Literature DB >> 27622818

Helping Chemists Discover New Antibiotics.

Mark A T Blaskovich1, Johannes Zuegg1, Alysha G Elliott1, Matthew A Cooper1.   

Abstract

The world is facing a crisis in treating infectious diseases, with a scarcity of new antibiotics in development to treat the growing threat of drug-resistant "superbugs". We need new strategies to reinvigorate the antibiotic pipeline. In this Viewpoint we discuss one such approach, encouraging the community of synthetic chemists to participate in testing chemical diversity from their laboratories for antimicrobial potential. CO-ADD, the Community for Open Antimicrobial Drug Discovery, offers free screening against five bacteria and two fungi with follow up hit confirmation and validation, all with no strings attached.

Entities:  

Year:  2015        PMID: 27622818     DOI: 10.1021/acsinfecdis.5b00044

Source DB:  PubMed          Journal:  ACS Infect Dis        ISSN: 2373-8227            Impact factor:   5.084


  37 in total

Review 1.  Antibiotics in the clinical pipeline at the end of 2015.

Authors:  Mark S Butler; Mark At Blaskovich; Matthew A Cooper
Journal:  J Antibiot (Tokyo)       Date:  2016-06-29       Impact factor: 2.649

2.  Endless Resistance. Endless Antibiotics?

Authors:  Jed F Fisher; Shahriar Mobashery
Journal:  Medchemcomm       Date:  2015-11-03       Impact factor: 3.597

Review 3.  Instructive Advances in Chemical Microbiology Inspired by Nature's Diverse Inventory of Molecules.

Authors:  Ke Liu; Robert W Huigens
Journal:  ACS Infect Dis       Date:  2020-01-06       Impact factor: 5.084

4.  Norbornane-based cationic antimicrobial peptidomimetics targeting the bacterial membrane.

Authors:  Shane M Hickey; Trent D Ashton; Gareth Boer; Christie A Bader; Michael Thomas; Alysha G Elliott; Carsten Schmuck; Heidi Y Yu; Jian Li; Roger L Nation; Matthew A Cooper; Sally E Plush; Douglas A Brooks; Frederick M Pfeffer
Journal:  Eur J Med Chem       Date:  2018-10-03       Impact factor: 6.514

Review 5.  Strategic Moves of "Superbugs" Against Available Chemical Scaffolds: Signaling, Regulation, and Challenges.

Authors:  Bikash Baral; M R Mozafari
Journal:  ACS Pharmacol Transl Sci       Date:  2020-04-13

6.  Harnessing the toxicity of dysregulated iron uptake for killing Staphylococcus aureus: reality or mirage?

Authors:  Nalin Abeydeera; Bing Yu; Bishnu D Pant; Min-Ho Kim; Songping D Huang
Journal:  Biomater Sci       Date:  2022-01-18       Impact factor: 6.843

7.  Antitubercular and Antiparasitic 2-Nitroimidazopyrazinones with Improved Potency and Solubility.

Authors:  Chee Wei Ang; Lendl Tan; Melissa L Sykes; Neda AbuGharbiyeh; Anjan Debnath; Janet C Reid; Nicholas P West; Vicky M Avery; Matthew A Cooper; Mark A T Blaskovich
Journal:  J Med Chem       Date:  2020-11-05       Impact factor: 7.446

8.  Taming Amphotericin B.

Authors:  Vaclav Janout; Wiley A Schell; Damien Thévenin; Yuming Yu; John R Perfect; Steven L Regen
Journal:  Bioconjug Chem       Date:  2015-09-10       Impact factor: 4.774

9.  Positional Isomers of Biphenyl Antimicrobial Peptidomimetic Amphiphiles.

Authors:  Andrew J Tague; Papanin Putsathit; Thomas V Riley; Paul A Keller; Stephen G Pyne
Journal:  ACS Med Chem Lett       Date:  2021-02-03       Impact factor: 4.345

10.  Isolation of a Novel Polyketide from Neodidymelliopsis sp.

Authors:  Melissa M Cadelis; Hugo Gordon; Alex Grey; Soeren Geese; Daniel R Mulholland; Bevan S Weir; Brent R Copp; Siouxsie Wiles
Journal:  Molecules       Date:  2021-05-27       Impact factor: 4.411

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