Remote Continuous Glucose Monitoring With a Computerized Insulin Infusion Protocol for Critically Ill Patients in a COVID-19 Medical ICU: Proof of Concept.

OBJECTIVE: The use of remote real-time continuous glucose monitoring (CGM) in the hospital has rapidly emerged to preserve personal protective equipment and reduce potential exposures during coronavirus disease 2019 (COVID-19). RESEARCH DESIGN AND METHODS: We linked a hybrid CGM and point-of-care (POC) glucose testing protocol to a computerized decision support system for continuous insulin infusion and integrated a validation system for sensor glucose values into the electronic health record. We report our proof-of-concept experience in a COVID-19 intensive care unit.
RESULTS: All nine patients required mechanical ventilation and corticosteroids. During the protocol, 75.7% of sensor values were within 20% of the reference POC glucose with an associated average reduction in POC of 63%. Mean time in range (70-180 mg/dL) was 71.4 ± 13.9%. Sensor accuracy was impacted by mechanical interferences in four patients.
CONCLUSIONS: A hybrid protocol integrating real-time CGM and POC is helpful for managing critically ill patients with COVID-19 requiring insulin infusion.

Introduction

Several studies have confirmed the association of in-hospital hyperglycemia with increased mortality in patients with coronavirus disease 2019 (COVID-19) (1–3). Multiple transformations in inpatient diabetes care are occurring during this pandemic to preserve personal protective equipment (PPE) and reduce exposures while maintaining glucose control (4,5). In early April 2020, the U.S. Food and Drug Administration notified continuous glucose monitoring (CGM) device manufacturers that it would not object to inpatient use of CGM systems (6), and recent reports have shown the feasibility of remote glucose monitoring in patients with COVID-19 using CGM in the hospital (7–10).

While inpatient use of CGM outside of the intensive care unit (ICU) may reduce patient-provider interactions, more significant benefit is likely to be observed among patients receiving continuous insulin infusion (CII) who require hourly point-of-care (POC) glucose testing. This POC glucose testing burden during a public health crisis could lead to the use of subcutaneous insulin regimens in situations where CII would normally be indicated. Moreover, the severity of illness and clinical characteristics of ICU patients with COVID-19 (i.e., vasopressor requirements, medical nutrition therapy, high-dose glucocorticoid therapy, renal failure), make the safety and efficacy of subcutaneous insulin regimens difficult to maintain (10). Therefore, it is paramount to develop protocols that reduce PPE waste, nursing workload, and infectious exposures while maintaining glycemic control and reducing the risk of iatrogenic hypoglycemia.

Based on 1) our preliminary data using CGM in the cardiac ICU (11), 2) inpatient CGM use in non-ICU units (NCT03877068, NCT03832907), 3) experience with computerized decision support algorithms in the ICU (12–14), and 4) our inpatient clinical practice, we emergently implemented a hybrid CGM/POC glucose testing protocol linked to a computerized CII algorithm along with electronic health record (EHR) documentation to care for critically ill patients with active or suspected COVID-19 at Grady Memorial Hospital in Atlanta, GA. We report here our proof-of-concept with our first nine patients.

Research Design and Methods

Diabetes Technology and EHR Documentation in the ICU

POC glucose values were obtained with a Food and Drug Administration-approved POC glucometer (Nova StatStrip) to measure arterial or capillary glucose. We used a factory-calibrated CGM device (Dexcom G6) including three platforms:

Dexcom G6 App for transmission of sensor data to a smartphone (with internet connectivity) placed outside (within 20 feet) the patient’s room.

Follow App for remote monitoring (PharmD and endocrinologists) and glucose telemetry (tablet) at the nursing station (15).

Clarity Dashboard for population-based data monitoring.

We used Glucommander, a computerized algorithm integrated in our hospital’s EHR (EPIC) to provide computer-guided CII adjustments. The software adjusts the multiplier according to glucose trends, insulin sensitivity, and response to therapy and has been associated with faster achievement of glucose targets and a reduction in iatrogenic hypoglycemia (13,14). For documentation and validation of CGM sensor values, we created a flowsheet in EPIC (see Supplementary Material). Initial CGM sensor validation was confirmed if there was <20% variance compared with POC glucose values for 2 consecutive hours. Sensor validation was assessed once every 6 h thereafter. Only POC glucose values were used for glucose levels <100 mg/dL.

We report data for nine patients treated on this hybrid protocol, including clinical characteristics, glycemic control metrics, insulin requirements, sensor interferences, and POC testing frequency. The study was approved by the Emory Institutional Review Board.

Results

Patients with diabetes and active or suspected COVID-19 (seven of nine had confirmed PCR testing) started the hybrid CGM/POC + Glucommander protocol with improvement in glycemic control within 12 h and consistent validation for most sensor values. Figure 1 shows superimposed POC and CGM glucose trends and hourly insulin doses. The arrows show conditions associated with CGM/POC discrepancies.

Figure 1

POC (Nova StatStrip glucose meter), real-time CGM (Dexcom G6), and hourly insulin requirements in critically ill patients treated with a computerized CII algorithm (Glucommander). Labeled boxes show identified interferences.

The mean age was 65.9 ± 15.2 years, 67% were men (n = 6), and 89% were African American (n = 8). All patients had type 2 diabetes and blood glucose values >180 mg/dL before starting CII. All patients were on mechanical ventilation and were treated with steroids. Six (67%) were receiving renal replacement therapy. Patient characteristics are summarized in Supplementary Table 1. Eight of nine sensors met initial validation criteria after sensor warm-up (Supplementary Fig. 1).

During hypoperfusion (i.e., pulseless electrical activity, shock), sensor glucose values read lower compared with arterial POC samples, with a sharp decline in sensor values and subsequent signal loss during cardiac arrest and defibrillator use. Similar findings (negative sensor glucose bias) were observed with therapeutic hypothermia protocols and during pronation or position changes causing sensor compression (e.g., bathing). All discrepancies were remotely recognized with alarms. During these interferences, glucose testing reverted to POC testing alone, and the hybrid protocol was resumed after sensor revalidation. Potential interferences are summarized in Supplementary Table 2.

The mean duration on the CGM/POC hybrid protocol with CII was 3.6 ± 2.2 days. Two patients (patients 4 and 5) resumed CII with CGM due to rebound hyperglycemia after initial transition to subcutaneous insulin. During time on the hybrid protocol, 75.7% of sensor glucose values >100 mg/dL were within 20% of the reference POC glucose comparator (validation criteria), with a mean number of POC glucose tests per day of 8.24 ± 3.06. Assuming hourly POC glucose testing requirements during CII, the hybrid protocol resulted in a 63% reduction in required POC tests. Mean time in range (70–180 mg/dL) was 71.4 ± 13.9%. Time between 180 and 250 mg/dL was 19.8 ± 97% and time >250 mg/dL was 7.5 ± 7.3%. Time below range (<70 mg/dL) was 0.6 ± 0.9%. CGM glycemic control metrics are summarized in Supplementary Fig. 2.

Conclusions

Critically ill patients with diabetes and COVID-19 are commonly on vasopressors, steroids, and medical nutrition therapy and are less likely to achieve recommended glucose targets (140–180 mg/dL) on subcutaneous insulin regimens (10,16). A protocol involving multiple stakeholders to implement a hybrid approach (real-time CGM with POC validation every 6 h) with hourly EHR documentation guiding computerized CII is feasible in the ICU and can reduce POC glucose testing without compromising glycemic control.

Although current real-time CGM sensors are not ready to replace POC testing, given the potential for interferences during intensive care leading to discrepancies between POC and sensor glucose values (i.e., signal loss, sensor compression, hypothermia protocols, hypoperfusion, surgery, MRI), the technology has significantly advanced and can provide meaningful improvements in inpatient care. Several advantages to our approach include 1) a reduction in nursing bedside encounters and PPE use; 2) the ability to achieve and maintain adequate glycemic control; 3) minimization of patient discomfort (fingersticks) and blood loss (arterial/venous samples); 4) remote real-time glucose monitoring by additional staff/consult team and glucose telemetry; 5) EHR documentation to easily assess sensor function and facilitate validation; and 6) a comprehensive remote evaluation of overall performance metrics.

A careful and systematic evaluation of emergent care transformations during these unprecedented times is needed (4). As the health care community works toward a new normal, the use of diabetes technology can help alleviate staff concerns related to work burden, exposure, and PPE consumption, while improving glycemic control during this health care crisis.