Qixuan Wang1,2,3, Xueling Wang1,2,3,4, Lu Yang1,2,3, Kun Han1,2,3, Zhiwu Huang5,6,7, Hao Wu8,9,10. 1. Department of Otolaryngology-Head and Neck Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, 639 ZhiZaoJu Road, HuangPu District, Shanghai, 200011, People's Republic of China. 2. Ear Institute, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, People's Republic of China. 3. Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, 200011, People's Republic of China. 4. Biobank, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, People's Republic of China. 5. Department of Otolaryngology-Head and Neck Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, 639 ZhiZaoJu Road, HuangPu District, Shanghai, 200011, People's Republic of China. huangzw86@126.com. 6. Ear Institute, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, People's Republic of China. huangzw86@126.com. 7. Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, 200011, People's Republic of China. huangzw86@126.com. 8. Department of Otolaryngology-Head and Neck Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, 639 ZhiZaoJu Road, HuangPu District, Shanghai, 200011, People's Republic of China. wuhao@shsmu.edu.cn. 9. Ear Institute, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, People's Republic of China. wuhao@shsmu.edu.cn. 10. Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, 200011, People's Republic of China. wuhao@shsmu.edu.cn.
Abstract
BACKGROUND: Significant sex differences exist in hearing physiology, while few human studies have investigated sex differences in noise-induced hearing loss (NIHL), and the sex bias in previous studies resulted in inadequate female data. The study aims to investigate sex differences in the characteristics of NIHL to provide insight into sex-specific risk factors, prevention strategies and treatment for NIHL. METHODS: This cross-sectional study included 2280 industrial noise-exposed shipyard workers (1140 males and 1140 females matched for age, job and employment length) in China. Individual noise exposure levels were measured to calculate the cumulative noise exposure (CNE), and an audiometric test was performed by an experienced technician in a soundproof booth. Sex differences in and influencing factors of low-frequency (LFHL) and high-frequency hearing loss (HFHL) were analyzed using logistic regression models stratified by age and CNE. RESULTS: At comparable noise exposure levels and ages, the prevalence of HFHL was significantly higher in males (34.4%) than in females (13.8%), and males had a higher prevalence of HFHL (OR = 4.19, 95% CI 3.18 to 5.52) after adjusting for age, CNE, and other covariates. Sex differences were constant and highly remarkable among subjects aged 30 to 40 years and those with a CNE of 80 to 95 dB(A). Alcohol consumption might be a risk factor for HFHL in females (OR = 3.12, 95% CI 1.10 to 8.89). CONCLUSIONS: This study indicates significant sex differences in NIHL. Males are at higher risk of HFHL than females despite equivalent noise exposure and age. The risk factors for NIHL might be different in males and females.
BACKGROUND: Significant sex differences exist in hearing physiology, while few human studies have investigated sex differences in noise-induced hearing loss (NIHL), and the sex bias in previous studies resulted in inadequate female data. The study aims to investigate sex differences in the characteristics of NIHL to provide insight into sex-specific risk factors, prevention strategies and treatment for NIHL. METHODS: This cross-sectional study included 2280 industrial noise-exposed shipyard workers (1140 males and 1140 females matched for age, job and employment length) in China. Individual noise exposure levels were measured to calculate the cumulative noise exposure (CNE), and an audiometric test was performed by an experienced technician in a soundproof booth. Sex differences in and influencing factors of low-frequency (LFHL) and high-frequency hearing loss (HFHL) were analyzed using logistic regression models stratified by age and CNE. RESULTS: At comparable noise exposure levels and ages, the prevalence of HFHL was significantly higher in males (34.4%) than in females (13.8%), and males had a higher prevalence of HFHL (OR = 4.19, 95% CI 3.18 to 5.52) after adjusting for age, CNE, and other covariates. Sex differences were constant and highly remarkable among subjects aged 30 to 40 years and those with a CNE of 80 to 95 dB(A). Alcohol consumption might be a risk factor for HFHL in females (OR = 3.12, 95% CI 1.10 to 8.89). CONCLUSIONS: This study indicates significant sex differences in NIHL. Males are at higher risk of HFHL than females despite equivalent noise exposure and age. The risk factors for NIHL might be different in males and females.
Entities:
Keywords:
Hearing loss; Occupational noise exposure; Sex differences
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