| Literature DB >> 3352467 |
E A Moja1, D M Stoff, G L Gessa, D Castoldi, R Assereto, O Tofanetti.
Abstract
Male healthy subjects, fasting 12 hours, ingested increasing amounts of a mixture containing a fixed proportion of seven essential amino acids (L-isoleucine 11.5%, L-leucine 18.0%, L-lysine 13.1%, L-methionine 18.0%, L-phenylalanine 18.0%, L-threonine 8.2%, L-valine 13.1%) and lacking tryptophan. The diets produced a rapid fall in plasma tryptophan which was proportional to the total amount of the amino acids ingested. Following the highest dose administered (36.6 g) plasma tryptophan fell to a minimum of about 35% the initial level and remained markedly reduced at 6 hours after treatment. The mechanism of this decrease and its potential clinical relevance are discussed.Entities:
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Year: 1988 PMID： 3352467 DOI： 10.1016/0024-3205(88)90013-6
Source DB: PubMed Journal: Life Sci ISSN： 0024-3205 Impact factor: 5.037