| Literature DB >> 33584324 |
Md Sahab Uddin1,2, Md Motiar Rahman3, Mohammad Abu Sufian1,2, Philippe Jeandet4, Ghulam Md Ashraf5,6, May N Bin-Jumah7, Shaker A Mousa8, Mohamed M Abdel-Daim9,10, Muhammad Furqan Akhtar11, Ammara Saleem12, Md Shah Amran13.
Abstract
Alzheimer's disease (AD) is the most common form of dementia, which causes abnormalities in learning, thinking, memory, as well as behavior. Generally, symptoms of AD develop gradually and aggravate over time, and consequently severely interfere with daily activities. Furthermore, obesity is one of the common risk factors for dementia. Dysregulation of adipokine and adipocyte dysfunction are assumed to be accountable for the high risk of obesity in people that develop many related disorders such as AD. Moreover, it has been observed that the dysfunction of adipose is connected with changes in brain metabolism, brain atrophy, cognitive decline, impaired mood, neuroinflammation, impaired insulin signaling, and neuronal dysfunction in people with obesity. Conversely, the pathological mechanisms, as well as the molecular players which are involved in this association, have been unclear until now. In this article, we discuss the impact of adiponectin (AdipoQ) on obesity-related Alzheimer's dementia.Entities:
Keywords: AdipoQ; Alzheimer’s disease; adipocyte dysfunction; adipokine; obesity
Year: 2021 PMID： 33584324 PMCID： PMC7873563 DOI： 10.3389/fphys.2020.567678
Source DB: PubMed Journal: Front Physiol ISSN： 1664-042X Impact factor: 4.566