Literature DB >> 22565320

Losing balance: the origin and impact of aneuploidy in cancer.

Andrew J Holland1, Don W Cleveland.   

Abstract

Most solid human tumours are aneuploid, that is, they contain an abnormal number of chromosomes. Paradoxically, however, aneuploidy has been reported to induce a stress response that suppresses cellular proliferation in vitro. Here, we review the progress in our understanding of the causes and effects of aneuploidy in cancer and discuss how, in specific contexts, aneuploidy can provide a growth advantage and facilitate cellular transformation. We also explore the emerging possibilities for targeting the cause or consequences of aneuploidy therapeutically.

Entities:  

Mesh：

Year:  2012        PMID： 22565320      PMCID： PMC3367240          DOI： 10.1038/embor.2012.55

Source DB:  PubMed          Journal:  EMBO Rep        ISSN： 1469-221X            Impact factor:   8.807


  178 in total

1.  Chromosome instability is common in human cleavage-stage embryos.

Authors:  Evelyne Vanneste; Thierry Voet; Cédric Le Caignec; Michèle Ampe; Peter Konings; Cindy Melotte; Sophie Debrock; Mustapha Amyere; Miikka Vikkula; Frans Schuit; Jean-Pierre Fryns; Geert Verbeke; Thomas D'Hooghe; Yves Moreau; Joris R Vermeesch
Journal:  Nat Med       Date:  2009-04-26       Impact factor: 53.440

2.  Chromosomal instability is a risk factor for poor prognosis of adenocarcinoma of the lung: Fluorescence in situ hybridization analysis of paraffin-embedded tissue from Korean patients.

Authors:  Chang-Min Choi; Kwang Won Seo; Se Jin Jang; Yeon-Mok Oh; Tae-Sun Shim; Woo Sung Kim; Dong-Soon Lee; Sang-Do Lee
Journal:  Lung Cancer       Date:  2008-09-23       Impact factor: 5.705

3.  Multipolar spindle pole coalescence is a major source of kinetochore mis-attachment and chromosome mis-segregation in cancer cells.

Authors:  William T Silkworth; Isaac K Nardi; Lindsey M Scholl; Daniela Cimini
Journal:  PLoS One       Date:  2009-08-10       Impact factor: 3.240

4.  Chromosomal instability determines taxane response.

Authors:  Charles Swanton; Barbara Nicke; Marion Schuett; Aron C Eklund; Charlotte Ng; Qiyuan Li; Thomas Hardcastle; Alvin Lee; Rajat Roy; Philip East; Maik Kschischo; David Endesfelder; Paul Wylie; Se Nyun Kim; Jie-Guang Chen; Michael Howell; Thomas Ried; Jens K Habermann; Gert Auer; James D Brenton; Zoltan Szallasi; Julian Downward
Journal:  Proc Natl Acad Sci U S A       Date:  2009-05-19       Impact factor: 11.205

Review 5.  Chromosomal instability: a composite phenotype that influences sensitivity to chemotherapy.

Authors:  Sarah E McClelland; Rebecca A Burrell; Charles Swanton
Journal:  Cell Cycle       Date:  2009-10-31       Impact factor: 4.534

Review 6.  Boveri revisited: chromosomal instability, aneuploidy and tumorigenesis.

Authors:  Andrew J Holland; Don W Cleveland
Journal:  Nat Rev Mol Cell Biol       Date:  2009-07       Impact factor: 94.444

7.  Slow proliferation as a biological feature of colorectal cancer metastasis.

Authors:  A Anjomshoaa; S Nasri; B Humar; J L McCall; A Chatterjee; H-S Yoon; L McNoe; M A Black; A E Reeve
Journal:  Br J Cancer       Date:  2009-08-04       Impact factor: 7.640

8.  Down's syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1.

Authors:  Kwan-Hyuck Baek; Alexander Zaslavsky; Ryan C Lynch; Carmella Britt; Yoshiaki Okada; Richard J Siarey; M William Lensch; In-Hyun Park; Sam S Yoon; Takashi Minami; Julie R Korenberg; Judah Folkman; George Q Daley; William C Aird; Zygmunt Galdzicki; Sandra Ryeom
Journal:  Nature       Date:  2009-05-20       Impact factor: 49.962

9.  Loss of spindle assembly checkpoint-mediated inhibition of Cdc20 promotes tumorigenesis in mice.

Authors:  Min Li; Xiao Fang; Zhubo Wei; J Philippe York; Pumin Zhang
Journal:  J Cell Biol       Date:  2009-06-15       Impact factor: 10.539

10.  A mechanism linking extra centrosomes to chromosomal instability.

Authors:  Neil J Ganem; Susana A Godinho; David Pellman
Journal:  Nature       Date:  2009-06-07       Impact factor: 49.962
View more
  129 in total

Review 1.  Centrosomes in spindle organization and chromosome segregation: a mechanistic view.

Authors:  Patrick Meraldi
Journal:  Chromosome Res       Date:  2016-01       Impact factor: 5.239

2.  JNK signaling is needed to tolerate chromosomal instability.

Authors:  Heidi W-S Wong; Zeeshan Shaukat; Jianbin Wang; Robert Saint; Stephen L Gregory
Journal:  Cell Cycle       Date:  2013-12-12       Impact factor: 4.534

Review 3.  Mitosis as an anti-cancer drug target.

Authors:  Anna-Leena Salmela; Marko J Kallio
Journal:  Chromosoma       Date:  2013-06-18       Impact factor: 4.316

4.  Disruption of CDK-resistant chromatin association by pRB causes DNA damage, mitotic errors, and reduces Condensin II recruitment.

Authors:  Charles A Ishak; Courtney H Coschi; Michael V Roes; Frederick A Dick
Journal:  Cell Cycle       Date:  2017-07-19       Impact factor: 4.534

5.  Whole chromosome gain does not in itself confer cancer-like chromosomal instability.

Authors:  Anders Valind; Yuesheng Jin; Bo Baldetorp; David Gisselsson
Journal:  Proc Natl Acad Sci U S A       Date:  2013-12-09       Impact factor: 11.205

Review 6.  Drosophila melanogaster: a model and a tool to investigate malignancy and identify new therapeutics.

Authors:  Cayetano Gonzalez
Journal:  Nat Rev Cancer       Date:  2013-02-07       Impact factor: 60.716

7.  Cyclin B2 and p53 control proper timing of centrosome separation.

Authors:  Hyun-Ja Nam; Jan M van Deursen
Journal:  Nat Cell Biol       Date:  2014-04-28       Impact factor: 28.824

8.  CDK11(p58) kinase activity is required to protect sister chromatid cohesion at centromeres in mitosis.

Authors:  Tarik Rakkaa; Christophe Escudé; Régis Giet; Laura Magnaghi-Jaulin; Christian Jaulin
Journal:  Chromosome Res       Date:  2014-01-17       Impact factor: 5.239

9.  ANCHR mediates Aurora-B-dependent abscission checkpoint control through retention of VPS4.

Authors:  Sigrid B Thoresen; Coen Campsteijn; Marina Vietri; Kay O Schink; Knut Liestøl; Jens S Andersen; Camilla Raiborg; Harald Stenmark
Journal:  Nat Cell Biol       Date:  2014-05-11       Impact factor: 28.824

10.  The autoregulated instability of Polo-like kinase 4 limits centrosome duplication to once per cell cycle.

Authors:  Andrew J Holland; Daniele Fachinetti; Quan Zhu; Manuel Bauer; Inder M Verma; Erich A Nigg; Don W Cleveland
Journal:  Genes Dev       Date:  2012-12-15       Impact factor: 11.361
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.