Matteo Fallico1,2, Andrew J Lotery3,4, Antonio Longo5, Teresio Avitabile5, Vincenza Bonfiglio5, Andrea Russo5, Paolo Murabito6, Stefano Palmucci7, Alfredo Pulvirenti8, Michele Reibaldi5. 1. Department of Ophthalmology, University of Catania, Catania, Italy. matteo.fallico@uhs.nhs.uk. 2. Eye Unit, Southampton University Hospital, Southampton, UK. matteo.fallico@uhs.nhs.uk. 3. Eye Unit, Southampton University Hospital, Southampton, UK. 4. Faculty of Medicine, University of Southampton, Southampton, UK. 5. Department of Ophthalmology, University of Catania, Catania, Italy. 6. Department of Anaesthesiology, University of Catania, Catania, Italy. 7. Department of Medical Surgical Sciences and Advanced Technologies - Radiology I Unit, University of Catania, Catania, Italy. 8. Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy.
Abstract
OBJECTIVE: To estimate the incidence of acute cerebral ischaemia detected by magnetic resonance imaging (MRI) in acute central retinal artery occlusion (CRAO), branch retinal artery occlusion (BRAO) and transient monocular vision loss (TMVL). METHODS: Studies reporting the incidence of acute cerebral ischaemia, detected by MRI, within 7 days from diagnosis of acute CRAO, BRAO and TMVL up to January 2019 were systematically searched for on Pubmed, Medline and Cochrane Library. Meta-analysis was performed using random effects model. The primary outcome was the pooled estimate of incidence of acute cerebral ischaemia in CRAO, BRAO and TMVL cohorts including both neurologically symptomatic and asymptomatic patients, expressed as a proportion along with 95% confidence intervals (CIs). The pooled estimate of incidence of asymptomatic acute cerebral ischaemia represented a secondary outcome measure. RESULTS: For the primary outcome, the pooled proportion of acute cerebral ischaemia was 0.30 (CI 0.24-0.36) in the CRAO cohort, and 0.25 (CI 0.16-0.37) in the BRAO cohort, without statistical heterogeneity. The rate of acute cerebral ischaemia was 11.8% in the TMVL cohort. For the secondary outcome, the pooled proportion of asymptomatic acute cerebral ischaemia was 0.22 (CI 0.16-0.28) in the CRAO cohort, 0.29 (CI 0.20-0.41) in the BRAO cohort and 0.08 (CI 0.05-0.15) in the TMVL cohort, with no statistical heterogeneity. CONCLUSIONS: 30% of patients with acute CRAO and 25% of patients with acute BRAO presented an acute cerebral ischaemia on MRI. Such high rates support a care pathway of prompt referral of such patients for neurological evaluation and brain imaging.
OBJECTIVE: To estimate the incidence of acute cerebral ischaemia detected by magnetic resonance imaging (MRI) in acute central retinal artery occlusion (CRAO), branch retinal artery occlusion (BRAO) and transient monocular vision loss (TMVL). METHODS: Studies reporting the incidence of acute cerebral ischaemia, detected by MRI, within 7 days from diagnosis of acute CRAO, BRAO and TMVL up to January 2019 were systematically searched for on Pubmed, Medline and Cochrane Library. Meta-analysis was performed using random effects model. The primary outcome was the pooled estimate of incidence of acute cerebral ischaemia in CRAO, BRAO and TMVL cohorts including both neurologically symptomatic and asymptomatic patients, expressed as a proportion along with 95% confidence intervals (CIs). The pooled estimate of incidence of asymptomatic acute cerebral ischaemia represented a secondary outcome measure. RESULTS: For the primary outcome, the pooled proportion of acute cerebral ischaemia was 0.30 (CI 0.24-0.36) in the CRAO cohort, and 0.25 (CI 0.16-0.37) in the BRAO cohort, without statistical heterogeneity. The rate of acute cerebral ischaemia was 11.8% in the TMVL cohort. For the secondary outcome, the pooled proportion of asymptomatic acute cerebral ischaemia was 0.22 (CI 0.16-0.28) in the CRAO cohort, 0.29 (CI 0.20-0.41) in the BRAO cohort and 0.08 (CI 0.05-0.15) in the TMVL cohort, with no statistical heterogeneity. CONCLUSIONS: 30% of patients with acute CRAO and 25% of patients with acute BRAO presented an acute cerebral ischaemia on MRI. Such high rates support a care pathway of prompt referral of such patients for neurological evaluation and brain imaging.
Authors: Patrick Lavin; Morgan Patrylo; Matthew Hollar; Kiersten B Espaillat; Howard Kirshner; Matthew Schrag Journal: Am J Ophthalmol Date: 2018-08-25 Impact factor: 5.258
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Authors: Christopher P Long; Alison X Chan; Christine Y Bakhoum; Christopher B Toomey; Samantha Madala; Anupam K Garg; William R Freeman; Michael H Goldbaum; Anthony N DeMaria; Mathieu F Bakhoum Journal: EClinicalMedicine Date: 2021-03-02
Authors: Matteo Fallico; Andrea Maugeri; Giovanni L Romano; Claudio Bucolo; Antonio Longo; Vincenza Bonfiglio; Andrea Russo; Teresio Avitabile; Martina Barchitta; Antonella Agodi; Francesco Pignatelli; Paola Marolo; Luca Ventre; Guglielmo Parisi; Michele Reibaldi Journal: Front Pharmacol Date: 2021-04-15 Impact factor: 5.810