Kenneth I Berger1, Ori Adam2, Roberto Walter Dal Negro3, David A Kaminsky4, Robert J Shiner5, Felip Burgos6, Frans H C de Jongh7, Inon Cohen8, Jeffrey J Fredberg9. 1. Division of Pulmonary Critical Care and Sleep Medicine, NYU Grossman School of Medicine, Bellevue Hospital, New York, NY; André Cournand Pulmonary Physiology Laboratory, Bellevue Hospital, New York, NY. Electronic address: Kenneth.berger@nyumc.org. 2. Institute of Earth Sciences, Hebrew University, Jerusalem, Israel. 3. Centro Nazionale Studi di Farmacoeconomia e Farmacoepidemiologia Respiratoria, CESFAR, Verona, Italy. 4. Pulmonary and Critical Care Medicine, The University of Vermont Larner College of Medicine, Burlington, VT. 5. Herzliya Medical Center, Herzliya Pituach, Israel. 6. Servicio de Pneumologia, Hospital Clínic, Instituto de Investigaciones Biomédicas August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain. 7. Department of Pulmonary Function, Medisch Spectrum Twente, Enschede, The Netherlands. 8. Division of Pulmonary Critical Care and Sleep Medicine, NYU Grossman School of Medicine, Bellevue Hospital, New York, NY. 9. Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA.
Abstract
BACKGROUND: Current techniques for measuring absolute lung volumes rely on bulky and expensive equipment and are complicated to use for the operator and the patient. A novel method for measurement of absolute lung volumes, the MiniBox method, is presented. RESEARCH QUESTION: Across a population of patients and healthy participants, do values for total lung capacity (TLC) determined by the novel compact device (MiniBox, PulmOne Advanced Medical Devices, Ltd.) compare favorably with measurements determined by traditional whole body plethysmography? STUDY DESIGN AND METHODS: A total of 266 participants (130 men) and respiratory patients were recruited from five global centers (three in Europe and two in the United States). The study population comprised individuals with obstructive (n = 197) and restrictive (n = 33) disorders as well as healthy participants (n = 36). TLC measured by conventional plethysmography (TLCPleth) was compared with TLC measured by the MiniBox (TLCMB). RESULTS: TLC values ranged between 2.7 and 10.9 L. The normalized root mean square difference (NSD) between TLCPleth and TLCMB was 7.0% in healthy participants. In obstructed patients, the NSD was 7.9% in mild obstruction and 9.1% in severe obstruction. In restricted patients, the NSD was 7.8% in mild restriction and 13.9% in moderate and severe restriction. No significant differences were found between TLC values obtained by the two measurement techniques. Also no significant differences were found in results obtained among the five centers. INTERPRETATION: TLC as measured by the novel MiniBox system is not significantly different from TLC measured by conventional whole body plethysmography, thus validating the MiniBox method as a reliable method to measure absolute lung volumes.
BACKGROUND: Current techniques for measuring absolute lung volumes rely on bulky and expensive equipment and are complicated to use for the operator and the patient. A novel method for measurement of absolute lung volumes, the MiniBox method, is presented. RESEARCH QUESTION: Across a population of patients and healthy participants, do values for total lung capacity (TLC) determined by the novel compact device (MiniBox, PulmOne Advanced Medical Devices, Ltd.) compare favorably with measurements determined by traditional whole body plethysmography? STUDY DESIGN AND METHODS: A total of 266 participants (130 men) and respiratory patients were recruited from five global centers (three in Europe and two in the United States). The study population comprised individuals with obstructive (n = 197) and restrictive (n = 33) disorders as well as healthy participants (n = 36). TLC measured by conventional plethysmography (TLCPleth) was compared with TLC measured by the MiniBox (TLCMB). RESULTS: TLC values ranged between 2.7 and 10.9 L. The normalized root mean square difference (NSD) between TLCPleth and TLCMB was 7.0% in healthy participants. In obstructed patients, the NSD was 7.9% in mild obstruction and 9.1% in severe obstruction. In restricted patients, the NSD was 7.8% in mild restriction and 13.9% in moderate and severe restriction. No significant differences were found between TLC values obtained by the two measurement techniques. Also no significant differences were found in results obtained among the five centers. INTERPRETATION: TLC as measured by the novel MiniBox system is not significantly different from TLC measured by conventional whole body plethysmography, thus validating the MiniBox method as a reliable method to measure absolute lung volumes.
Authors: Ciro Casanova; Claudia Cote; Juan P de Torres; Armando Aguirre-Jaime; Jose M Marin; Victor Pinto-Plata; Bartolome R Celli Journal: Am J Respir Crit Care Med Date: 2004-12-10 Impact factor: 21.405