| Literature DB >> 33475999 |
Stefanie J Hectors1,2,3, Philippe Garteiser4, Sabrina Doblas4, Gwenaël Pagé4, Bernard E Van Beers5, John C Waterton6, Octavia Bane7,8.
Abstract
In renal MRI, measurement of the T1 relaxation time of water molecules may provide a valuable biomarker for a variety of pathological conditions. Due to its sensitivity to the tissue microenvironment, T1 has gained substantial interest for noninvasive imaging of renal pathology, including inflammation and fibrosis. In this chapter, we will discuss the basic concept of T1 mapping and different T1 measurement techniques and we will provide an overview of emerging preclinical applications of T1 for imaging of kidney disease.This chapter is based upon work from the COST Action PARENCHIMA, a community-driven network funded by the European Cooperation in Science and Technology (COST) program of the European Union, which aims to improve the reproducibility and standardization of renal MRI biomarkers. This introduction chapter is complemented by two separate chapters describing the experimental procedure and data analysis.Entities:
Keywords: Kidney; Magnetic resonance imaging (MRI); Parametric imaging; Preclinical; T1 mapping
Year: 2021 PMID： 33475999 DOI： 10.1007/978-1-0716-0978-1_9
Source DB: PubMed Journal: Methods Mol Biol ISSN： 1064-3745