| Literature DB >> 33670784 |
Imran Khan1,2, Jing Peng1,2, Zhuangjie Fang1,2, Wei Liu1,3, Wenjun Zhang1,2,3,4, Qingbo Zhang1,3,4, Liang Ma1,3, Guangtao Zhang1,3,4, Changsheng Zhang1,2,3,4, Haibo Zhang1,3,4.
Abstract
The fungus strain SCSIO 40433 was isolated from an Arctic-derived glacier sediment sample and characterized as Tolypocladium cylindrosporum. A new compound, cylindromicin (1), and seven known secondary metabolites (2-8) were isolated from this strain. The chemical structures of these compounds were elucidated by comprehensive spectroscopic analyses. Cylindromicin (1) featured a 3,4-dihydro-2H-pyran skeleton. The absolute configuration of compound 1 was assigned via interpretation of key Nuclear Overhauser Effect Spectroscopy (NOESY) correlations and Electronic Circular Dichroism (ECD) calculation. Cylindromicin (1) exhibited significant tyrosinase inhibition activity. This study highlights Polar fungi as a potential resource for new bioactive natural products.Entities:
Keywords: Arctic; cylindromicin; fungi; tyrosinase
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Year: 2021 PMID： 33670784 PMCID： PMC7922244 DOI： 10.3390/molecules26041080
Source DB: PubMed Journal: Molecules ISSN： 1420-3049 Impact factor: 4.411