Literature DB >> 33675465

The role of ADRB2 gene polymorphisms in malignancies.

Yaqian Wang1, Shujuan Jiang2,3,4.   

Abstract

Beta-2-adrenergic receptor is a member of the G protein-coupled receptor superfamily, which is highly expressed in most malignancies. There is increasing evidence showing that beta-2-adrenergic receptors are associated with carcinogenesis, proliferation, immune regulation, invasion, angiogenesis, clinical prognosis and treatment resistance in malignancies. Polymorphisms of the ADRB2 gene have been confirmed to be associated with transcriptional activity, mRNA translation, and beta-2-adrenergic receptor expression and sensitivity. This review discusses clinically relevant examples of single nucleotide polymorphisms of ADRB2 in malignancies and the effects of these polymorphisms on cancer susceptibility, prognosis and treatment response of cancer patients.

Entities:  

Keywords:  ADRB2; Malignancy; Single nucleotide polymorphism; β2-Adrenergic receptor

Year:  2021        PMID： 33675465     DOI： 10.1007/s11033-021-06250-y

Source DB:  PubMed          Journal:  Mol Biol Rep        ISSN： 0301-4851            Impact factor:   2.316


  75 in total

Review 1.  Novel beta2-adrenergic receptor signaling pathways.

Authors:  Jeffrey L Benovic
Journal:  J Allergy Clin Immunol       Date:  2002-12       Impact factor: 10.793

Review 2.  Environmental immune disruptors, inflammation and cancer risk.

Authors:  Patricia A Thompson; Mahin Khatami; Carolyn J Baglole; Jun Sun; Shelley A Harris; Eun-Yi Moon; Fahd Al-Mulla; Rabeah Al-Temaimi; Dustin G Brown; Annamaria Colacci; Chiara Mondello; Jayadev Raju; Elizabeth P Ryan; Jordan Woodrick; A Ivana Scovassi; Neetu Singh; Monica Vaccari; Rabindra Roy; Stefano Forte; Lorenzo Memeo; Hosni K Salem; Amedeo Amedei; Roslida A Hamid; Leroy Lowe; Tiziana Guarnieri; William H Bisson
Journal:  Carcinogenesis       Date:  2015-06       Impact factor: 4.944

Review 3.  Structural and Biophysical Mechanisms of Class C G Protein-Coupled Receptor Function.

Authors:  Amr Ellaithy; Javier Gonzalez-Maeso; Diomedes A Logothetis; Joshua Levitz
Journal:  Trends Biochem Sci       Date:  2020-08-26       Impact factor: 13.807

4.  Assembly of a beta2-adrenergic receptor--GluR1 signalling complex for localized cAMP signalling.

Authors:  Mei-ling A Joiner; Marie-France Lisé; Eunice Y Yuen; Angel Y F Kam; Mingxu Zhang; Duane D Hall; Zulfiqar A Malik; Hai Qian; Yucui Chen; Jason D Ulrich; Alain C Burette; Richard J Weinberg; Ping-Yee Law; Alaa El-Husseini; Zhen Yan; Johannes W Hell
Journal:  EMBO J       Date:  2009-11-26       Impact factor: 11.598

5.  Exchange protein activated by cyclic-adenosine monophosphate (Epac) regulates atrial fibroblast function and controls cardiac remodelling.

Authors:  Sirirat Surinkaew; Mona Aflaki; Abhijit Takawale; Yu Chen; Xiao-Yan Qi; Marc-Antoine Gillis; Yan-Fen Shi; Jean-Claude Tardif; Nipon Chattipakorn; Stanley Nattel
Journal:  Cardiovasc Res       Date:  2019-01-01       Impact factor: 10.787

Review 6.  Losing balance: the origin and impact of aneuploidy in cancer.

Authors:  Andrew J Holland; Don W Cleveland
Journal:  EMBO Rep       Date:  2012-06-01       Impact factor: 8.807

7.  Modulation of beta2- and beta3-adrenoceptor-mediated relaxation of rat oesophagus smooth muscle by protein kinase C.

Authors:  Jaap Oostendorp; Peter Ph Obels; A Rene Terpstra; S Adriaan Nelemans; Johan Zaagsma
Journal:  Eur J Pharmacol       Date:  2004-07-08       Impact factor: 4.432

Review 8.  Postsynaptic localization and regulation of AMPA receptors and Cav1.2 by β2 adrenergic receptor/PKA and Ca2+/CaMKII signaling.

Authors:  Tommaso Patriarchi; Olivia R Buonarati; Johannes W Hell
Journal:  EMBO J       Date:  2018-09-24       Impact factor: 11.598

9.  Enhanced cardiac function in Gravin mutant mice involves alterations in the β-adrenergic receptor signaling cascade.

Authors:  Ashley N Guillory; Xing Yin; Cori S Wijaya; Andrea C Diaz Diaz; Abeer Rababa'h; Sonal Singh; Fatin Atrooz; Sakthivel Sadayappan; Bradley K McConnell
Journal:  PLoS One       Date:  2013-09-18       Impact factor: 3.240

10.  β2-adrenogenic signaling regulates NNK-induced pancreatic cancer progression via upregulation of HIF-1α.

Authors:  Dong Zhang; Jianjun Lei; Jiguang Ma; Xin Chen; Liang Sheng; Zhengdong Jiang; Ligang Nan; Qinhong Xu; Wanxing Duan; Zheng Wang; Xuqi Li; Zheng Wu; Erxi Wu; Qingyong Ma; Xiongwei Huo
Journal:  Oncotarget       Date:  2016-04-05
View more
  1 in total

1.  ADRB2 expression predicts the clinical outcomes and is associated with immune cells infiltration in lung adenocarcinoma.

Authors:  Lingyun Ji; Fei Xu; Jingtao Zhang; Ting Song; Weida Chen; Xi Yin; Qingqing Wang; Xiubao Chen; Xin Li; Minghao Guo; Zetao Chen
Journal:  Sci Rep       Date:  2022-09-26       Impact factor: 4.996
  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.