Literature DB >> 33479123

JARID2 and AEBP2 regulate PRC2 in the presence of H2AK119ub1 and other histone modifications.

Vignesh Kasinath1, Curtis Beck2, Paul Sauer3,4, Simon Poepsel5,6, Jennifer Kosmatka2, Marco Faini7, Daniel Toso3, Ruedi Aebersold7,8, Eva Nogales1,2,4,9.   

Abstract

Polycomb repressive complexes 1 and 2 (PRC1 and PRC2) cooperate to determine cell identity by epigenetic gene expression regulation. However, the mechanism of PRC2 recruitment by means of recognition of PRC1-mediated H2AK119ub1 remains poorly understood. Our PRC2 cryo-electron microscopy structure with cofactors JARID2 and AEBP2 bound to a H2AK119ub1-containing nucleosome reveals a bridge helix in EZH2 that connects the SET domain, H3 tail, and nucleosomal DNA. JARID2 and AEBP2 each interact with one ubiquitin and the H2A-H2B surface. JARID2 stimulates PRC2 through interactions with both the polycomb protein EED and the H2AK119-ubiquitin, whereas AEBP2 has an additional scaffolding role. The presence of these cofactors partially overcomes the inhibitory effect that H3K4me3 and H3K36me3 exert on core PRC2 (in the absence of cofactors). Our results support a key role for JARID2 and AEBP2 in the cross-talk between histone modifications and PRC2 activity.
Copyright © 2021, American Association for the Advancement of Science.

Entities:  

Mesh：

Substances：

Year:  2021        PMID： 33479123      PMCID： PMC7993630          DOI： 10.1126/science.abc3393

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  57 in total

1.  PHENIX: building new software for automated crystallographic structure determination.

Authors:  Paul D Adams; Ralf W Grosse-Kunstleve; Li Wei Hung; Thomas R Ioerger; Airlie J McCoy; Nigel W Moriarty; Randy J Read; James C Sacchettini; Nicholas K Sauter; Thomas C Terwilliger
Journal:  Acta Crystallogr D Biol Crystallogr       Date:  2002-10-21

2.  Reconstitution of nucleosome core particles from recombinant histones and DNA.

Authors:  Pamela N Dyer; Raji S Edayathumangalam; Cindy L White; Yunhe Bao; Srinivas Chakravarthy; Uma M Muthurajan; Karolin Luger
Journal:  Methods Enzymol       Date:  2004       Impact factor: 1.600

3.  Histone monoubiquitylation position determines specificity and direction of enzymatic cross-talk with histone methyltransferases Dot1L and PRC2.

Authors:  Sarah J Whitcomb; Beat Fierz; Robert K McGinty; Matthew Holt; Takashi Ito; Tom W Muir; C David Allis
Journal:  J Biol Chem       Date:  2012-05-22       Impact factor: 5.157

4.  RNA exploits an exposed regulatory site to inhibit the enzymatic activity of PRC2.

Authors:  Qi Zhang; Nicholas J McKenzie; Robert Warneford-Thomson; Emma H Gail; Sarena F Flanigan; Brady M Owen; Richard Lauman; Vitalina Levina; Benjamin A Garcia; Ralf B Schittenhelm; Roberto Bonasio; Chen Davidovich
Journal:  Nat Struct Mol Biol       Date:  2019-03-04       Impact factor: 15.369

5.  Nucleation and Propagation of Heterochromatin by the Histone Methyltransferase PRC2: Geometric Constraints and Impact of the Regulatory Subunit JARID2.

Authors:  Eva J Ge; Krupa S Jani; Katharine L Diehl; Manuel M Müller; Tom W Muir
Journal:  J Am Chem Soc       Date:  2019-09-17       Impact factor: 15.419

6.  H3K36 methylation antagonizes PRC2-mediated H3K27 methylation.

Authors:  Wen Yuan; Mo Xu; Chang Huang; Nan Liu; She Chen; Bing Zhu
Journal:  J Biol Chem       Date:  2011-01-14       Impact factor: 5.157

7.  Positive-unlabeled convolutional neural networks for particle picking in cryo-electron micrographs.

Authors:  Tristan Bepler; Andrew Morin; Micah Rapp; Julia Brasch; Lawrence Shapiro; Alex J Noble; Bonnie Berger
Journal:  Nat Methods       Date:  2019-10-07       Impact factor: 28.547

8.  PRC2 binds active promoters and contacts nascent RNAs in embryonic stem cells.

Authors:  Syuzo Kaneko; Jinsook Son; Steven S Shen; Danny Reinberg; Roberto Bonasio
Journal:  Nat Struct Mol Biol       Date:  2013-10-20       Impact factor: 15.369

9.  Structure of the transcription coactivator SAGA.

Authors:  Haibo Wang; Christian Dienemann; Alexandra Stützer; Henning Urlaub; Alan C M Cheung; Patrick Cramer
Journal:  Nature       Date:  2020-01-22       Impact factor: 49.962

10.  COSMIC: the Catalogue Of Somatic Mutations In Cancer.

Authors:  John G Tate; Sally Bamford; Harry C Jubb; Zbyslaw Sondka; David M Beare; Nidhi Bindal; Harry Boutselakis; Charlotte G Cole; Celestino Creatore; Elisabeth Dawson; Peter Fish; Bhavana Harsha; Charlie Hathaway; Steve C Jupe; Chai Yin Kok; Kate Noble; Laura Ponting; Christopher C Ramshaw; Claire E Rye; Helen E Speedy; Ray Stefancsik; Sam L Thompson; Shicai Wang; Sari Ward; Peter J Campbell; Simon A Forbes
Journal:  Nucleic Acids Res       Date:  2019-01-08       Impact factor: 16.971
View more
  36 in total

1.  Competition between PRC2.1 and 2.2 subcomplexes regulates PRC2 chromatin occupancy in human stem cells.

Authors:  Daniel T Youmans; Anne R Gooding; Robin D Dowell; Thomas R Cech
Journal:  Mol Cell       Date:  2020-12-17       Impact factor: 17.970

2.  Cooperative DNA looping by PRC2 complexes.

Authors:  Xingcheng Lin; Rachel Leicher; Shixin Liu; Bin Zhang
Journal:  Nucleic Acids Res       Date:  2021-06-21       Impact factor: 16.971

3.  NRF1 association with AUTS2-Polycomb mediates specific gene activation in the brain.

Authors:  Sanxiong Liu; Kimberly A Aldinger; Chi Vicky Cheng; Takae Kiyama; Mitali Dave; Hanna K McNamara; Wukui Zhao; James M Stafford; Nicolas Descostes; Pedro Lee; Stefano G Caraffi; Ivan Ivanovski; Edoardo Errichiello; Christiane Zweier; Orsetta Zuffardi; Michael Schneider; Antigone S Papavasiliou; M Scott Perry; Jennifer Humberson; Megan T Cho; Astrid Weber; Andrew Swale; Tudor C Badea; Chai-An Mao; Livia Garavelli; William B Dobyns; Danny Reinberg
Journal:  Mol Cell       Date:  2021-10-11       Impact factor: 17.970

4.  Determination of Histone Methyltransferase Structures in Complex with the Nucleosome by Cryogenic Electron Microscopy.

Authors:  Cathy J Spangler; Robert K McGinty
Journal:  Methods Mol Biol       Date:  2022

5.  Recurrent chromosomal translocations in sarcomas create a megacomplex that mislocalizes NuA4/TIP60 to Polycomb target loci.

Authors:  Nikita Avvakumov; Marie-Eve Lalonde; Nader Alerasool; Charles Joly-Beauparlant; Karine Jacquet; Amel Mameri; Deepthi Sudarshan; Jean-Philippe Lambert; Justine Rousseau; Catherine Lachance; Eric Paquet; Lara Herrmann; Samarth Thonta Setty; Jeremy Loehr; Marcus Q Bernardini; Marjan Rouzbahman; Anne-Claude Gingras; Benoit Coulombe; Arnaud Droit; Mikko Taipale; Yannick Doyon; Jacques Côté
Journal:  Genes Dev       Date:  2022-06-16       Impact factor: 12.890

6.  The histone H3K9M mutation synergizes with H3K14 ubiquitylation to selectively sequester histone H3K9 methyltransferase Clr4 at heterochromatin.

Authors:  Chun-Min Shan; Jin-Kwang Kim; Jiyong Wang; Kehan Bao; Yadong Sun; Huijie Chen; Jia-Xing Yue; Alessandro Stirpe; Zhiguo Zhang; Chao Lu; Thomas Schalch; Gianni Liti; Peter L Nagy; Liang Tong; Feng Qiao; Songtao Jia
Journal:  Cell Rep       Date:  2021-05-18       Impact factor: 9.423

Review 7.  Principles of nucleosome recognition by chromatin factors and enzymes.

Authors:  Robert K McGinty; Song Tan
Journal:  Curr Opin Struct Biol       Date:  2021-06-28       Impact factor: 6.809

Review 8.  Histone H1 Mutations in Lymphoma: A Link(er) between Chromatin Organization, Developmental Reprogramming, and Cancer.

Authors:  Alexey A Soshnev; C David Allis; Ethel Cesarman; Ari M Melnick
Journal:  Cancer Res       Date:  2021-09-27       Impact factor: 13.312

9.  Distinct PRC2 subunits regulate maintenance and establishment of Polycomb repression during differentiation.

Authors:  Ana Petracovici; Roberto Bonasio
Journal:  Mol Cell       Date:  2021-04-21       Impact factor: 19.328

Review 10.  Not just a writer: PRC2 as a chromatin reader.

Authors:  Michael Uckelmann; Chen Davidovich
Journal:  Biochem Soc Trans       Date:  2021-06-30       Impact factor: 5.407
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.