Jachym Rosendorf1,2, Marketa Klicova3, Lenka Cervenkova2,4, Richard Palek5,2, Jana Horakova3, Andrea Klapstova3, Petr Hosek2, Vladimira Moulisova2, Lukas Bednar2, Vaclav Tegl2,6, Ondrej Brzon2, Zbynek Tonar2,7, Vladislav Treska5, David Lukas3,8, Vaclav Liska5,2. 1. Department of Surgery, Faculty of Medicine in Pilsen, Charles University, Prague, Czech Republic; jachymrosendorf@gmail.com. 2. Biomedical Center, Faculty of Medicine in Pilsen, Charles University, Prague, Czech Republic. 3. Department of Nonwovens and Nanofibrous Materials, Faculty of Textile Engineering, Technical University of Liberec, Liberec, Czech Republic. 4. Department of Pathology, Third Faculty of Medicine, Charles University, Prague, Czech Republic. 5. Department of Surgery, Faculty of Medicine in Pilsen, Charles University, Prague, Czech Republic. 6. Department of Anesthesiology and Intensive Care Medicine, Faculty of Medicine in Plzen, Pilsen, Czech Republic. 7. Department of Histology and Embryology, Faculty of Medicine in Pilsen, Charles University, Prague, Czech Republic. 8. Department of Chemistry, Faculty of Science, Humanities and Education, Technical University of Liberec, Liberec, Czech Republic.
Abstract
BACKGROUND/AIM: Anastomotic leakage is a feared complication in colorectal surgery. Postoperative peritoneal adhesions can also cause life-threatening conditions. Nanofibrous materials showed their pro-healing properties in various studies. The aim of the study was to evaluate the impact of double-layered nanofibrous materials on anastomotic healing and peritoneal adhesions formation. MATERIALS AND METHODS: Two versions of double-layered materials from polycaprolactone and polyvinyl alcohol were applied on defective anastomosis on the small intestine of healthy pigs. The control group remained with uncovered defect. Tissue specimens were subjected to histological analysis and adhesion scoring after 3 weeks of observation. RESULTS: The wound healing was inferior in the experimental groups, however, no anastomotic leakage was observed and the applied material always kept covering the defect. The extent of adhesions was larger in the experimental groups. CONCLUSION: Nanofibrous materials may prevent anastomotic leakage but delay healing. Copyright
BACKGROUND/AIM: Anastomotic leakage is a feared complication in colorectal surgery. Postoperative peritoneal adhesions can also cause life-threatening conditions. Nanofibrous materials showed their pro-healing properties in various studies. The aim of the study was to evaluate the impact of double-layered nanofibrous materials on anastomotic healing and peritoneal adhesions formation. MATERIALS AND METHODS: Two versions of double-layered materials from polycaprolactone and polyvinyl alcohol were applied on defective anastomosis on the small intestine of healthy pigs. The control group remained with uncovered defect. Tissue specimens were subjected to histological analysis and adhesion scoring after 3 weeks of observation. RESULTS: The wound healing was inferior in the experimental groups, however, no anastomotic leakage was observed and the applied material always kept covering the defect. The extent of adhesions was larger in the experimental groups. CONCLUSION: Nanofibrous materials may prevent anastomotic leakage but delay healing. Copyright
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