Yemin Yuan1,2, Jie Li1, Nan Zhang3, Peipei Fu1, Zhengyue Jing1, Caiting Yu1, Dan Zhao1, Wenting Hao1, Chengchao Zhou4,5. 1. Centre for Health Management and Policy Research, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, 250012, China. 2. Department of Epidemiology, School of Public Health, Cheeloo College of Medicine, Shandong University, 44 Wenhuaxi Road, Jinan, 250012, Shandong, China. 3. Manchester Institute for Collaborative Research on Ageing, Social Statistics, School of Social Sciences, The University of Manchester, Manchester, UK. 4. Centre for Health Management and Policy Research, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, 250012, China. zhouchengchao@sdu.edu.cn. 5. NHC Key Laboratory of Health Economics and Policy Research, Shandong University, 44 Wenhuaxi Road, Jinan, 250012, Shandong, China. zhouchengchao@sdu.edu.cn.
Abstract
BACKGROUND: Evidence concerning the association between body mass index (BMI) and cognitive function among older people is inconsistent. This study aimed to investigate gender and age as moderators in association between BMI and mild cognitive impairment (MCI) among rural older adults. METHODS: Data were derived from the 2019 Health Service for Rural Elderly Families Survey in Shandong, China. In total, 3242 people aged 60 years and above were included in the analysis. Multilevel mixed-effects logistic regression was used to examine the moderating roles of gender and age, then further to explore the relationship between BMI and MCI. RESULTS: There were 601 (18.5%) participants with MCI. Compared with normal BMI group, low BMI group had a higher risk of MCI among older people [adjusted odds ratio (aOR) = 2.08, 95% confidence interval (CI): 1.26-3.44], women (aOR = 2.06, 95% CI: 1.35-3.12), or the older elderly aged ≥75 years old (aOR = 3.20, 95% CI: 1.34-7.45). This effect remained statistically significant among older women (aOR = 3.38, 95% CI: 1.69-6.73). Among older men, elevated BMI group had a higher risk of MCI (aOR = 2.32, 95% CI: 1.17-4.61) than normal BMI group. CONCLUSIONS: Gender and age moderated the association between BMI and MCI among Chinese rural older adults. Older women with low BMI were more likely to have MCI, but older men with elevated BMI were more likely to have MCI. These findings suggest rural community managers strengthen the health management by grouping the weight of older people to prevent the risk of dementia.
BACKGROUND: Evidence concerning the association between body mass index (BMI) and cognitive function among older people is inconsistent. This study aimed to investigate gender and age as moderators in association between BMI and mild cognitive impairment (MCI) among rural older adults. METHODS: Data were derived from the 2019 Health Service for Rural Elderly Families Survey in Shandong, China. In total, 3242 people aged 60 years and above were included in the analysis. Multilevel mixed-effects logistic regression was used to examine the moderating roles of gender and age, then further to explore the relationship between BMI and MCI. RESULTS: There were 601 (18.5%) participants with MCI. Compared with normal BMI group, low BMI group had a higher risk of MCI among older people [adjusted odds ratio (aOR) = 2.08, 95% confidence interval (CI): 1.26-3.44], women (aOR = 2.06, 95% CI: 1.35-3.12), or the older elderly aged ≥75 years old (aOR = 3.20, 95% CI: 1.34-7.45). This effect remained statistically significant among older women (aOR = 3.38, 95% CI: 1.69-6.73). Among older men, elevated BMI group had a higher risk of MCI (aOR = 2.32, 95% CI: 1.17-4.61) than normal BMI group. CONCLUSIONS: Gender and age moderated the association between BMI and MCI among Chinese rural older adults. Older women with low BMI were more likely to have MCI, but older men with elevated BMI were more likely to have MCI. These findings suggest rural community managers strengthen the health management by grouping the weight of older people to prevent the risk of dementia.
Entities:
Keywords:
Age difference; Body mass index; Gender difference; Mild cognitive impairment; Older adults
Authors: Yu A An; Clair Crewe; Ingrid Wernstedt Asterholm; Kai Sun; Shiuhwei Chen; Fang Zhang; Mengle Shao; Jan-Bernd Funcke; Zhuzhen Zhang; Leon Straub; Jun Yoshino; Samuel Klein; Christine M Kusminski; Philipp E Scherer Journal: Nat Metab Date: 2019-12-13
Authors: Rebecca Polk; Marilyn Horta; Tian Lin; Eric Porges; Marite Ojeda; Hans P Nazarloo; C Sue Carter; Natalie C Ebner Journal: Philos Trans R Soc Lond B Biol Sci Date: 2022-07-11 Impact factor: 6.671