BACKGROUND: Tryptophan depletion (TD) reduces brain serotonin and may induce acute depressive symptomatology, especially among those with a history of Major Depression. Depressive response to TD among euthymic patients with a history of depression also predicts future depression. Better prediction might result by assessing a putative endophenotype for depressive risk, frontal electroencephalographic (EEG) asymmetry, in the context of TD. METHOD: Nine euthymic history-positive participants and nine controls were administered TD. Symptomatic and EEG frontal asymmetry data were collected for 6 h following TD, and clinical status was followed for the next 12 months. RESULTS: The magnitude of TD-induced change in frontal EEG asymmetry significantly predicted the development of depression during the ensuing six to twelve months, and with greater sensitivity than symptomatic response. LIMITATIONS: The results are tempered by the small sample size. CONCLUSIONS: Despite the limited sample size, these preliminary results suggest that TD-induced changes in frontal EEG asymmetry may provide a more sensitive indicator of risk for imminent depression than symptomatic response to TD.
BACKGROUND:Tryptophan depletion (TD) reduces brain serotonin and may induce acute depressive symptomatology, especially among those with a history of Major Depression. Depressive response to TD among euthymic patients with a history of depression also predicts future depression. Better prediction might result by assessing a putative endophenotype for depressive risk, frontal electroencephalographic (EEG) asymmetry, in the context of TD. METHOD: Nine euthymic history-positive participants and nine controls were administered TD. Symptomatic and EEG frontal asymmetry data were collected for 6 h following TD, and clinical status was followed for the next 12 months. RESULTS: The magnitude of TD-induced change in frontal EEG asymmetry significantly predicted the development of depression during the ensuing six to twelve months, and with greater sensitivity than symptomatic response. LIMITATIONS: The results are tempered by the small sample size. CONCLUSIONS: Despite the limited sample size, these preliminary results suggest that TD-induced changes in frontal EEG asymmetry may provide a more sensitive indicator of risk for imminent depression than symptomatic response to TD.
Authors: Alexander Neumeister; Peixiong Yuan; Theresa A Young; Omer Bonne; David A Luckenbaugh; Dennis S Charney; Husseini Manji Journal: Am J Psychiatry Date: 2005-04 Impact factor: 18.112
Authors: Alexander Neumeister; Allison C Nugent; Tracy Waldeck; Marilla Geraci; Markus Schwarz; Omer Bonne; Earle E Bain; David A Luckenbaugh; Peter Herscovitch; Dennis S Charney; Wayne C Drevets Journal: Arch Gen Psychiatry Date: 2004-08
Authors: Andrew W Bismark; Francisco A Moreno; Jennifer L Stewart; David N Towers; James A Coan; Jennifer Oas; Robert P Erickson; John J B Allen Journal: Biol Psychol Date: 2009-12-16 Impact factor: 3.251
Authors: E L Gibson; K Vargas; E Hogan; A Holmes; P J Rogers; J Wittwer; J Kloek; R Goralczyk; M H Mohajeri Journal: Psychopharmacology (Berl) Date: 2014-05-25 Impact factor: 4.530