| Literature DB >> 33605423 |
Linlin Bao1,2, Zhiqi Song1,2, Jing Xue1,2, Hong Gao1,2, Jiangning Liu1,2, Jie Wang1,2, Qian Guo2, Binbin Zhao1,2, Yajin Qu1,2, Feifei Qi1,2, Shuran Gong1,2, Mingya Liu1,2, Qi Lv1,2, Dan Li1,2, Yunlin Han1,2, Wenjie Zhao1,2, Shoulong Deng2, Yunpeng Liu2, Zhiguang Xiang2, Bochao Yang2, Wei Deng1,2, Haisheng Yu1,2, Zhe Cong1,2, Qiang Wei1,2, Jianguo Xu3, George F Gao4, Chuan Qin1,2.
Abstract
Domestic cats, an important companion animal, can be infected with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). This has aroused concern regarding the ability of domestic cats to spread the virus that causes coronavirus disease 2019. We systematically demonstrated the pathogenesis and transmissibility of SARS-CoV-2 in cats. Serial passaging of the virus between cats dramatically attenuated the viral transmissibility, likely owing to variations of the amino acids in the receptor-binding domain sites of angiotensin-converting enzyme 2 between humans and cats. These findings provide insight into the transmissibility of SARS-CoV-2 in cats and information for protecting the health of humans and cats.Entities:
Keywords: COVID-19; SARS-CoV-2; cats; pathogenesis; susceptibility; transmissibility
Year: 2021 PMID： 33605423 PMCID： PMC7928776 DOI： 10.1093/infdis/jiab104
Source DB: PubMed Journal: J Infect Dis ISSN： 0022-1899 Impact factor: 5.226