Literature DB >> 3350126

Goniothalamicin and annonacin: bioactive acetogenins from Goniothalamus giganteus (Annonaceae).

A Alkofahi1, J K Rupprecht, D L Smith, C J Chang, J L McLaughlin.   

Abstract

Using brine shrimp lethality for activity-directed fractionation, goniothalamicin (I), a new tetrahydroxy-mono-tetrahydrofuran fatty acid gamma-lactone (acetogenin), has been isolated from ethanolic extracts of the stem bark of Goniothalamus giganteus Hook. f., Thomas (Annonaceae). This novel compound was found to be cytotoxic and insecticidal and inhibited the formation of crown gall tumors on potato discs. Annonacin (II), the only other reported mono-tetrahydrofuran acetogenin, was also isolated; the previously reported 9ASK (astrocytoma reversal) activity of II was confirmed, and II is now also found to be weakly active against 3PS murine leukemia.

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Year:  1988        PMID： 3350126     DOI： 10.1007/bf01960258

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  4 in total

1.  Annonacin, a novel, biologically active polyketide from Annona densicoma.

Authors:  T G McCloud; D L Smith; C J Chang; J M Cassady
Journal:  Experientia       Date:  1987-08-15

2.  Use of the KB cell line for in vitro cytotoxicity assays.

Authors:  R H Shoemaker; B J Abbott; M M Macdonald; J G Mayo; J M Venditti; M K Wolpert-DeFilippes
Journal:  Cancer Treat Rep       Date:  1983-01

3.  Brine shrimp: a convenient general bioassay for active plant constituents.

Authors:  B N Meyer; N R Ferrigni; J E Putnam; L B Jacobsen; D E Nichols; J L McLaughlin
Journal:  Planta Med       Date:  1982-05       Impact factor: 3.352

4.  Modification and evaluation of the potato disc assay and antitumor screening of euphorbiaceae seeds.

Authors:  N R Ferrigni; J E Putnam; B Anderson; L B Jacobsen; D E Nichols; D S Moore; J L McLaughlin; R G Powell; C R Smith
Journal:  J Nat Prod       Date:  1982 Nov-Dec       Impact factor: 4.050
  4 in total
  5 in total

Review 1.  Sylvaticin: a new cytotoxic and insecticidal acetogenin from Rollinia sylvatica (Annonaceae).

Authors:  K J Mikolajczak; R V Madrigal; J K Rupprecht; Y H Hui; Y M Liu; D L Smith; J L McLaughlin
Journal:  Experientia       Date:  1990-03-15

2.  Gigantecin: a novel antimitotic and cytotoxic acetogenin, with nonadjacent tetrahydrofuran rings, from Goniothalamus giganteus (Annonaceae).

Authors:  A Alkofahi; J K Rupprecht; Y M Liu; C J Chang; D L Smith; J L McLaughlin
Journal:  Experientia       Date:  1990-05-15

3.  Cytotoxic and cytostatic effects of four Annonaceae plants on human cancer cell lines.

Authors:  Kitti Pumiputavon; Tanawat Chaowasku; Chalermpong Saenjum; Maslin Osathanunkul; Boonsong Wungsintaweekul; Kriangkrai Chawansuntati; Pathrapol Lithanatudom; Jiraprapa Wipasa
Journal:  In Vitro Cell Dev Biol Anim       Date:  2019-08-26       Impact factor: 2.416

4.  Goniothalamus species: a source of drugs for the treatment of cancers and bacterial infections?

Authors:  Christophe Wiart
Journal:  Evid Based Complement Alternat Med       Date:  2007-09       Impact factor: 2.629

5.  Recent progress on the total synthesis of acetogenins from Annonaceae.

Authors:  Nianguang Li; Zhihao Shi; Yuping Tang; Jianwei Chen; Xiang Li
Journal:  Beilstein J Org Chem       Date:  2008-12-05       Impact factor: 2.883
  5 in total

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