURPOSE: To determine whether health-related quality of life (HRQOL) scores improved or worsened over 3 years of observation in childhood intermittent exotropia without treatment. METHODS: A total of 111 children aged 3-11 years with intermittent exotropia were assigned to observation in a previously reported randomized trial comparing patching with observation. The intermittent exotropia questionnaire (IXTQ) was administered at baseline, 6 months, and 36 months. Rasch-calibrated IXTQ domain scores (Child, Proxy, Parent-psychosocial, Parent-function, and Parent-surgery) were compared between time points. The Child IXTQ was administered only to children ≥5 years of age (n = 78). RESULTS: Overall, Child IXTQ and Proxy IXTQ scores showed no significant change over 36 months (mean improvement from baseline to 36 months of 3.2 points [95% CI, -1.9 to 8.2] and -2.4 points [95% CI: -7.9 to 3.1], resp.). By contrast, Parent-psychosocial, Parent-function, and Parent-surgery domain scores all improved over 36 months (mean improvements of 12.8 points [95% CI, 5.9-19.6] and 14.2 points [95% CI, 8.0-20.3] and 18.5 points [95% CI, 9.7-27.3], resp.). CONCLUSIONS: HRQOL of children with intermittent exotropia remains stable with observation over 3 years (by both child and proxy report), whereas parental HRQOL improves.
Authors: Michael Clarke; Vanessa Hogan; Deborah Buck; Jing Shen; Christine Powell; Chris Speed; Peter Tiffin; John Sloper; Robert Taylor; Mahmoud Nassar; Kerry Joyce; Fiona Beyer; Richard Thomson; Luke Vale; Elaine McColl; Nick Steen Journal: Health Technol Assess Date: 2015-05 Impact factor: 4.014
Authors: Susan A Cotter; Brian G Mohney; Danielle L Chandler; Jonathan M Holmes; Michael X Repka; Michele Melia; David K Wallace; Roy W Beck; Eileen E Birch; Raymond T Kraker; Susanna M Tamkins; Aaron M Miller; Nicholas A Sala; Stephen R Glaser Journal: Ophthalmology Date: 2014-09-16 Impact factor: 12.079
Authors: Brian G Mohney; Susan A Cotter; Danielle L Chandler; Jonathan M Holmes; David K Wallace; Tomohiko Yamada; David B Petersen; Raymond T Kraker; Christie L Morse; B Michele Melia; Rui Wu Journal: Ophthalmology Date: 2019-01-26 Impact factor: 12.079
Authors: Sarah R Hatt; David A Leske; Tomohiko Yamada; Elizabeth A Bradley; Stephen R Cole; Jonathan M Holmes Journal: Ophthalmology Date: 2009-11-06 Impact factor: 12.079
Authors: Sean P Donahue; Danielle L Chandler; Jonathan M Holmes; Brian W Arthur; Evelyn A Paysse; David K Wallace; David B Petersen; B Michele Melia; Raymond T Kraker; Aaron M Miller Journal: Ophthalmology Date: 2018-09-03 Impact factor: 12.079
Authors: Jonathan M Holmes; Amra Hercinovic; B Michele Melia; David A Leske; Sarah R Hatt; Danielle L Chandler; Trevano W Dean; Raymond T Kraker; Laura B Enyedi; David K Wallace; Sean P Donahue; Susan A Cotter Journal: J AAPOS Date: 2021-04-24 Impact factor: 1.220