Literature DB >> 22560213

Interplay between lipids and branched-chain amino acids in development of insulin resistance.

Christopher B Newgard1.   

Abstract

Fatty acids (FA) and FA-derived metabolites have long been implicated in the development of insulin resistance and type 2 diabetes. Surprisingly, application of metabolomics technologies has revealed that branched-chain amino acids (BCAA) and related metabolites are more strongly associated with insulin resistance than many common lipid species. Moreover, the BCAA-related signature is predictive of incident diabetes and intervention outcomes and uniquely responsive to therapeutic interventions. Nevertheless, in animal feeding studies, BCAA supplementation requires the background of a high-fat diet to promote insulin resistance. This Perspective develops a model to explain how lipids and BCAA may synergize to promote metabolic diseases.
Copyright © 2012 Elsevier Inc. All rights reserved.

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Year:  2012        PMID： 22560213      PMCID： PMC3695706          DOI： 10.1016/j.cmet.2012.01.024

Source DB:  PubMed          Journal:  Cell Metab        ISSN： 1550-4131            Impact factor:   27.287


  55 in total

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