Severe lumbar spinal stenosis combined with Guillain-Barré syndrome: A case report.

BACKGROUND: Guillain-Barré syndrome (GBS) is a rare disorder that typically presents with ascending weakness, pain, paraesthesias, and numbness, which mimic the findings in lumbar spinal stenosis. Here, we report a case of severe lumbar spinal stenosis combined with GBS. CASE
SUMMARY: A 70-year-old man with a history of lumbar spinal stenosis presented to our emergency department with severe lower back pain and lower extremity numbness. Magnetic resonance imaging confirmed the diagnosis of severe lumbar spinal stenosis. However, his symptoms did not improve postoperatively and he developed dysphagia and upper extremity numbness. An electromyogram was performed. Based on his symptoms, physical examination, and electromyogram, he was diagnosed with GBS. After 5 d of intravenous immunoglobulin (0.4 g/kg/d for 5 d) therapy, he gained 4/5 of strength in his upper and lower extremities and denied paraesthesias. He had regained 5/5 of strength in his extremities when he was discharged and had no symptoms during follow-up.
CONCLUSION: GBS should be considered in the differential diagnosis of spinal disorder, even though magnetic resonance imaging shows severe lumbar spinal stenosis. This case highlights the importance of a careful diagnosis when a patient has a history of a disease and comes to the hospital with the same or similar symptoms. ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.

Core Tip: A 70-year-old man with a history of lumbar spinal stenosis presented to our emergency department because of severe lower back pain and lower extremity numbness. On the physical examination, he had 4/5 of strength in both legs and decreased sensation below the knees. Magnetic resonance imaging demonstrated lumbar spinal stenosis (L4/5). Based on these findings, he was diagnosed with lumbar spinal stenosis. After conservative treatment failed, he underwent transforaminal lumbar interbody fusion. However, his symptoms worsened postoperatively and dysphagia appeared. An electromyogram was performed. Finally, he was diagnosed with Guillain-Barré syndrome. After 5 d of intravenous immunoglobulin therapy, he gained 4/5 of strength in his upper and lower extremities and denied paraesthesias. This case demonstrates that Guillain-Barré syndrome should be considered in the differential diagnosis of spinal disorder and highlights the importance of a careful diagnosis when a patient has a history of a disease and comes to the hospital with the same or similar symptoms.

INTRODUCTION

Lumbar spinal stenosis is common in older people. The spinal canal is constricted by osteophytes, disc degeneration, and the ligamentum flavum, compressing the dural sac, spinal cord, or nerve roots, which leads to low back and leg pain, numbness, lower limb weakness, claudication, etc[1]. Decompression of the spinal canal is an effective treatment for severe lumbar spinal stenosis and the pain, numbness, and walking ability improve postoperatively[1-3].

Guillain-Barré syndrome (GBS) is an autoimmune peripheral neuropathy characterized by demyelination of the peripheral nerves and nerve roots and infiltration of inflammatory cells in small blood vessels[4-6]. It is rare, with an incidence is 1 to 2 per 100000 per year worldwide[7]. The typical symptoms of GBS are ascending weakness, pain, paraesthesia, and numbness, which are also those of lumbar spinal stenosis. Since GBS is rare, patients might be misdiagnosed and subsequently receive the wrong treatment, especially patients with a history of lumbar spinal stenosis.

Here, we present a 70-year-old man who had severe lower back pain and lower extremity numbness. Magnetic resonance imaging (MRI) confirmed the diagnosis of severe lumbar spinal stenosis. However, his symptoms did not improve postoper-atively. An electromyogram was performed. Based on his symptoms, physical examination, and electromyogram, he was diagnosed with GBS and subsequently treated correctly. This case highlights that GBS should be considered in the differential diagnosis of spinal diseases.

CASE PRESENTATION

Chief complaints

Lower back pain and lower extremity numbness for 10 h.

History of present illness

A 70-year-old man with a history of lumbar spinal stenosis, hypertension, and gout presented to our emergency department because of severe lower back pain and lower extremity numbness. He has been receiving intermittent physical therapy and medical treatment for lower back pain and lower extremity numbness. On the physical examination, he had tenderness in the lower back, and no obvious decrease in skin sensation around the anus. He had 4/5 of strength in both legs and decreased sensation below the knees. Lasègue signs were negative. The bilateral knee and Achilles tendon reflexes were normal. He had joint deformity and gout nodules between the fingers and toes. Babinski’s sign and other pathological reflex signs were negative. Laboratory testing was largely unremarkable, aside from a uric acid level of 462 μmol/L. X-rays showed degenerative changes of the lumbar spine and the L4 vertebral body had slipped forward slightly. He was diagnosed with spinal stenosis by an orthopedic surgeon and admitted to the Department of Spinal Surgery for further workup.

After admission, he was treated with steroid injections, analgesia, and nervous system nutrients for symptom relief. MRI demonstrated lumbar spinal stenosis (L4/5). Based on these findings, he was diagnosed with lumbar spinal stenosis. After conservative treatment failed, he underwent transforaminal lumbar interbody fusion. Postoperatively, his paraesthesias and muscle weakness did not improve markedly and he reported numbness and weakness in both upper extremities. On postoperative day 2, he had 2/5 of strength in his upper extremities and 1/5 of strength in his lower extremities. Deep tendon reflexes (for example triceps reflex, biceps reflex, and knee and Achilles tendon reflexes) disappeared. He also reported dysphagia and numbness in the upper extremities. We requested a neurology consultation. Careful review of the patient’s history, as provided by his family and community doctor, revealed that he got the flu vaccination 10 d ago.

An electromyogram was obtained, but no lumbar puncture was performed because of his recent surgery. The electrophysiological study showed reduced motor and sensory responses in his extremities. Given his symptoms, physical examination, and laboratory tests, he was diagnosed with GBS (the form is acute inflammatory demyelinating polyneuropathy). Intravenous immunoglobulin (IVIG) was started (0.4 g/kg/day for 5 d)[6,8]. He reported some improvement during therapy. He gained 4/5 of strength in his upper and lower extremities and denied paraesthesias after 5 d of therapy. Then, he was given ultrasound therapy, electroacupuncture, and electronic biofeedback therapy and postoperative rehabilitation. He regained 5/5 of strength in his extremities and could ambulate without aid after about 4 wk, when he was discharged. At the follow-up, he was asymptomatic.

History of past illness

The patient had a history of hypertension for nearly 20 years, but the blood pressure is normal after taking valsartan capsule (80 mg per day). He also had a history of gout for 15 years, and was receiving the oral administration of febuxostat (40 mg per day).

Personal and family history

The patient worked as a farmer. He neither smokes nor drinks. He got the flu vaccina-tion 10 d ago.

Physical examination

He had tenderness in the lower back, and no obvious decrease in skin sensation around the anus. He had 4/5 of strength in both legs and decreased sensation below the knees. Lasègue signs were negative. The bilateral knee and Achilles tendon reflexes were normal. He had joint deformity and gout nodules between the fingers and toes. Babinski’s sign and other pathological reflex signs were negative.

Laboratory examinations

The uric acid level was 462 μmol/L.

Imaging examinations

X-rays (Figure 1) showed degenerative changes of the lumbar spine and the L4 vertebral body had slipped forward slightly. MRI (Figure 2) demonstrated lumbar spinal stenosis (L4/5). The results of electromyogram are listed in Table 1.

Figure 1

X-rays showed degenerative changes of the lumbar spine and the L4 vertebral body had slipped forward slightly. Preoperative anterior-posterior (A) and lateral (B) radiographs of the spine demonstrating degenerative changes of the lumbar spine and that the L4 vertebral body had slipped forward slightly. Postoperative anterior-posterior (C) and lateral (D) radiographs of the spine demonstrating the L4-5 instrumented fusion with bilateral segmental pedicle screws-rods fixation and interbody cage devices.

Figure 2

Sagittal view of T2 weighted magnetic resonance imaging. The arrow shows severe canal stenosis at L4/5.

Table 1

The results of nerve conduction examination

Nerve	Conduction	NCV (m/s)		Stimulating points	Record points	Incubation period (ms)		CMAP (mv) or SNAP (μv)
		Left	Right			Left	Right	Left	Right
Median nerve (S)			38.8	Middle finger	Wrist	No	3.3		1.2
Ulnar nerve (S)			33.7	Little finger	Wrist	No	3.0		1.0
Median nerve (M)	Wrist to elbow		25.2		Abductor pollicis brevis	No	5.8		0.6
Ulnar nerve (M)	Wrist to elbow	32.9	33.7		Abductor digiti minimi	3.2	3.6	0.7	0.8
Common peroneal nerve (M)	Ankle to capitula fibula	26.7	17.8		Extensor digitorum brevis	5.1	4.4	0.5	0.3
Superficial peroneal nerve (S)				Middle fibula	Ankle	No	No
Tibial nerve (M)	Malleolus medialis to popliteal space	27.6	28.5		Flexor hallucis brevis	5.2	5.9	0.3	0.4
Sural nerve (S)					Lateral malleolus	No	No

The sensory nerve action potentials of the bilateral superficial peroneal nerve, bilateral sural nerve, left median nerve, and left ulnar nerve were not elicited, the sensory nerve conduction velocity of the right median nerve and ulnar nerve slowed down, and the sensory nerve action potential amplitude decreased. The left median nerve compound motor action potential was not elicited, the right median nerve, bilateral common peroneal nerve, bilateral ulnar nerve, bilateral tibial nerve motor nerve conduction velocity slowed down, and compound motor action potential amplitude decreased, with a discrete waveform. These findings demonstrated multiple peripheral nerve damage. S: Sensory; M: Motor; NCV: Nerve conduction examination; CMAP: Compound motor action potential; SNAP: Sensory nerve action potential.

FINAL DIAGNOSIS

The patient was diagnosed with Guillain-Barré syndrome, and the form is acute inflammatory demyelinating polyneuropathy.

TREATMENT

The patient was started on intravenous immunoglobulin (0.4 g/kg/day for 5 d). Then, he was given ultrasound therapy, electroacupuncture, and electronic biofeedback therapy and postoperative rehabilitation.

OUTCOME AND FOLLOW-UP

He gained 4/5 of strength in his upper and lower extremities and denied paraesthesias after 5 d of intravenous immunoglobulin therapy. He regained 5/5 of strength in his extremities and could ambulate without aid after about 4 wk, when he was dis-charged. At the follow-up, he was asymptomatic.

DISCUSSION

We present a patient with a history of lumbar spinal stenosis who suffered severe pain in the lower back and lower extremity numbness. Based on his medical history, symptoms, physical examination, and MRI results, he was diagnosed with lumbar spinal stenosis and underwent surgical treatment. However, his symptoms worsened postoperatively and dysphagia appeared. He was diagnosed with GBS by a neurologist after electromyography. After 5 d of IVIG therapy, his symptoms improved.

GBS is a rare disorder and the typical symptoms are ascending weakness, pain, paraesthesias, and numbness, which are similar to those of a spinal disorder. This makes it difficult for most spinal surgeons to diagnose. Our patient had a history of lumbar spinal stenosis, with lower back pain and lower extremity numbness, which improved after medication. This time he was admitted because his symptoms were worsening. After admission, MRI showed severe lumbar spinal stenosis (L4/5), consistent with the clinical findings. We unanimously believed that he was showing progression of his original disease, which caused the misdiagnosis. Careful review of the patient’s history and physical examination showed that his muscle strength in the lower extremities was symmetrical. After several days of conservative treatment including steroid injections, his symptoms did not improve markedly. This is atypical of lumbar spinal stenosis. Patients with lumbar spinal stenosis have numbness and weakness in the lower extremities, but they are not always symmetrical and their symptoms will improve after conservative treatment, especially steroid injections[1,3,9]. By contrast, steroid injections are not beneficial in the management of GBS[6,10]. When we consider only the initial findings, the diagnosis is challenging. This case demonstrates that GBS should be considered in the differential diagnosis of spinal disorder.

The diagnosis of GBS is usually confirmed by electromyography and lumbar puncture[5,6,8]. Because our patient had had lumbar spine surgery, lumbar puncture was inappropriate. We obtained an electromyogram and, with the help of a neurologist, obtained the correct diagnosis, enabling prompt treatment.

There have been several recent reports of GBS after spinal surgery. Rashid et al[11] reported a 62-year-old woman who underwent lumbar spine surgery revision and developed leg weakness and respiratory failure approximately 2 wk postoperatively. After an electromyogram, she was diagnosed with GBS and placed on IVIG. Abode-Iyamah et al[12] present a case of GBS after lumbar spine surgery. Postoperatively, their patient’s symptoms of paraesthesia, pain, and weakness relieved markedly. However, on postoperative day 5, she reported weakness that worsened progressively. Finally, she was diagnosed with GBS after MRI and lumbar puncture. Chen et al[13] described a patient who showed characteristics of GBS on postoperative day 9. GBS was a postoperative spinal complication in these reports[14]. Our report differs from these cases in that our patient’s symptoms of numbness and lower extremity weakness worsened progressively postoperatively and he also developed dysphagia and upper extremity numbness. These are not typical postoperative spinal complications[1,15]. We made a mistake in the diagnosis, and the spinal surgery was inappropriate.

GBS is an immune-mediated disorder. Infection and vaccination have been considered to be associated with its occurrence. The patient denied any respiratory infection or gastroenteritis recently, but he was found to get the flu vaccination by carefully reviewing his history. Cases of GBS have been reported after vaccination[16]. The vaccination might be the etiology of our patient. After vaccination, an autoimmune response is initiated, and antibodies that attack myelin protein are produced, leading to demyelination and axonal damage. The operation has been thought to alter the balance of the immune system and accelerate the progression of his original disease[17,18].

CONCLUSION

A patient with a history of lumbar spinal stenosis developed pain in the lower back and lower extremity numbness. Although MRI showed severe lumbar spinal stenosis, we must still consider other spinal or neurological diseases, including GBS. When a patient has a history of one disease that is not responding to conventional therapy, other illnesses with similar symptoms should be considered carefully and invest-igated.