Wassila Nacer 1 , Fatima Zohra Baba Ahmed 1 , Hafida Merzouk 1 , Ouahiba Benyagoub 1 , Samira Bouanane 1 Show Affiliations »
Abstract
PURPOSE: This study aims to evaluate the anti-inflammatory and antioxidant effects of N. gaditana on streptozotocin (STZ)-induced diabetes mellitus in Wistar rats. METHODS: Diabetes was induced in male Wistar rats by single intraperitoneal injection of STZ (45 mg/kg). Male rats were fed on control diet supplemented or not with N. gaditana (10%) for a period of 2 months. At the end of the experiment, biochemical parameters and oxidant/antioxidant markers in liver and pancreas tissues, as well as mitochondria isolated from liver of rats, were determined. RESULTS: It was notice that levels of glucose, glycated hemoglobin (HbA1c), lipid profile, kidney functions and liver enzymes in addition to markers of the inflammatory reactions interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) increased significantly (P < 0.05) in diabetic rats. Moreover, undesirable alterations of oxidative stress markers of tissue and mitochondria isolated from the liver were noted in these rats. N. gaditana supplementation was shown effective in lowering the levels of glucose, HbA1c and improving the renal and hepatic function and also in attenuating the oxidative stress and inflammation in diabetic rats. CONCLUSION: N. gaditana possesses antioxidant properties that might have beneficial effect in treatment of diabetes. © Springer Nature Switzerland AG 2020.
PURPOSE: This study aims to evaluate the anti-inflammatory and antioxidant effects of N. gaditana on streptozotocin (STZ)-induced diabetes mellitus in Wistar rats. METHODS: Diabetes was induced in male Wistar rats by single intraperitoneal injection of STZ (45 mg/kg). Male rats were fed on control diet supplemented or not with N. gaditana (10%) for a period of 2 months. At the end of the experiment, biochemical parameters and oxidant/antioxidant markers in liver and pancreas tissues, as well as mitochondria isolated from liver of rats, were determined. RESULTS: It was notice that levels of glucose, glycated hemoglobin (HbA1c), lipid profile, kidney functions and liver enzymes in addition to markers of the inflammatory reactions interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) increased significantly (P < 0.05) in diabetic rats. Moreover, undesirable alterations of oxidative stress markers of tissue and mitochondria isolated from the liver were noted in these rats. N. gaditana supplementation was shown effective in lowering the levels of glucose, HbA1c and improving the renal and hepatic function and also in attenuating the oxidative stress and inflammation in diabetic rats. CONCLUSION: N. gaditana possesses antioxidant properties that might have beneficial effect in treatment of diabetes. © Springer Nature Switzerland AG 2020.
Entities: Chemical
Keywords:
Diabetes; Inflammation; Mitochondria; Nannochloropsis gaditana; Oxidative stress
Year: 2020
PMID： 33553035 PMCID： PMC7843831 DOI： 10.1007/s40200-020-00681-3
Source DB: PubMed Journal: J Diabetes Metab Disord ISSN： 2251-6581