Zhi-Cong Wang1, Wei Jiang1, Xi Chen1, Ling Yang1, Hong Wang1, Yue-Hong Liu2. 1. Orthopaedic Center of Deyang City, Department of Orthopedics, People's Hospital of Deyang City, Deyang City, 618000, Sichuan, China. 2. Orthopaedic Center of Deyang City, Department of Orthopedics, People's Hospital of Deyang City, Deyang City, 618000, Sichuan, China. doctorliuyuehong@163.com.
Abstract
BACKGROUND: The systemic immune-inflammation index (SII), based on peripheral platelet, neutrophil and lymphocyte counts, has been proven to be a promising prognostic indicator in various diseases. Hip fracture is a common injury among the older adults, and has become a global public health problem with high mortality and disability rates. However, the relationship between SII and the prognosis of hip fracture is not yet well-known. The aim of the this study was to explore the predictive value of SII in older adults with hip fracture undergoing surgery. METHODS: This was a prospective cohort study performed from January 2014 to December 2018 at a orthopaedic center, China. The SII was calculated as platelet×neutrophil/lymphocyte counts. Univariable and multivariable Cox proportional hazard models were used to assess the association between SII and all-cause mortality. RESULTS: A total of 290 older adults with hip fracture were included, and the mean (SD) age was 77.6 (8.6) years, and 189 (65.2%) were female. The median (IQR) SII was 759.4 (519.0-1128.7) × 109/L. After a median follow-up time of 33.4 months, 13 (4.5%), 26 (9.0%) and 54 (18.6%) patients died within the 30-day, 1-year and last follow-up, respectively. Multivariable Cox analysis revealed that each increase of 100 units of SII was associated with a 8% increased hazard of death at 1-year follow-up (HR = 1.08, 95% CI: 1.01-1.17, p = 0.033), and 9% increased hazard of death at last follow-up (HR = 1.09, 95% CI: 1.03-1.15, p = 0.003). CONCLUSIONS: SII is associated with poor all-cause mortality in older adults with hip fracture undergoing surgery, and deserves further investigation and application in clinical practice.
BACKGROUND: The systemic immune-inflammation index (SII), based on peripheral platelet, neutrophil and lymphocyte counts, has been proven to be a promising prognostic indicator in various diseases. Hip fracture is a common injury among the older adults, and has become a global public health problem with high mortality and disability rates. However, the relationship between SII and the prognosis of hip fracture is not yet well-known. The aim of the this study was to explore the predictive value of SII in older adults with hip fracture undergoing surgery. METHODS: This was a prospective cohort study performed from January 2014 to December 2018 at a orthopaedic center, China. The SII was calculated as platelet×neutrophil/lymphocyte counts. Univariable and multivariable Cox proportional hazard models were used to assess the association between SII and all-cause mortality. RESULTS: A total of 290 older adults with hip fracture were included, and the mean (SD) age was 77.6 (8.6) years, and 189 (65.2%) were female. The median (IQR) SII was 759.4 (519.0-1128.7) × 109/L. After a median follow-up time of 33.4 months, 13 (4.5%), 26 (9.0%) and 54 (18.6%) patientsdied within the 30-day, 1-year and last follow-up, respectively. Multivariable Cox analysis revealed that each increase of 100 units of SII was associated with a 8% increased hazard of death at 1-year follow-up (HR = 1.08, 95% CI: 1.01-1.17, p = 0.033), and 9% increased hazard of death at last follow-up (HR = 1.09, 95% CI: 1.03-1.15, p = 0.003). CONCLUSIONS: SII is associated with poor all-cause mortality in older adults with hip fracture undergoing surgery, and deserves further investigation and application in clinical practice.
Entities:
Keywords:
Hip fracture; Mortality; Older adults; Prognosis; Systemic immune-inflammation index
Authors: Eu-Leong Yong; Ganga Ganesan; Michael S Kramer; Tet Sen Howe; Joyce S B Koh; Win Pa Thu; Susan Logan; Jane A Cauley; Kelvin B Tan Journal: JAMA Netw Open Date: 2020-02-05
Authors: William J Doherty; Thomas A Stubbs; Andrew Chaplin; Mike R Reed; Avan A Sayer; Miles D Witham; Antony K Sorial Journal: J Am Med Dir Assoc Date: 2020-09-04 Impact factor: 4.669