Amare Abera Tareke1, Addis Alem Hadgu2. 1. Physiology Unit, Department of Biomedical Sciences, College of Medicine and Health Sciences, Wollo University, Dessie, Ethiopia. amareabera8@gmail.com. 2. Biochemistry Unit, Department of Biomedical Sciences, College of Medicine and Health Sciences, Wollo University, Dessie, Ethiopia.
Abstract
BACKGROUND AND AIMS: We conducted a systematic review and meta-analysis of clinical trials evaluating the role of vitamin C supplementation on lipid profiles among diabetic patients to summarize the available findings. METHODS: A comprehensive search of PubMed, ScienceDirect, Google Scholar, and Cochrane Library databases was performed. Clinical trials conducted on adult type 2 diabetic patients evaluating the effect of vitamin C supplementation and reported lipid profiles (cholesterol (TC), triglycerides (TG), low density lipoprotein (LDL), high density lipoprotein (HDL)) were included. Weighted mean difference (WMD) was calculated. RESULTS: Vitamin C supplementation had no significant effect on TC (WMD = - 4.36 mg/dl (95% CI - 10.24, 1.52) p-value = 0.146), LDL level (WMD = 2.73 mg/dl (95% CI - 1.72, 7.17) p-value = 0.229), and HDL level (WMD = 0.91 mg/dl (CI - 0.45, 2.27) p-value = 0.191). However, it reduced TG and secondary outcomes (FBS and HgA1C): TG (WMD = - 11.15 mg/dl (95% CI - 21.58, - 0.71) p-value = 0.036), FBS (WMD = - 16.94 mg/dl CI - 21.84, - 12.04, p-value = 0.000), and HgA1C (WMD = - 1.01% CI - 1.18, - 0.83, p-value = 0.001. Subgroup analysis also depicted younger patients, longer duration of treatment and higher dose were important factors. In addition, meta-regression analysis indicated the significant role of patient age, duration of treatment, supplementation dose, BMI and other baseline variables. CONCLUSION: There is no adequate evidence to support vitamin C supplementation for dyslipidemias in diabetic patients. Specific group of patients might have benefited including younger diabetic patients. Future researches should give emphasis on the duration of treatment, the dose of vitamin C and baseline values.
BACKGROUND AND AIMS: We conducted a systematic review and meta-analysis of clinical trials evaluating the role of vitamin C supplementation on lipid profiles among diabeticpatients to summarize the available findings. METHODS: A comprehensive search of PubMed, ScienceDirect, Google Scholar, and Cochrane Library databases was performed. Clinical trials conducted on adult type 2 diabeticpatients evaluating the effect of vitamin C supplementation and reported lipid profiles (cholesterol (TC), triglycerides (TG), low density lipoprotein (LDL), high density lipoprotein (HDL)) were included. Weighted mean difference (WMD) was calculated. RESULTS:Vitamin C supplementation had no significant effect on TC (WMD = - 4.36 mg/dl (95% CI - 10.24, 1.52) p-value = 0.146), LDL level (WMD = 2.73 mg/dl (95% CI - 1.72, 7.17) p-value = 0.229), and HDL level (WMD = 0.91 mg/dl (CI - 0.45, 2.27) p-value = 0.191). However, it reduced TG and secondary outcomes (FBS and HgA1C): TG (WMD = - 11.15 mg/dl (95% CI - 21.58, - 0.71) p-value = 0.036), FBS (WMD = - 16.94 mg/dl CI - 21.84, - 12.04, p-value = 0.000), and HgA1C (WMD = - 1.01% CI - 1.18, - 0.83, p-value = 0.001. Subgroup analysis also depicted younger patients, longer duration of treatment and higher dose were important factors. In addition, meta-regression analysis indicated the significant role of patient age, duration of treatment, supplementation dose, BMI and other baseline variables. CONCLUSION: There is no adequate evidence to support vitamin C supplementation for dyslipidemias in diabeticpatients. Specific group of patients might have benefited including younger diabeticpatients. Future researches should give emphasis on the duration of treatment, the dose of vitamin C and baseline values.
Entities:
Keywords:
Diabetes mellitus; Dyslipidemia; Lipid profiles; Meta-analysis; Vitamin C
Authors: Rudolf P Obermayr; Christian Temml; Maarten Knechtelsdorfer; Georg Gutjahr; Josef Kletzmayr; Susanne Heiss; Anton Ponholzer; Stephan Madersbacher; Rainer Oberbauer; Renate Klauser-Braun Journal: Nephrol Dial Transplant Date: 2007-11-26 Impact factor: 5.992