RATIONALE AND OBJECTIVE: In animal and human studies, the neurotransmitter serotonin (5-hydroxytryptamine; 5-HT) has been implicated in mediating impulsiveness and aggression. To test the hypothesis that 5-HT modulates neuro-cognitive brain activation during inhibitory control, we examined the effect of acute tryptophan depletion (ATD), a dietary challenge, which has been shown to decrease 5-HT synthesis in the brain, on functional brain activation during a go/no-go task. METHODS:Nine healthy, right-handed volunteers performed a rapid, event-related go/no-go task in twofunctional magnetic resonance imaging (fMRI) scanning sessions, 5 h after either a tryptophan-free or a balanced amino acid drink in a double-blind, sham depletion-controlled, counterbalanced, crossover design. The task required subjects to selectively execute or inhibit a motor response. Tryptophan depletion significantly lowered total plasma tryptophan concentration by 80%, but did not significantly alter inhibitory performance or mood ratings. RESULTS: ATD significantly reduced right orbito-inferior prefrontal activation during the no-go condition, and increased activation in superior and medial temporal cortices. CONCLUSIONS: These findings provide neuro-functional evidence of a serotonergic modulation of right inferior prefrontal during inhibitory motor control. The increased engagement of temporal brain regions may reflect compensatory mechanisms.
RCT Entities:
RATIONALE AND OBJECTIVE: In animal and human studies, the neurotransmitter serotonin (5-hydroxytryptamine; 5-HT) has been implicated in mediating impulsiveness and aggression. To test the hypothesis that 5-HT modulates neuro-cognitive brain activation during inhibitory control, we examined the effect of acute tryptophan depletion (ATD), a dietary challenge, which has been shown to decrease 5-HT synthesis in the brain, on functional brain activation during a go/no-go task. METHODS: Nine healthy, right-handed volunteers performed a rapid, event-related go/no-go task in two functional magnetic resonance imaging (fMRI) scanning sessions, 5 h after either a tryptophan-free or a balanced amino acid drink in a double-blind, sham depletion-controlled, counterbalanced, crossover design. The task required subjects to selectively execute or inhibit a motor response. Tryptophan depletion significantly lowered total plasma tryptophan concentration by 80%, but did not significantly alter inhibitory performance or mood ratings. RESULTS:ATD significantly reduced right orbito-inferior prefrontal activation during the no-go condition, and increased activation in superior and medial temporal cortices. CONCLUSIONS: These findings provide neuro-functional evidence of a serotonergic modulation of right inferior prefrontal during inhibitory motor control. The increased engagement of temporal brain regions may reflect compensatory mechanisms.
Authors: W Sommer; C Möller; L Wiklund; A Thorsell; R Rimondini; H Nissbrandt; M Heilig Journal: Neuropsychopharmacology Date: 2001-04 Impact factor: 7.853
Authors: J S Rubinsztein; R D Rogers; W J Riedel; M A Mehta; T W Robbins; B J Sahakian Journal: Psychopharmacology (Berl) Date: 2001-03 Impact factor: 4.530
Authors: D G LeMarquand; R O Pihl; S N Young; R E Tremblay; J R Séguin; R M Palmour; C Benkelfat Journal: Neuropsychopharmacology Date: 1998-10 Impact factor: 7.853
Authors: Matthew J Hoptman; Jan Volavka; Glyn Johnson; Elisabeth Weiss; Robert M Bilder; Kelvin O Lim Journal: Biol Psychiatry Date: 2002-07-01 Impact factor: 13.382
Authors: Paul P Allen; Anthony J Cleare; Francis Lee; Paolo Fusar-Poli; Nigel Tunstall; Cynthia H Y Fu; Micheal J Brammer; Philip K McGuire Journal: Psychopharmacology (Berl) Date: 2006-07-06 Impact factor: 4.530
Authors: Elisabeth A T Evers; Frederik M van der Veen; Jeroen A van Deursen; Jeroen A J Schmitt; Nicolaas E P Deutz; Jelle Jolles Journal: Psychopharmacology (Berl) Date: 2006-05-19 Impact factor: 4.530
Authors: Robin L Carhart-Harris; David J Nutt; Marcus R Munafo; David M Christmas; Sue J Wilson Journal: Psychopharmacology (Berl) Date: 2009-07-08 Impact factor: 4.530
Authors: Katya Rubia; Ana Cubillo; Anna B Smith; James Woolley; Isobel Heyman; Michael J Brammer Journal: Hum Brain Mapp Date: 2010-02 Impact factor: 5.038