Jonathan M Holmes1, Amra Hercinovic2, B Michele Melia2, David A Leske3, Sarah R Hatt3, Danielle L Chandler2, Trevano W Dean2, Raymond T Kraker2, Laura B Enyedi4, David K Wallace5, Sean P Donahue6, Susan A Cotter7. 1. Department of Ophthalmology and Vision Science, University of Arizona-Tucson. Electronic address: jmholmes@arizona.edu. 2. Jaeb Center for Health Research, Tampa, Florida. 3. Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota. 4. Duke University Eye Center, Durham, NC. 5. Glick Eye Institute, Indiana University School of Medicine, Indianapolis, Indiana. 6. Department of Ophthalmology and Visual Sciences, Vanderbilt University Medical Center, Nashville, Tennessee. 7. Southern California College of Optometry at Marshall B. Ketchum University, Fullerton, California.
Abstract
PURPOSE: To investigate health-related quality of life (HRQOL) after strabismus surgery in children with intermittent exotropia (IXT) and relationships between HRQOL and surgical success. METHODS: A total of 197 children with IXT aged 3-11 years (and 1 parent of each child) were enrolled in a previously reported randomized clinical trial comparing two surgical procedures. The Intermittent Exotropia Questionnaire (IXTQ) was administered before surgery (baseline), and again at 6 and 36 months following surgery. The child version of the IXTQ was only completed by children 5-11 years of age (n = 123). Outcomes were classified as "resolved" (exodeviation of <10Δ, no decreased stereoacuity, and no other nonsurgical treatment for IXT or reoperation), "suboptimal" (exotropia ≥10Δ by simultaneous prism and cover test or constant esotropia ≥6Δ or loss of ≥2 octaves of stereoacuity), or "intermediate." Mean changes in Rasch-calibrated IXTQ domain scores (Child, Proxy, Parent-psychosocial, Parent-function, and Parent-surgery; converted to a 0-100 scale) were compared. RESULTS: Overall, mean IXTQ domain scores improved for all domains from baseline to 36 months after surgery, ranging from 10.7 points (Child IXTQ; P < 0.0001) to 34.5 points (Parent-surgery IXTQ; P < 0.0001). At 36 months after surgery, 62 (39%) children had resolved IXT, whereas 38 (24%) had suboptimal outcome. Greater improvement was found in all mean domain scores with resolved IXT (range, 19.8-46.0 points) compared with suboptimal outcome (all comparisons P < 0.05). CONCLUSIONS: Successful surgery for childhood IXT results in measurable improvement in a child's quality of life, in parental assessment of the child's quality of life, and in quality of life for the parent.
PURPOSE: To investigate health-related quality of life (HRQOL) after strabismus surgery in children with intermittent exotropia (IXT) and relationships between HRQOL and surgical success. METHODS: A total of 197 children with IXT aged 3-11 years (and 1 parent of each child) were enrolled in a previously reported randomized clinical trial comparing two surgical procedures. The Intermittent Exotropia Questionnaire (IXTQ) was administered before surgery (baseline), and again at 6 and 36 months following surgery. The child version of the IXTQ was only completed by children 5-11 years of age (n = 123). Outcomes were classified as "resolved" (exodeviation of <10Δ, no decreased stereoacuity, and no other nonsurgical treatment for IXT or reoperation), "suboptimal" (exotropia ≥10Δ by simultaneous prism and cover test or constant esotropia ≥6Δ or loss of ≥2 octaves of stereoacuity), or "intermediate." Mean changes in Rasch-calibrated IXTQ domain scores (Child, Proxy, Parent-psychosocial, Parent-function, and Parent-surgery; converted to a 0-100 scale) were compared. RESULTS: Overall, mean IXTQ domain scores improved for all domains from baseline to 36 months after surgery, ranging from 10.7 points (Child IXTQ; P < 0.0001) to 34.5 points (Parent-surgery IXTQ; P < 0.0001). At 36 months after surgery, 62 (39%) children had resolved IXT, whereas 38 (24%) had suboptimal outcome. Greater improvement was found in all mean domain scores with resolved IXT (range, 19.8-46.0 points) compared with suboptimal outcome (all comparisons P < 0.05). CONCLUSIONS: Successful surgery for childhood IXT results in measurable improvement in a child's quality of life, in parental assessment of the child's quality of life, and in quality of life for the parent.
Authors: Michael Clarke; Vanessa Hogan; Deborah Buck; Jing Shen; Christine Powell; Chris Speed; Peter Tiffin; John Sloper; Robert Taylor; Mahmoud Nassar; Kerry Joyce; Fiona Beyer; Richard Thomson; Luke Vale; Elaine McColl; Nick Steen Journal: Health Technol Assess Date: 2015-05 Impact factor: 4.014
Authors: Sarah R Hatt; David A Leske; Laura Liebermann; Kemuel L Philbrick; Jonathan M Holmes Journal: Ophthalmology Date: 2014-06-06 Impact factor: 12.079
Authors: Sarah R Hatt; David A Leske; Yolanda S Castañeda; Suzanne M Wernimont; Laura Liebermann; Christina S Cheng-Patel; Eileen E Birch; Jonathan M Holmes Journal: Am J Ophthalmol Date: 2019-01-14 Impact factor: 5.258
Authors: Sarah R Hatt; David A Leske; Tomohiko Yamada; Elizabeth A Bradley; Stephen R Cole; Jonathan M Holmes Journal: Ophthalmology Date: 2009-11-06 Impact factor: 12.079
Authors: Sean P Donahue; Danielle L Chandler; Jonathan M Holmes; Brian W Arthur; Evelyn A Paysse; David K Wallace; David B Petersen; B Michele Melia; Raymond T Kraker; Aaron M Miller Journal: Ophthalmology Date: 2018-09-03 Impact factor: 12.079