Alison X Chan1, Christine Y Bakhoum1, Katherine J Bangen1, Mathieu F Bakhoum2. 1. From the Viterbi Family Department of Ophthalmology (AXC, MFB), Shiley Eye Institute, University of California San Diego, La Jolla, California, USA; Division of Pediatric Nephrology (CYB), Rady Children's Hospital San Diego, University of California San Diego, San Diego, California, USA; Research Service (KJB), Veterans' Affairs San Diego Healthcare System, La Jolla, California, USA; Department of Psychiatry (KJB), University of California San Diego, La Jolla, California. 2. From the Viterbi Family Department of Ophthalmology (AXC, MFB), Shiley Eye Institute, University of California San Diego, La Jolla, California, USA; Division of Pediatric Nephrology (CYB), Rady Children's Hospital San Diego, University of California San Diego, San Diego, California, USA; Research Service (KJB), Veterans' Affairs San Diego Healthcare System, La Jolla, California, USA; Department of Psychiatry (KJB), University of California San Diego, La Jolla, California. Electronic address: mathieu.bakhoum@gmail.com.
Abstract
PURPOSE: To examine the association between cognitive dementia and retinal vascular occlusions. DESIGN: A retrospective, cross-sectional study. METHODS: Single-institution study population: we reviewed the electronic medical records of 37,208 individuals older than 65 years of age who were evaluated by an ophthalmologist or an optometrist and who also had a medical visit to our institution over a 6-year period. Individuals with and without retinal vascular occlusions were identified by International Classification of Diseases, version 10 (ICD-10) diagnostic codes. MAIN OUTCOME: we analyzed the association between dementia and retinal vascular occlusions after adjusting for covariates which included age, sex, stroke, diabetes mellitus, and hypertension using multiple logistic regression analyses. RESULTS: Compared to subjects without retinal vascular occlusions, those with retinal vascular occlusions had a higher prevalence of dementia (6.7% vs. 9.3%, respectively; P < .001). After adjusting for either age or stroke, there were no significant associations between retinal vascular occlusions and dementia. CONCLUSIONS: Individuals with retinal vascular occlusions have a higher prevalence of dementia. However, this association is secondary to shared underlying risk factors in this population, such as older age and stroke.
PURPOSE: To examine the association between cognitive dementia and retinal vascular occlusions. DESIGN: A retrospective, cross-sectional study. METHODS: Single-institution study population: we reviewed the electronic medical records of 37,208 individuals older than 65 years of age who were evaluated by an ophthalmologist or an optometrist and who also had a medical visit to our institution over a 6-year period. Individuals with and without retinal vascular occlusions were identified by International Classification of Diseases, version 10 (ICD-10) diagnostic codes. MAIN OUTCOME: we analyzed the association between dementia and retinal vascular occlusions after adjusting for covariates which included age, sex, stroke, diabetes mellitus, and hypertension using multiple logistic regression analyses. RESULTS: Compared to subjects without retinal vascular occlusions, those with retinal vascular occlusions had a higher prevalence of dementia (6.7% vs. 9.3%, respectively; P < .001). After adjusting for either age or stroke, there were no significant associations between retinal vascular occlusions and dementia. CONCLUSIONS: Individuals with retinal vascular occlusions have a higher prevalence of dementia. However, this association is secondary to shared underlying risk factors in this population, such as older age and stroke.
Authors: Katharina A Ponto; Inge Scharrer; Harald Binder; Christina Korb; Ann K Rosner; Till O Ehlers; Nikola Rieser; Nadja C Grübel; Heidi Rossmann; Philipp S Wild; Nicolas Feltgen; Norbert Pfeiffer; Alireza Mirshahi Journal: J Hypertens Date: 2019-07 Impact factor: 4.844
Authors: Christine Benn Christiansen; Christian Torp-Pedersen; Jonas Bjerring Olesen; Gunnar Gislason; Morten Lamberts; Nicholas Carlson; Mathias Buron; Nikolai Juul; Gregory Y H Lip Journal: BMC Cardiovasc Disord Date: 2018-05-10 Impact factor: 2.298
Authors: Christopher P Long; Alison X Chan; Christine Y Bakhoum; Christopher B Toomey; Samantha Madala; Anupam K Garg; William R Freeman; Michael H Goldbaum; Anthony N DeMaria; Mathieu F Bakhoum Journal: EClinicalMedicine Date: 2021-03-02