Literature DB >> 3367921

Use of computerized data listings and activity profiles of genetic and related effects in the review of 195 compounds.

M D Waters1, H F Stack, A L Brady, P H Lohman, L Haroun, H Vainio.   

Abstract

Computer-generated listings of data from short-term tests for genetic and related effects (activity profile listings) were prepared for 195 compounds that included for each compound, the test system (identified by a three-letter code word), qualitative results and the lowest effective dose (LED) or highest ineffective dose (HID) tested. A corresponding bar or line graph (activity profile) was also generated, in which test systems are displayed along the x-axis and the LED or HID values along the y-axis. The listings were reviewed and the data summarized by an IARC Working Group. The methodology used to generate these listings and plots is described, and results are given for one compound, benzene. The entire data base contains approximately 7000 entries from 4000 references.

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Year:  1988        PMID: 3367921     DOI: 10.1016/0165-1218(88)90024-9

Source DB:  PubMed          Journal:  Mutat Res        ISSN: 0027-5107            Impact factor:   2.433


  12 in total

Review 1.  Utility of short-term tests for genetic toxicity.

Authors:  D M DeMarini; J Lewtas; H E Brockman
Journal:  Cell Biol Toxicol       Date:  1989-06       Impact factor: 6.691

2.  Integrating publicly available information to screen potential candidates for chemical prioritization under the Toxic Substances Control Act: A proof of concept case study using genotoxicity and carcinogenicity.

Authors:  Grace Patlewicz; Jeffry L Dean; Catherine F Gibbons; Richard S Judson; Nagalakshmi Keshava; Leora Vegosen; Todd M Martin; Prachi Pradeep; Anita Simha; Sarah H Warren; Maureen R Gwinn; David M DeMarini
Journal:  Comput Toxicol       Date:  2021-11-01

3.  Interphase cytogenetics of workers exposed to benzene.

Authors:  L Zhang; N Rothman; Y Wang; R B Hayes; W Bechtold; P Venkatesh; S Yin; Y Wang; M Dosemeci; G Li; W Lu; M T Smith
Journal:  Environ Health Perspect       Date:  1996-12       Impact factor: 9.031

4.  Benzene induces gene-duplicating but not gene-inactivating mutations at the glycophorin A locus in exposed humans.

Authors:  N Rothman; R Haas; R B Hayes; G L Li; J Wiemels; S Campleman; P J Quintana; L J Xi; M Dosemeci; N Titenko-Holland
Journal:  Proc Natl Acad Sci U S A       Date:  1995-04-25       Impact factor: 11.205

5.  Inhibition of human topoisomerase II in vitro by bioactive benzene metabolites.

Authors:  C E Frantz; H Chen; D A Eastmond
Journal:  Environ Health Perspect       Date:  1996-12       Impact factor: 9.031

6.  Human exposures to mutagens--an analysis using the genetic activity profile database.

Authors:  R R Tice; H F Stack; M D Waters
Journal:  Environ Health Perspect       Date:  1996-05       Impact factor: 9.031

7.  The Genetic Activity Profile database.

Authors:  M D Waters; H F Stack; N E Garrett; M A Jackson
Journal:  Environ Health Perspect       Date:  1991-12       Impact factor: 9.031

8.  A proposed method for assembly and interpretation of short-term test data.

Authors:  D Brusick
Journal:  Environ Health Perspect       Date:  1991-12       Impact factor: 9.031

9.  Chemical interaction: enhancement and inhibition of clastogenicity.

Authors:  W A Anwar
Journal:  Environ Health Perspect       Date:  1993-10       Impact factor: 9.031

Review 10.  Perspectives on the risk assessment for nongenotoxic carcinogens and tumor promoters.

Authors:  F P Perera
Journal:  Environ Health Perspect       Date:  1991-08       Impact factor: 9.031

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