Literature DB >> 33669637

Antimicrobial Metabolites against Methicillin-Resistant Staphylococcus aureus from the Endophytic Fungus Neofusicoccum australe.

Melissa M Cadelis1,2, Soeren Geese2, Benedict B Uy2, Daniel R Mulholland2, Shara J van de Pas2, Alex Grey2, Bevan S Weir3, Brent R Copp1, Siouxsie Wiles2.   

Abstract

Antimicrobial bioassay-guided fractionation of the endophytic fungi Neofusicoccum australe led to the isolation of a new unsymmetrical naphthoquinone dimer, neofusnaphthoquinone B (1), along with four known natural products (2-5). Structure elucidation was conducted by nuclear magnetic resonance (NMR) spectroscopic methods, and the antimicrobial activity of all the natural products was investigated, revealing 1 to be moderately active towards methicillin-resistant Staphylococcus aureus (MRSA) with a minimum inhibitory concentration (MIC) of 16 µg/mL.

Entities:  

Keywords:  MRSA; antimicrobial; fungi; naphthoquinone dimer; natural product

Mesh：

Substances：

Year:  2021        PMID： 33669637      PMCID： PMC7922810          DOI： 10.3390/molecules26041094

Source DB:  PubMed          Journal:  Molecules        ISSN： 1420-3049            Impact factor:   4.411


  9 in total

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Journal:  J Antimicrob Chemother       Date:  2001-07       Impact factor: 5.790

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Journal:  Nature       Date:  2014-05-29       Impact factor: 49.962

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Authors:  Gerard D Wright
Journal:  ACS Infect Dis       Date:  2015-01-15       Impact factor: 5.084

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Authors:  Hui Cui; Hongao Zhang; Yena Liu; Qiong Gu; Jun Xu; Xishan Huang; Zhigang She
Journal:  Fitoterapia       Date:  2018-01-31       Impact factor: 2.882

6.  Spermine Derivatives of Indole-3-carboxylic Acid, Indole-3-acetic Acid and Indole-3-acrylic Acid as Gram-Negative Antibiotic Adjuvants.

Authors:  Melissa M Cadelis; Steven A Li; Marie-Lise Bourguet-Kondracki; Marine Blanchet; Hana Douafer; Jean Michel Brunel; Brent R Copp
Journal:  ChemMedChem       Date:  2020-10-30       Impact factor: 3.466

7.  Antimycobacterial substances from Phaeosphaeria sp BCC8292.

Authors:  Pattama Pittayakhajonwut; Pairoh Sohsomboon; Aibrohim Dramae; Rapheephat Suvannakad; Sanisa Lapanun; Morakot Tantichareon
Journal:  Planta Med       Date:  2008-02       Impact factor: 3.352

8.  New bioactive metabolites from a freshwater isolate of the fungus Kirschsteiniothelia sp.

Authors:  G K Poch; J B Gloer; C A Shearer
Journal:  J Nat Prod       Date:  1992-08       Impact factor: 4.050

9.  A Revised Structure and Assigned Absolute Configuration of Theissenolactone A.

Authors:  Melissa M Cadelis; Soeren Geese; Lauren Gris; Bevan S Weir; Brent R Copp; Siouxsie Wiles
Journal:  Molecules       Date:  2020-10-20       Impact factor: 4.411
  9 in total

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