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Literature DB >> 3622737

Annonacin, a novel, biologically active polyketide from Annona densicoma.

T G McCloud, D L Smith, C J Chang, J M Cassady.

Abstract

A new linear polyketide, Annonacin (I), has been isolated from active extracts of the stembark of Annona densicoma Mart. Annonacin (I) is highly cytotoxic and is active in an assay designed to detect antimitotic agents. The structure of (I) was determined by analysis of spectroscopic data.

Entities: Chemical

Mesh：

Substances：

Year: 1987 PMID： 3622737 DOI： 10.1007/bf01951681

Source DB: PubMed Journal: Experientia ISSN： 0014-4754

1 in total

1. Rollinone, a new cytotoxic acetogenin from Rollinia papilionella.

Authors: T T Dabrah; A T Sneden
Journal: J Nat Prod Date: 1984 Jul-Aug Impact factor: 4.050

1 in total

5 in total

Review 1. Sylvaticin: a new cytotoxic and insecticidal acetogenin from Rollinia sylvatica (Annonaceae).

Authors: K J Mikolajczak; R V Madrigal; J K Rupprecht; Y H Hui; Y M Liu; D L Smith; J L McLaughlin
Journal: Experientia Date: 1990-03-15

2. The alternative medicine pawpaw and its acetogenin constituents suppress tumor angiogenesis via the HIF-1/VEGF pathway.

Authors: Veena Coothankandaswamy; Yang Liu; Shui-Chun Mao; J Brian Morgan; Fakhri Mahdi; Mika B Jekabsons; Dale G Nagle; Yu-Dong Zhou
Journal: J Nat Prod Date: 2010-05-28 Impact factor: 4.050

Annonacin, a novel, biologically active polyketide from Annona densicoma.

1. Rollinone, a new cytotoxic acetogenin from Rollinia papilionella.

Review 1. Sylvaticin: a new cytotoxic and insecticidal acetogenin from Rollinia sylvatica (Annonaceae).

2. The alternative medicine pawpaw and its acetogenin constituents suppress tumor angiogenesis via the HIF-1/VEGF pathway.

3. Goniothalamicin and annonacin: bioactive acetogenins from Goniothalamus giganteus (Annonaceae).

4. Novel Annonaceous acetogenins from Graviola (Annona muricata) fruits with strong anti-proliferative activity.

5. Recent progress on the total synthesis of acetogenins from Annonaceae.