| Literature DB >> 33534886 |
Daniel Kepple1, Alfred Hubbard2, Musab M Ali3, Beka R Abargero4, Karen Lopez2, Kareen Pestana1, Daniel A Janies2, Guiyun Yan5, Muzamil Mahdi Hamid3, Delenasaw Yewhalaw4,6, Eugenia Lo1.
Abstract
Plasmodium vivax malaria was thought to be rare in Africa, but an increasing number of P. vivax cases reported across Africa and in Duffy-negative individuals challenges this dogma. The genetic characteristics of P. vivax in Duffy-negative infections, the transmission of P. vivax in East Africa, and the impact of environments on transmission remain largely unknown. This study examined genetic and transmission features of P. vivax from 107 Duffy-negative and 305 Duffy-positive individuals in Ethiopia and Sudan. No clear genetic differentiation was found in P. vivax between the 2 Duffy groups, indicating between-host transmission. P. vivax from Ethiopia and Sudan showed similar genetic clusters, except samples from Khartoum, possibly due to distance and road density that inhibited parasite gene flow. This study is the first to show that P. vivax can transmit to and from Duffy-negative individuals and provides critical insights into the spread of P. vivax in sub-Saharan Africa.Entities:
Keywords: zzm321990 Plasmodium vivaxzzm321990 ; Duffy-negative; East Africa; genetic diversity; transmission pathways
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Year: 2021 PMID： 33534886 PMCID： PMC8557672 DOI： 10.1093/infdis/jiab063
Source DB: PubMed Journal: J Infect Dis ISSN： 0022-1899 Impact factor: 5.226