| Literature DB >> 27346343 |
Luigi Fontana1, Nicole E Cummings2, Sebastian I Arriola Apelo3, Joshua C Neuman4, Ildiko Kasza5, Brian A Schmidt3, Edda Cava6, Francesco Spelta7, Valeria Tosti7, Faizan A Syed3, Emma L Baar3, Nicola Veronese8, Sara E Cottrell9, Rachel J Fenske4, Beatrice Bertozzi10, Harpreet K Brar3, Terri Pietka10, Arnold D Bullock11, Robert S Figenshau11, Gerald L Andriole11, Matthew J Merrins12, Caroline M Alexander5, Michelle E Kimple13, Dudley W Lamming14.
Abstract
Protein-restricted (PR), high-carbohydrate diets improve metabolic health in rodents, yet the precise dietary components that are responsible for these effects have not been identified. Furthermore, the applicability of these studies to humans is unclear. Here, we demonstrate in a randomized controlled trial that a moderate PR diet also improves markers of metabolic health in humans. Intriguingly, we find that feeding mice a diet specifically reduced in branched-chain amino acids (BCAAs) is sufficient to improve glucose tolerance and body composition equivalently to a PR diet via metabolically distinct pathways. Our results highlight a critical role for dietary quality at the level of amino acids in the maintenance of metabolic health and suggest that diets specifically reduced in BCAAs, or pharmacological interventions in this pathway, may offer a translatable way to achieve many of the metabolic benefits of a PR diet.Entities:
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Year: 2016 PMID： 27346343 PMCID： PMC4947548 DOI： 10.1016/j.celrep.2016.05.092
Source DB: PubMed Journal: Cell Rep Impact factor: 9.423