Keeron Stone1, Simon Fryer1, James Faulkner2, Michelle L Meyer3, Gabriel Zieff4, Craig Paterson1, Kathryn Burnet4, Elizabeth Kelsch4, Daniel Credeur5, Danielle Lambrick6, Lee Stoner4. 1. School of Sport and Exercise, University of Gloucestershire, Gloucester, United Kingdom. 2. Department of Sport, Exercise and Health, University of Winchester, Winchester, United Kingdom. 3. Department of Emergency Medicine, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States. 4. Department of Exercise and Sport Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States. 5. Department of Biology, Ave Maria University, Ave Maria, FL, United States. 6. School of Health Sciences, University of Southampton, Southampton, United Kingdom.
Abstract
Background: Carotid-femoral pulse-wave velocity (cfPWV) is the reference standard measure of central arterial stiffness. However, it requires assessment of the carotid artery, which is technically challenging, and subject-level factors, including carotid artery plaque, may confound measurements. A promising alternative that overcomes these limitations is heart-femoral PWV (hfPWV), but it is not known to what extent changes in cfPWV and hfPWV are associated. Objectives: To determine, (1) the strength of the association between hfPWV and cfPWV; and (2) whether change in hfPWV is associated with change in cfPWV when central arterial stiffness is perturbed. Methods: Twenty young, healthy adults [24.0 (SD: 3.1) years, 45% female] were recruited. hfPWV and cfPWV were determined using Doppler ultrasound at baseline and following a mechanical perturbation in arterial stiffness (120 mmHg thigh occlusion). Agreement between the two measurements was determined using mixed-effects regression models and Bland-Altman analysis. Results: There was, (1) strong (ICC > 0.7) agreement between hfPWV and cfPWV (ICC = 0.82, 95%CI: 0.69, 0.90), and, (2) very strong (ICC > 0.9) agreement between change in hfPWV and cfPWV (ICC = 0.92, 95%CI: 0.86, 0.96). cfPWV was significantly greater than hfPWV at baseline and during thigh occlusion (both P < 0.001). Inspection of the Bland-Altman plot, comparing cfPWV and corrected hfPWV, revealed no measurement magnitude bias. Discussion: The current findings indicate that hfPWV and cfPWV are strongly associated, and that change in cfPWV is very strongly associated with change in hfPWV. hfPWV may be a simple alternative to cfPWV in the identification of cardiovascular risk in clinical and epidemiological settings.
Background: Carotid-femoral pulse-wave velocity (cfPWV) is the reference standard measure of central arterial stiffness. However, it requires assessment of the carotid artery, which is technically challenging, and subject-level factors, including carotid artery plaque, may confound measurements. A promising alternative that overcomes these limitations is heart-femoral PWV (hfPWV), but it is not known to what extent changes in cfPWV and hfPWV are associated. Objectives: To determine, (1) the strength of the association between hfPWV and cfPWV; and (2) whether change in hfPWV is associated with change in cfPWV when central arterial stiffness is perturbed. Methods: Twenty young, healthy adults [24.0 (SD: 3.1) years, 45% female] were recruited. hfPWV and cfPWV were determined using Doppler ultrasound at baseline and following a mechanical perturbation in arterial stiffness (120 mmHg thigh occlusion). Agreement between the two measurements was determined using mixed-effects regression models and Bland-Altman analysis. Results: There was, (1) strong (ICC > 0.7) agreement between hfPWV and cfPWV (ICC = 0.82, 95%CI: 0.69, 0.90), and, (2) very strong (ICC > 0.9) agreement between change in hfPWV and cfPWV (ICC = 0.92, 95%CI: 0.86, 0.96). cfPWV was significantly greater than hfPWV at baseline and during thigh occlusion (both P < 0.001). Inspection of the Bland-Altman plot, comparing cfPWV and corrected hfPWV, revealed no measurement magnitude bias. Discussion: The current findings indicate that hfPWV and cfPWV are strongly associated, and that change in cfPWV is very strongly associated with change in hfPWV. hfPWV may be a simple alternative to cfPWV in the identification of cardiovascular risk in clinical and epidemiological settings.
Authors: Michael H Olsen; Sonia Y Angell; Samira Asma; Pierre Boutouyrie; Dylan Burger; Julio A Chirinos; Albertino Damasceno; Christian Delles; Anne-Paule Gimenez-Roqueplo; Dagmara Hering; Patricio López-Jaramillo; Fernando Martinez; Vlado Perkovic; Ernst R Rietzschel; Giuseppe Schillaci; Aletta E Schutte; Angelo Scuteri; James E Sharman; Kristian Wachtell; Ji Guang Wang Journal: Lancet Date: 2016-09-23 Impact factor: 79.321
Authors: Grzegorz Styczynski; Adam Rdzanek; Arkadiusz Pietrasik; Janusz Kochman; Zenon Huczek; Piotr Sobieraj; Zbigniew Gaciong; Cezary Szmigielski Journal: J Am Soc Echocardiogr Date: 2016-09-07 Impact factor: 5.251