Literature DB >> 33626142

Whole-body metabolic fate of branched-chain amino acids.

Megan C Blair1, Michael D Neinast2, Zoltan Arany1.   

Abstract

Oxidation of branched-chain amino acids (BCAAs) is tightly regulated in mammals. We review here the distribution and regulation of whole-body BCAA oxidation. Phosphorylation and dephosphorylation of the rate-limiting enzyme, branched-chain α-ketoacid dehydrogenase complex directly regulates BCAA oxidation, and various other indirect mechanisms of regulation also exist. Most tissues throughout the body are capable of BCAA oxidation, and the flux of oxidative BCAA disposal in each tissue is influenced by three key factors: 1. tissue-specific preference for BCAA oxidation relative to other fuels, 2. the overall oxidative activity of mitochondria within a tissue, and 3. total tissue mass. Perturbations in BCAA oxidation have been implicated in many disease contexts, underscoring the importance of BCAA homeostasis in overall health.
© 2021 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society.

Entities:  

Keywords:  branched chain amino acids; isoleucine; leucine; organismal metabolism; valine

Mesh：

Substances：

Year:  2021        PMID： 33626142      PMCID： PMC9183206          DOI： 10.1042/BCJ20200686

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.766


  115 in total

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